Leukemia
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Chronic leukemia results in a neoplastic proliferation of B-cells that causes few complications initially, allowing for a normal hemoglobin and platelet count. Acute leukemia originates in the bone marrow's hematopoietic stem cells, affecting all cell lineages and commonly presenting with anemia and low platelet count due to its more rapid progression overwhelming normal blood cell production. Unlike chronic leukemia, acute leukemia typically impacts red and platelet cell development in the bone marrow from the onset.
Leukemia
- 1. IBMGYEAR 2 TUTOR GROUP 2 MAY 2015 WEEK 4/5 CASE A QUESTION 2 Why do patients with chronic leukemia have a normal Hb and platelet count? Why does acute leukemia often present with abnormal Hb and platelet count? (Also known as anaemia and thrombocytopenia)
- 2. This is how chronic leukemia can be de鍖ned: A neoplastic proliferation of B-cells A possible complication: - auto-immune hemolytic anemia Also: May progress to diffuse B-cell lymphoma
- 3. This is where acute leukemia starts - the hpc in the bone marrow Thus, it has an effect on all the cell lineages! This is why abnormal hb and platelet counts are seen more often in acute leukemia than in chronic leukemia.