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Modified Release Drug Products: Delayed Release, Extended release and orally disinfectanting Tablets

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Mukesh Kapse

Biopharmaceutics and Research Methodology. M pharm 1st year 2nd Semester

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MODIFIED RELEASE DRUG PRODUCT NAME MUKESH V KAPSE CLASS M PHARM 1th YEAR 2th SEM ROLL NO 06 SUBJECT Advanced Biopharmaceutics and Pharmacokinetics
CONTENTS Introduction Advantages Types of Modified release drug products Examples of modified release dosage forms Types of Extended Release Products References
INTRODUCTION Modified release drug product are those that alter the timing and/or the rate of release of drug substance.
ADVANTAGES Reduction in drug blood level fluctuation Frequency reduction in dosing Patient compliance Reduced adverse side effect Reduction in health care cost
TYPES OF MODIFIED RELEASE DRUG PRODUCTS 1. Delayed release 2. Extended release 3. Orally disintegrating tablet
DELAYED RELEASE DRUG PRODUCTS Releases a discrete portion of drug at a time other than promptly after administration.e.g - enterric coated dosage forms like enterric coated aspirin,other NSAIDS, etc.
EXTENDED RELEASE DRUG PRODUCTS Two fold release indosage frequency,examples include controlled release, sustained release and long acting drug products.
ORALLY DISINTEGRATING TABLETS Disintegrate rapidly in saliva after oral administration. Can be used without addition of water. Drug dispersed in saliva and swallowed.
EXAMPLES OF MODIFIED RELEASE DOSAGE FORMS
TYPES OF EXTENDED RELEASE PRODUCTS Coated beads, granules, or microspheres Multitablet system Microencapsulated drug Embedding drug in slowly eroding or hydrophilic matrix system Embedding drug in inert plastic matrix Complex formation lon-exchange resins
REFERENCE Shargel leon, WU Pong Susanna, B.C. YU Andrew, Applied Biopharmaceutics and Pharmacokinetics, 5属 edition,rights by McGraw- hill, page no.-516-551
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Modified Release Drug Products: Delayed Release, Extended release and orally disinfectanting Tablets

  • 1. MODIFIED RELEASE DRUG PRODUCT NAME MUKESH V KAPSE CLASS M PHARM 1th YEAR 2th SEM ROLL NO 06 SUBJECT Advanced Biopharmaceutics and Pharmacokinetics
  • 2. CONTENTS Introduction Advantages Types of Modified release drug products Examples of modified release dosage forms Types of Extended Release Products References
  • 3. INTRODUCTION Modified release drug product are those that alter the timing and/or the rate of release of drug substance.
  • 4. ADVANTAGES Reduction in drug blood level fluctuation Frequency reduction in dosing Patient compliance Reduced adverse side effect Reduction in health care cost
  • 5. TYPES OF MODIFIED RELEASE DRUG PRODUCTS 1. Delayed release 2. Extended release 3. Orally disintegrating tablet
  • 6. DELAYED RELEASE DRUG PRODUCTS Releases a discrete portion of drug at a time other than promptly after administration.e.g - enterric coated dosage forms like enterric coated aspirin,other NSAIDS, etc.
  • 7. EXTENDED RELEASE DRUG PRODUCTS Two fold release indosage frequency,examples include controlled release, sustained release and long acting drug products.
  • 8. ORALLY DISINTEGRATING TABLETS Disintegrate rapidly in saliva after oral administration. Can be used without addition of water. Drug dispersed in saliva and swallowed.
  • 9. EXAMPLES OF MODIFIED RELEASE DOSAGE FORMS
  • 10. TYPES OF EXTENDED RELEASE PRODUCTS Coated beads, granules, or microspheres Multitablet system Microencapsulated drug Embedding drug in slowly eroding or hydrophilic matrix system Embedding drug in inert plastic matrix Complex formation lon-exchange resins
  • 11. REFERENCE Shargel leon, WU Pong Susanna, B.C. YU Andrew, Applied Biopharmaceutics and Pharmacokinetics, 5属 edition,rights by McGraw- hill, page no.-516-551