LIVER FUNCTION TES class .ppt for nursing students
- 4. According to function of liver According to function of liver Classification of LFT Tests based on synthetic function Tests based on synthetic function Tests based on excretory function Tests based on excretory function Tests based on detoxification function Tests based on detoxification function Tests based on metabolic function Tests based on metabolic function Determination of serum enzymes Determination of serum enzymes I II III IV V
- 8. Tests related to CARBOHYDRATE metabolism Tests related to LIPID metabolism Tests related to PROTEIN metabolism Galactose tolerance test Serum cholesterol Serum proteins Aminoaciduria
- 15. • Serum bilirubin estimation is based on van den Berg’s diazo reaction. • Diazo reagent consists of diazotized sulfanic acid Determination of Serum Bilirubin
- 19. Laboratory results S Bilirubin U Urobilinogen U Bilirubin F Urobilinoge Conjugated Unconjugated Normal 0.1-0.4mg/ dl 0.2-0.7mg/dl 0.4mg/day Absent 40-280mg/ day Prehepatic Normal Increased Increased Absent Increased Hepatic Increased Increased N/Decreased Present Decreased Posthepatic Increased Normal Absent Present Trace to absent
- 21. Tests b/o detoxification function
- 22. Liver is the main source of synthesis of Plasma proteins - Albumin - Globulin(except γ) Blood clotting factors - Prothrombin and factors V, VII and X. Tests b/o synthetic function
- 23. Determination of serum albumin and globulin Albumin/globulin ratio = 1.2:1 to2.5:1
- 24. Determination of Prothrombin time
- 25. Tests related to CARBOHYDRATE metabolism Tests related to LIPID metabolism Tests related to PROTEIN metabolism Tests b/o metabolic function Galactose tolerance test Serum cholesterol Serum proteins Aminoaciduria
- 26. • In liver cell injury, damage to the membrane of cells and organelles allows intracellular enzymes to leak into the blood. • Where their elevated concentrations can be measured Enzymes in diagnosis of liver disease
- 28. Serum transaminases AST or SGOT=<35U/L ALT or SGPT=<40U/L S. alkaline phosphatase ALP= 3-13KA units/dl ALP is normally excreted through bile ↑↑↑In obstructive jaundice Enzymes in liver disease
- 29. Enzyme Prehepatic Jaundice Hepatic Jaundice Obstructive Jaundice ALT or AST Usually normal Marked increase 500-1500IU/L Increased 100-300IU/L ALP Normal Increased slightly < 30KA/dl Marked increase >30KA/dl Enzyme assays in differential diagnosis of Jaundice
- 30. Other enzymes
- 31. Thank you