Molecular aerobiology and genomics have emerged as interdisciplinary fields that investigate the airborne distribution and dynamics of biological particles like bacteria, viruses, fungi, and pollen in Earth's atmosphere. Recent advances in high-throughput sequencing and metagenomic analysis have revolutionized the ability to characterize the diversity and abundance of airborne microorganisms and their relation to structural and functional genomics. Genomic techniques now allow researchers to decode the genomic content of aerosols, revealing information about microbial communities, their functions, and interactions with the environment. However, challenges remain regarding standardizing sampling protocols, bioinformatic analyses, and data interpretation across studies, as well as addressing ethical issues related to using genomic data in public