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Psycho-Oncology Curriculum 2020-22
Bereavement responses and the mourning process
Carl E. Scheidt
Abteilung Psychosomatische Medizin und Psychotherapie
Universitätsklinik Freiburg und
Thure von Uexküll-Klinik Freiburg
UNIVERSITÄTSKLINIKUM
Freiburg
 Increased risk of physical illnesses
pain Bradbeer et al. Clin J Pain 2003
general physical ailments Stroebe, et al. in press
weight loss Shahar et al. J Aging Health 2001
medication, hospitalization Stroebe et al. Lancet 2007
Grief – physical illnesses
UNIVERSITÄTSKLINIKUM
Freiburg
Death rates of widowers in comparison to married
individuals of the same age (Barkes 1969)
1. half-year 2. half-year 2. year 3. year 4. year 5. year 6. year
UNIVERSITÄTSKLINIKUM
Freiburg
UNIVERSITÄTSKLINIKUM
Freiburg
 Increased mortality of widow(er)s
Lichtenstein et al. Psychol Med 1998
 Increased mortality of mothers directly after the death of a
child
Li et al. Lancet 2003
Grief - Mortality
 Increased mortality of not re-married widowed men;
of younger widowed women
Li Soc Sci Med 1995, Schaefer C, Quesenberry et al. 1995
UNIVERSITÄTSKLINIKUM
Freiburg
Risk factors
 Circumstances of death (e.g. unexpected, traumatic)
 Psychosocial stressors
Individual protective factors
 Optimism, self-worth,
 Secure attachment
Unresolved
 Religion
 Quality of relationships (e.g. dependent, ambivalent)
Influencing factors of the mourning process
Stroebe M, et al., Lancet 2007
UNIVERSITÄTSKLINIKUM
Freiburg
Grief – Functional Neuroanatomy
Gündel et al. Am J Psychiatry 2003
N= 8, female, death of a close relative within the last half-year (no control group!)
Paradigm:
image of the deceased relative vs. neutral image of a random person,
15 words related to the deceased relative vs. 15 neutral words
Design:
2 X 2 design with 4 conditions
(image of deceased relative with
personal and neutral words,
neutral image of a stranger with
personal and neutral words.
UNIVERSITÄTSKLINIKUM
Freiburg
8 trauernde Frauen
Grief – Functional Neuroanatomy
Gündel et al. Am J Psychiatry 2003
Images and words: Posterior cingulate cortex, medial frontal gyrus, cerebellum
Image: Cuneus, Insular cortex, dorsales anteriores cingulum
Words: Precuneus/ medial parietal cortex, precentral gyrus, vermis
UNIVERSITÄTSKLINIKUM
Freiburg
Sample groups: 12 women after loss of their child in late pregnancy vs. 12 mothers of
healthy children
conditions: happy face of a baby / happy face of an adult / neutral face of an adult
activated brain areas: amygdala, posterior cingulate cortex, brainstem, visual cortex
Grief – Functional Neuroanatomy
Kersting et al.
UNIVERSITÄTSKLINIKUM
Freiburg
Women after loss of child / mothers of
healthy children
face of a baby / neutral face
ROI-Analysis
Posterior cingular cortex
-1
-0,8
-0,6
-0,4
-0,2
0
0,2
0,4
0,6
0,8
1
baby happy neutral baby happy neutral
left right
Contrastvalue.
women after loss
control group
Grief – Functional Neuroanatomy
Kersting et al. in press
UNIVERSITÄTSKLINIKUM
Freiburg
Thank you for your attention !

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  • 1. Psycho-Oncology Curriculum 2020-22 Bereavement responses and the mourning process Carl E. Scheidt Abteilung Psychosomatische Medizin und Psychotherapie Universitätsklinik Freiburg und Thure von Uexküll-Klinik Freiburg
  • 2. UNIVERSITÄTSKLINIKUM Freiburg  Increased risk of physical illnesses pain Bradbeer et al. Clin J Pain 2003 general physical ailments Stroebe, et al. in press weight loss Shahar et al. J Aging Health 2001 medication, hospitalization Stroebe et al. Lancet 2007 Grief – physical illnesses
  • 3. UNIVERSITÄTSKLINIKUM Freiburg Death rates of widowers in comparison to married individuals of the same age (Barkes 1969) 1. half-year 2. half-year 2. year 3. year 4. year 5. year 6. year
  • 5. UNIVERSITÄTSKLINIKUM Freiburg  Increased mortality of widow(er)s Lichtenstein et al. Psychol Med 1998  Increased mortality of mothers directly after the death of a child Li et al. Lancet 2003 Grief - Mortality  Increased mortality of not re-married widowed men; of younger widowed women Li Soc Sci Med 1995, Schaefer C, Quesenberry et al. 1995
  • 6. UNIVERSITÄTSKLINIKUM Freiburg Risk factors  Circumstances of death (e.g. unexpected, traumatic)  Psychosocial stressors Individual protective factors  Optimism, self-worth,  Secure attachment Unresolved  Religion  Quality of relationships (e.g. dependent, ambivalent) Influencing factors of the mourning process Stroebe M, et al., Lancet 2007
  • 7. UNIVERSITÄTSKLINIKUM Freiburg Grief – Functional Neuroanatomy Gündel et al. Am J Psychiatry 2003 N= 8, female, death of a close relative within the last half-year (no control group!) Paradigm: image of the deceased relative vs. neutral image of a random person, 15 words related to the deceased relative vs. 15 neutral words Design: 2 X 2 design with 4 conditions (image of deceased relative with personal and neutral words, neutral image of a stranger with personal and neutral words.
  • 8. UNIVERSITÄTSKLINIKUM Freiburg 8 trauernde Frauen Grief – Functional Neuroanatomy Gündel et al. Am J Psychiatry 2003 Images and words: Posterior cingulate cortex, medial frontal gyrus, cerebellum Image: Cuneus, Insular cortex, dorsales anteriores cingulum Words: Precuneus/ medial parietal cortex, precentral gyrus, vermis
  • 9. UNIVERSITÄTSKLINIKUM Freiburg Sample groups: 12 women after loss of their child in late pregnancy vs. 12 mothers of healthy children conditions: happy face of a baby / happy face of an adult / neutral face of an adult activated brain areas: amygdala, posterior cingulate cortex, brainstem, visual cortex Grief – Functional Neuroanatomy Kersting et al.
  • 10. UNIVERSITÄTSKLINIKUM Freiburg Women after loss of child / mothers of healthy children face of a baby / neutral face ROI-Analysis Posterior cingular cortex -1 -0,8 -0,6 -0,4 -0,2 0 0,2 0,4 0,6 0,8 1 baby happy neutral baby happy neutral left right Contrastvalue. women after loss control group Grief – Functional Neuroanatomy Kersting et al. in press