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microemulsions.pptx

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Sunaina Aggarwal
Sunaina Aggarwal

Microemulsions are transparent dispersions of water and oil droplets stabilized by surfactants and co-surfactants. They have particle sizes between 20-200 nm. Microemulsions can solubilize both water-soluble and oil-soluble drugs, increasing their bioavailability. They are thermodynamically stable and have applications in pharmaceuticals, cosmetics, and other industries due to their small particle size and high solubilization capacity. However, high amounts of surfactants required for formation can cause irritation. Factors like temperature and pH also influence stability. Microemulsions have been used to improve the bioavailability of drugs like cyclosporine A and fenofibrate.

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By. Sunaina Aggarwal RKSD College of Pharmacy, Kaithal, Haryana
Microemulsion Microemulsions are mono-dispersed spherical droplets (diameter 20-200 nm) of water in oil or oil in water, with presence of surfactants and co- surfactants which helps in reducing the interfacial tension and hence, stabilizes the system.
Composition of microemulsion Microemulsion is defined as transparent dispersion consisting of (1) Oil. (2) Surfactant. (3) Cosurfactant. (4) water. .
Advantages Thermodynamically stable systems with very small particle size Ultimately increase the surface area of drugs which improves their solubilization and permeation behavior Plasma concentration profiles and drug availability have been more reproducible Drug penetration rate is much faster Higher solubilization capacity Can be manufactured with very little energy input and have a long shelf life Translucent to transparent appearance
 Formation of microemulsions generally requires large amounts of surfactants and co-surfactants. All of these at high concentration are irritating, if not slightly toxic to the biological systems.  Factors such as temperature, pH influences the stability of microemulsions Disadvantages
Uses of Micro Emulsion Nano Science Pharmacy Depurative Make up More and more applications in our life……
formulation of Cyclosporin A microemulsion has increased the bioavailability of the drug. Self emulsifying formulations of fenofibrate or fenofibrate derivatives having an improved oral bioavailability. The self-emulsifying compositions for the improved solubility and bioavailability of CETP Inhibitor. Methasone and pilocarpine microemulsions show better tolerability and higher bioavailability. Microemulsion gel-based system of babchi oil (Psoralea corylifolia) provide improved permeation of the drug through the skin and increased patient compliance. Mylotarg for injection (microemulsion of IgG monoclonal antibodies) given by iv route is another recent advancement. Pharmaceutical Applications
 Cleaners, hair products, perfumes, gels, and skin care products.  Useful media for chemical reactions.  Serve as artificial blood substitutes.  In preparation of nanoparticles.  Enhanced Oil Recovery using Microemulsions. Microemulsions in Daily Life
Microemulsions as vehicle  Has a unique solubilization properties.  Improves bioavailability of drugs.  Provides better absorption in body.  Have attracted increasing attention as potential drug delivery systems.  Referred to as novel as still require much attention for research…..
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microemulsions.pptx

  • 1. By. Sunaina Aggarwal RKSD College of Pharmacy, Kaithal, Haryana
  • 2. Microemulsion Microemulsions are mono-dispersed spherical droplets (diameter 20-200 nm) of water in oil or oil in water, with presence of surfactants and co- surfactants which helps in reducing the interfacial tension and hence, stabilizes the system.
  • 3. Composition of microemulsion Microemulsion is defined as transparent dispersion consisting of (1) Oil. (2) Surfactant. (3) Cosurfactant. (4) water. .
  • 4. Advantages Thermodynamically stable systems with very small particle size Ultimately increase the surface area of drugs which improves their solubilization and permeation behavior Plasma concentration profiles and drug availability have been more reproducible Drug penetration rate is much faster Higher solubilization capacity Can be manufactured with very little energy input and have a long shelf life Translucent to transparent appearance
  • 5.  Formation of microemulsions generally requires large amounts of surfactants and co-surfactants. All of these at high concentration are irritating, if not slightly toxic to the biological systems.  Factors such as temperature, pH influences the stability of microemulsions Disadvantages
  • 6. Uses of Micro Emulsion Nano Science Pharmacy Depurative Make up More and more applications in our life……
  • 7. formulation of Cyclosporin A microemulsion has increased the bioavailability of the drug. Self emulsifying formulations of fenofibrate or fenofibrate derivatives having an improved oral bioavailability. The self-emulsifying compositions for the improved solubility and bioavailability of CETP Inhibitor. Methasone and pilocarpine microemulsions show better tolerability and higher bioavailability. Microemulsion gel-based system of babchi oil (Psoralea corylifolia) provide improved permeation of the drug through the skin and increased patient compliance. Mylotarg for injection (microemulsion of IgG monoclonal antibodies) given by iv route is another recent advancement. Pharmaceutical Applications
  • 8.  Cleaners, hair products, perfumes, gels, and skin care products.  Useful media for chemical reactions.  Serve as artificial blood substitutes.  In preparation of nanoparticles.  Enhanced Oil Recovery using Microemulsions. Microemulsions in Daily Life
  • 9. Microemulsions as vehicle  Has a unique solubilization properties.  Improves bioavailability of drugs.  Provides better absorption in body.  Have attracted increasing attention as potential drug delivery systems.  Referred to as novel as still require much attention for research…..