Leukocyte adhesion deficiency HY
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Leukocyte adhesion deficiency is caused by a defect in CD18-containing integrins, which impairs leukocyte adhesion and endothelial transmigration. This results in recurrent skin and mucosal infections without pus formation, impaired wound healing, and delayed umbilical cord separation beyond 3 weeks of age. Laboratory findings include leukocytosis and neutrophilia.
Leukocyte adhesion deficiency HY
- 1. Leukocyte adhesion deficiency Pathophysiology ? Defect in CD18-containing integrins ? Impaired leukocyte adhesion & endothelial transmigration Clinical features ? Skin & mucosal infections (eg, cellulitis, periodontitis) without pus formation ? Impaired wound healing ? Delayed umbilical cord separation (age >3 weeks) Laboratory findings ? Leukocytosis & neutrophilia