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Valvular Heart Disease
Dr . HANAN ALBACKR
Cardiac Anatomy 101
Cardiac Anatomy 101
Spectrum of VHD
Aortic Valve
Mitral Valve
Tricuspid Valve
Pulmonic Valve
Spectrum of VHD
Regurg
Aortic Valve
Stenosis
Regurg
Mitral Valve
Stenosis
Regurg
Tricuspid Valve
Stenosis
Regurg
Pulmonic Valve
Stenosis
Spectrum of VHD
Regurg Acute
Aortic Valve Chronic
Stenosis Acute
Chronic
Regurg Acute
Mitral Valve Chronic
Stenosis Acute
Chronic
Regurg Acute
Tricuspid Valve Chronic
Stenosis Acute
Chronic
Regurg Acute
Pulmonic Valve Chronic
Stenosis Acute
Chronic
Spectrum of VHD
Regurg Acute
Aortic Valve Chronic
Stenosis Acute
Chronic
Regurg Acute
Mitral Valve Chronic
Stenosis Acute
Chronic
Spectrum of VHD
Regurg Acute
Aortic Valve Chronic
Stenosis
Chronic
Regurg Acute
Mitral Valve Chronic
Stenosis
Chronic
Spectrum of VHD
Regurg Acute
Aortic Valve Chronic
Stenosis
Chronic
Regurg Acute
Mitral Valve Chronic
Stenosis
Chronic
Spectrum of VHD  Right Sided VHD
Tricuspid Valve
Endocarditis
 IV drug abusers or in patients with IVs
Carcinoid HD - classically TS
TR  common, benign, may be secondary to
Pulm HTN
Pulmonic Valve
Pediatrics  Pulm Stenosis
Rheumatic HD  PI (Graham Steel Murmur)
Right sided valvular lesions change in intensity with
inspiration
Lecture 4-Valvular Hikkeart Diseases.ppt
Cardiac Physiology 101
Systole AV/PV  opens
S1-S2 MV/TV  closes
Diastole AV/PV  closes
S2-S1 MV/TV  opens
Cardiac Physiology 101
Regurg/ Insuff  leaking (backflow) of blood across a closed valve
Stenosis  Obstruction of (forward) flow across an opened valve
Systole AV/PV  opens-------Aortic Stenosis
S1-S2 MV/TV  closes------Mitral Regurg
Diastole AV/PV  closes------Aortic Regurg
S2-S1 MV/TV  opens-------Mitral Stenosis
These concepts are set in stone, it cant occur any other way,
It would be anatomically impossible
Lecture 4-Valvular Hikkeart Diseases.ppt
Valvular Heart Disease
Aortic Valve
 Aortic Stenosis
 Aortic Regurgitation
Aortic Stenosis
Etiologies
 Congenital 0-30 yrs
 Bicuspid 30-50 yrs
 Rheumatic 30-60 yrs
 Degenerative >60 yrs
Aortic Stenosis
Aortic Stenosis  pathophysiology
Aortic Stenosis
Physical Exam
 Harsh Systolic Ejection Murmur  late peaking
 S4 gallop (from LVH)
 Sustained Bifid LV impulse (from LVH)
 Pulsus Parvus et Tardus (Carotid Impulse)
Aortic Stenosis
Symptoms
 Angina
 Syncope
 Congestive Heart Failure (CHF)
Aortic Stenosis
Aortic Stenosis
Aortic Stenosis
Diagnosis
 Ecg  LAE, LVH
 Echo 2D/color doppler test of choice
 Cardiac Cath  helpful, confirmatory, needed if
the pt is older  look at the coronaries
Aortic Stenosis
Treatment of Symptomatic Aortic Stenosis or
Decreased LV Function
Medical Therapy  treats the symptoms not the cause
Aortic Valve Replacement
Bioprosthetic vs Mechanical AVR
Valvular Heart Disease
Aortic Valve
 Aortic Stenosis
 Aortic Regurgitation
Aortic Regurgitation
Etiologies
 Abnormalities of the Leaflets
 Rheumatic, Bicuspid, Degenerative
 Endocarditis
 Dilation of the Aortic Annulus
 Aortic Aneurysm / Dissection
 Inflammatory (Syphyllis, Giant Cell Arteritis.
Coll Vasc Dis-Ankylosis Spondylitis, Reiters)
 Inheritable (Marfans, Osteogensis Imperfecta)
Aortic Regurg  pathophysiology
Aortic Regurg  pathophysiology
Aortic Regurgitation
Aortic Regurgitation
Physical Exam
 Diastolic Decrescendo Blowing Murmur
 Hyperdynamic LV apical impulse
 Bounding Pulses
 S4, S3 Gallop-advanced AI
 Apical Rumble  Austin Flint Murmur
Aortic Regurg  Austin Flint Murmur
Due to the vibration of the anterior leaflet of the mitral valve
as it is buffetted simultaneously by the blood jets from the left
atrium and the aorta.
Aortic Regurgitation
Diagnosis
 Ecg  LAE, LVH
 Echo 2D/color doppler test of choice
 Cardiac Cath  helpful, confirmatory, needed if
the pt is older  look at the coronaries
Aortic Regurgitation
Treatment of Asymptomatic Aortic Regurg
Medical Therapy  treats the symptoms not the cause
 Serial Check ups with Echos (eval EF, Severity AR)
 SBE Prophylaxis
 Vasodialators (Nifedipine, ACE-I)
 Diuretics
Treatment of Symptomatic Aortic Regurg
Aortic Valve Replacement
Bioprosthetic vs Mechanical AVR
If you're not confused,
you're not paying
attention.
Tom Peters
Valvular Heart Disease
Mitral Valve
 Mitral Regurgitation
 Mitral Stenosis
Mitral Regurgitation
Etiologies
 Alterations of the Leaflets, Commissures, Annulus
 Rheumatic
 MVP
 Endocarditis
 Alterations of LV or LA size and Function
 Papillary Muscle (Ischemic, MI, Myocarditis, DCM)
 HOCM
 LV Enlargement  Cardiomyopathies -
 LA Enlargement from MR 
 MR begets MR
Mitral Regurgitation
Mitral Regurg  pathophysiology
Mitral Regurgitation
Symptoms
 Fatigue and weakness
 Dyspnea and orthopnea
 Right sided HF
 MVP Syndrome (if present)
Mitral Regurgitation
Physical Exam
 Holosystolic Apical Blowing Murmur
 Laterally displaced apical impulse
 Split S2 (but is obscured by the murmur)
 S3 Gallop (increased volume during diastole)
 Radiation depends on the etiology
Mitral Regurgitation -MVP
Mitral Regurgitation
Diagnosis
 Ecg  LAE, LVH
 Echo 2D/color doppler test of choice
 Cardiac Cath  helpful, confirmatory, needed if
the pt is older  look at the coronaries
Mitral Regurgitation
- SBE Prophylaxis
Mitral Regurgitation -MVP
Mitral Regurgitation -MVP
Diagnosis and Treatment
 Echo 2D/Color
 B-Blockers (hyperadrenergic symptoms, Palpitations)
 Aspirin (TIAs without etiology)
 SBE Prophylaxis (only if associated with MR)
 Severe Symptomatic MR  same as chronic MR
Valvular Heart Disease
Mitral Valve
 Mitral Regurgitation
 Mitral Stenosis
Mitral Stenosis
Etiologies
 Rheumatic  almost all cases in adults
 Mitral Annular Ca+ - massive (rare)
 Congenital  rare
Mitral Stenosis
Mitral Stenosis
Mitral Stenosis
Mitral Stenosis
Physical Exam
 Loud S1
 Opening Snap
 Diastolic Apical Rumble (murmur)
 May be associated with:
 MR or AS
 Right Sided Murmurs
o PI  Graham Steel Murmur
o TR
Mitral Stenosis
Diagnosis
 Ecg  A Fib, LAE, RAE, RVH
 Echo 2D/color doppler test of choice
 Cardiac Cath  helpful, confirmatory, needed if
the pt is older  look at the coronaries
Mitral Stenosis
Treatment of Symptomatic Mitral Stenosis
Medical Therapy  treats the symptoms not the cause
 Diuretics  for congestion
 Digoxin, Beta and Ca Channel Blockers for Afib
rate control
 Anticoagulation  for AFib and LA clots
 SBE Prophylaxix  prevent endocarditis
Mitral Stenosis
Treatment of Symptomatic Mitral Stenosis
Surgical Therapy  treats the cause
 Percutaneous Ballon Valvulaoplasty  Non-
calcified, pliable valve

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Lecture 4-Valvular Hikkeart Diseases.ppt