Melanoma1

Oct 29, 2011Download as pptx, pdf

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This document discusses melanoma, including risk factors like sun exposure and tanning beds. It covers the staging of melanoma from Stage 0 to Stage 4 and treatments that may be used like surgery, sentinel node biopsy, interferon, Yervoy, and Zelboraf. Surgical margins and additional testing are also mentioned.

Donna V. Puleio, M. D.
UPMC Cancer Center

MELANOMA

This document summarizes melanoma, a type of skin cancer. It originates from melanocytes in the skin or mucosal surfaces. Melanoma is more common and dangerous in white people and younger women. The main risk factor is ultraviolet radiation from the sun or tanning beds. There are four main types of melanoma named after their appearance or location on the skin. Doctors diagnose melanoma through history, physical exam, and biopsy. It is staged based on how deep it has penetrated the skin and if it has spread. Treatment options range from surgery for early stages to immunotherapy and chemotherapy for later stages.

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Melanoma is the most lethal form of skin cancer. While it only accounts for about 3% of skin cancer cases, it causes around 75% of skin cancer deaths. The rate of melanoma is increasing in older age groups. Risk factors include poor tanning ability, red or blond hair, family history, and sun exposure. Melanoma can spread locally, to lymph nodes, or distantly to organs. Staging involves tumor thickness and presence of metastases. Treatment involves surgery to remove the primary tumor and lymph nodes, with the addition of radiation therapy or immunotherapy for higher-risk cases. Advanced or metastatic melanoma may be treated with targeted therapies, immunotherapy, chemotherapy, or palliative radiation.

Melanoma ForooghAustralia

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Malignant melanoma is a skin cancer from uncontrolled growth of melanocytes, primarily caused by genetic factors and UV exposure, with increasing worldwide incidence. Diagnosis involves clinical evaluation, pathology, and imaging to determine staging, with treatment options including surgery, chemotherapy, and radiotherapy. Early detection is crucial for a favorable prognosis, with survival rates varying significantly based on tumor thickness and other factors.

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Melanoma presentationmarsha11

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Melanoma is the sixth most common cancer in the US, with 68,000 new cases diagnosed each year and 8,700 annual deaths. Risk factors include fair skin, light eyes, family history, and sun exposure. Melanoma has been recognized as a disease since 1806 and stages range from Stage 0 precancerous lesions to Stage IV metastatic cancer. Treatment options depend on the stage and may include surgery, radiation, immunotherapy, and experimental therapies.

Skin CancerMuhammad Eimaduddin

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The document provides an overview of skin cancer types, including melanoma, basal cell carcinoma, and squamous cell carcinoma, detailing their characteristics, risk factors, and treatment options. Melanoma is highlighted as the most serious form of skin cancer, while basal and squamous cancers are the most common, often linked to sun exposure. Treatment methods range from excision and cryotherapy to topical creams, with specific approaches for different cancer types and stages.

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The document discusses melanoma, covering its definition, prevalence, risk factors, prevention, detection, diagnosis, and treatment options. It highlights the rising mortality rates despite advances in detection and emphasizes the importance of public awareness and professional screening. Treatment options are detailed, including surgical and medical interventions, with a focus on the roles of dermatologists and oncologists in managing melanoma cases.

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This document provides an overview of melanoma, including its causes, risk factors, types, diagnosis, staging, and treatment. It discusses that melanoma arises from melanocytes, can spread from the skin to other organs, and accounts for the majority of skin cancer deaths. Early detection through changes in moles is important for improved prognosis, as thickness and spread determine survival rates. Surgical removal is the main treatment, and sentinel lymph node biopsy helps determine if it has spread to lymph nodes.

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This document summarizes diagnosis and management of various skin cancers and pigmented lesions. It discusses diagnosis and treatment options for basal cell carcinoma, squamous cell carcinoma, melanoma, and other skin tumors. Photodynamic therapy is described as an 80% effective treatment for superficial basal cell carcinoma. Metastatic rates for squamous cell carcinoma are provided based on literature reviews. Risk factors and treatment guidelines are outlined for melanoma depending on depth of invasion and presence of metastases. Differential diagnoses are also reviewed for problematic pigmented lesions and melanomas.

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Malignant melanoma begins in melanocytes in the epidermis and is becoming more common, rising 3% per year. It accounts for about 2-4% of skin cancers. Risk factors include sun exposure and fair skin. Early stage melanoma is treated with wide local excision, while more advanced cases may also require sentinel node biopsy. Treatment of metastatic melanoma has advanced significantly with targeted therapies blocking oncogenic pathways like BRAF and immunotherapies disrupting checkpoints like CTLA-4. Long term survival depends on factors like depth of invasion and ulceration.

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This document provides information on malignant melanoma. Some key points: - Melanoma is a malignancy of melanocytes that can occur in skin, eyes, and mucous membranes. It has a high ability to metastasize to other organs. - Incidence is increasing worldwide. Risk factors include fair skin, moles, UV exposure, and family history. - Diagnosis involves examining lesions for characteristics like asymmetry, irregular borders, varied color, and size over 6mm. Biopsies are used to confirm. - Staging uses the TNM system and considers tumor thickness, ulceration, and lymph node/distant organ involvement. Prognosis depends on stage - thicker tumors over 2mm

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This document discusses skin cancer, specifically melanoma. It notes that melanoma accounts for 1-5% of skin cancers but causes the majority of skin cancer deaths. Risk factors include family history, sun exposure, skin sensitivity, and immunosuppression. The main types of melanoma are superficial spreading, nodular, lentigo maligna, and acral lentiginous. Diagnosis involves examining lesions for characteristics like asymmetry, irregular border, multiple colors, diameter over 6mm, and changes over time. Treatment depends on cancer stage and may include surgery, radiation, immunotherapy, targeted therapy, chemotherapy, or a combination.

4part1dthewitt

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This document discusses skin cancer diagnosis and management. It provides statistics showing that skin cancer is the most commonly diagnosed cancer in Australia, with over 80% of cases being non-melanoma skin cancer. The two main types of non-melanoma skin cancer are basal cell carcinoma and squamous cell carcinoma. The document discusses the clinical presentation, differential diagnosis, and treatment options for actinic keratosis, basal cell carcinoma, and squamous cell carcinoma. Cryotherapy, curettage and cautery, topical chemotherapy agents like imiquimod, photodynamic therapy, and surgical excision are among the treatment approaches covered.

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The document discusses skin cancer, including its definition and types such as basal cell carcinoma, squamous cell carcinoma, and melanoma, which has a very low survival rate. It introduces the ABCDE rule for detecting melanoma and outlines treatment options including surgery, radiotherapy, and chemotherapy. The document also provides preventive measures for self-examination to identify potential skin cancer early.

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Malignant melanoma incidence has been increasing 6% per year, making it one of the fastest growing cancers. Early diagnosis through thorough examination and surgical removal of the tumor are the most important treatment methods. Survival rates have increased from 50% in 1960 to 80% in 1990 due to earlier detection and treatment. Risk factors include fair skin, sun exposure, and genetic conditions.

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MelanomaOther Mother

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This document provides information about melanoma, a serious type of skin cancer. It defines melanoma as cancer of the melanocytes, which are cells that produce skin pigment. Risk factors include family history, many moles, sunburn, and fair skin. Signs include changes in existing moles or new abnormal growths. The stages are described from earliest (stage 0) to latest (stage IV), with treatment options at each stage. Prevention focuses on sun protection and avoiding sun exposure when UV rays are strongest.

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The document discusses melanoma, a preventable and aggressive skin cancer with increasing incidence rates, particularly among men over 50 and ethnic minorities. It emphasizes prevention through sun safety behaviors, the importance of early detection and screening, and outlines the various types of melanoma and their characteristics. Adherence to sun protection measures and regular skin examinations are stated as crucial for reducing melanoma risk and improving survival rates.

Head and neck melanomablack lion hospital

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This document outlines the management of head and neck melanoma. It discusses the epidemiology, classification, evaluation, diagnosis and prognostic factors of melanoma. It emphasizes that surgical excision is the standard treatment for primary melanoma and margins depend on tumor thickness. Staging relies on the AJCC system and considers factors like thickness, ulceration, mitosis and lymph node involvement to determine prognosis.

Melanoma and melanoma types with treatmentKamal Uddin Rayhan

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1. Melanoma is a malignant tumor of melanocytes that can arise in the skin or other parts of the body. 2. Risk factors for melanoma include excessive exposure to UV radiation, fair skin, and family history. 3. There are several types of melanoma including superficial spreading, nodular, lentigo maligna, and acral lentiginous melanoma. 4. Prevention strategies include avoiding sun exposure, wearing protective clothing, and eating a diet high in antioxidants. Medical treatment options include immunotherapy, chemotherapy, radiation therapy, targeted therapy and biologic therapy.

MelanomaShyala Chand

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Melanoma is a malignant skin cancer that develops from pigment-producing cells called melanocytes. It accounts for only 1% of skin cancers but causes the majority of skin cancer deaths. Risk factors include sun exposure, the use of tanning beds, and family history. Genetic mutations in genes like BRAF, NRAS, and CDKN2A contribute to melanoma development and progression. Different types of melanoma exist including superficial spreading, nodular, lentigo maligna, acral lentiginous, and ocular/mucosal melanoma. Staging uses the Clark level and Breslow thickness scales. Treatment depends on stage but may include surgery, immunotherapy, targeted therapy, and chemotherapy. Prevention involves sun protection

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The document discusses various controversies surrounding melanoma, focusing on its epidemiology, etiopathogenesis, and diagnostic methods. It highlights debates on the existence of a true melanoma epidemic, the nuanced relationship between sun exposure and melanoma risk, and the fluctuating role of hormones in melanoma incidence and prognosis. Additionally, it examines the significance of sentinel lymph node biopsy in melanoma staging, noting the complexities in its interpretation and clinical application.

Melanoma sign symptom management surgery prevention ملانوم سید محسن ساداتی نژاد sadatinejad

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Melanoma is a type of skin cancer that originates from melanocytes and is responsible for most skin cancer-related deaths, with key risk factors including family history, fair skin, and excessive sun exposure. Early detection and treatment, often via surgery, can lead to a high cure rate, but late-stage melanoma can spread to other organs, requiring more extensive treatments. Preventative measures such as using sunscreen and protecting the skin from UV rays are critical to reducing the risk of developing melanoma.

Melanoma Case StudyKate Marielle Balueta

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Melanoma is a type of skin cancer that develops from melanocytes, which are the cells that produce melanin and give skin its color. It is the deadliest form of skin cancer and is no longer considered only an "old person's disease" as cases are increasing in younger people due to childhood sun exposure. The document discusses causes like UV radiation from the sun or tanning beds, risk factors like fair skin and sunburns, signs like an evolving mole, and prevention through sun protection and skin self-exams. Judy, a fair-skinned young woman concerned about a changing mole, may be at risk of melanoma due to her skin type and sun exposure habits. Early detection through screening is important for treatment

Melanoma updateahmed mjali

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The document discusses recommendations from ASCO for sentinel lymph node biopsy and management of regional lymph nodes in melanoma patients. It recommends that SLN biopsy is not needed for thin melanomas less than 0.8mm thick without ulceration. SLN biopsy may be considered for lesions between 0.8-1mm thick or less than 0.8mm thick with ulceration after discussing risks and benefits with the patient. SLN biopsy is also recommended for thick melanomas over 4mm thick after discussing risks and benefits. If the SLN biopsy is positive, completing lymph node dissection is an option.

Squamous cell carcinoma of skin | management -all medical aspects.martinshaji

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Squamous cell carcinoma (SCC) of the skin is a common skin cancer that develops from squamous cells, characterized by thick, scaly lesions that may not heal and can be life-threatening if metastasized. It primarily affects sun-exposed areas and involves high-risk factors such as prior skin damage, and typically requires biopsy for diagnosis and has a good prognosis when treated early. Prevention includes protective clothing and sunscreen, while treatment options range from surgical removal to radiation and chemotherapy, depending on the stage of cancer.

MelanomaVinayak Lokare

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Melanoma is the 5th and 6th most common malignancy in men and women respectively. It accounts for a disproportionate number of skin cancer deaths. Risk factors include family history, fair skin, intermittent sun exposure, and dysplastic nevi. Melanomas arise from melanocytes and can present in different clinical subtypes depending on their location and growth pattern. Prognosis depends on tumor thickness, ulceration status, mitotic rate, and presence of metastases. Treatment involves surgical excision with margins and possible lymph node evaluation and adjuvant therapy for advanced cases. Lifelong surveillance is important due to the risk of recurrence even decades later.

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