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Antibiotics Protocols in
orthopedics
Dr Razi Ullah
Resident orthopedics Surgeon ATH
 Infection in orthopedic surgery is one of the most
dreaded complications.
 It is associated with prolonged morbidity, disability
and increased mortality.
 Out of nearly 30 million operations in the United
States each year more than 2% are complicated with
surgical site infections.
 The mortality rate increases 23 times after
infection.
 Antibiotics are the cornerstone of prevention
and management of orthopedics infection.
 We will discuss protocols of antibiotics in
 1. Open fractures
 2.Surgical prophylaxis
 3. Bone infection
 Protocol of Antibiotics in open fractures
 Gustilo type 1 and 2
 First generation cephalosporin for 24 hours
 Type 3A
 First generation cephalosporin plus a
aminoglycoside since 72 hours since last incision
and drainage
 Type 3B highly contaminated farm injuries
 First generation cephalosporin plus aminoglycoside
plus high dose penicillin 72 hours since last
incision and drainage
 Freshwater wounds
 Flouroquinolones or third or fourth generation
cephalosporin
 Saltwater wounds
 Doxycycline and fourth generation
cephalosporin or flouroqunolones
 Protocol for Surgical prophylaxis
 There is enough evidence to say that prophylactic
antibiotics should be used in orthopedics to reduce
surgical site infection
 We will discuss timing,choice and duration of
antibiotics for prophylaxis in surgical patients
 Timing of administration
 The timing of administration remains controversial.
 Evidence shows that initiating prophylaxis after the
skin is incised, is ineffective.
 Most of the studies agree that prophylactic
antibiotics should ideally be administered 3060 min
before skin incision
 Administration >60 min before surgery/incision is
associated with higher risk of surgical infections
 The prophylaxis has least effect when
antibiotic is given after the application of a
tourniquet
 Which antibiotics?
The antibiotic selected should in general, be
inexpensive, nontoxic and of limited spectrum.
The most prevalent organisms in prosthetic related
infections are Gram-positive Staphylococcus
aureus and epidermidis
 According to American Society of Health
System Pharmacists (ASHP) cefazolin was the
most used antibiotic in preoperative
prophylaxis, combination of cefazolin with
gentamicin was the second common regimen
while 3rd generation cephalosporin were
3rd widely used antibiotics.
 In a study, 3rd generation cephalosporins were most
commonly used for arthroplasty prophylaxis and
2nd generation cepholospirins were used for fracture
fixation.
 Duration of antibiotics
 The controversy persists in administration of
antibiotics varying from a single dose to 3 doses to 5
days or 14 days
 The ideal duration of postoperative antibiotics is not
yet clearly defined although most reports say that
there is no additional benefit when prophylactic
antibiotics are given more than 24 h postsurgery
 Musmar et al. suggests that antibiotics should be
discontinued within 24 h after end of surgery to
prevent emergence of resistance
 Thonse et al. recommended prophylactic antibiotic
regimen at time of induction of anesthesia and two
subsequent doses at 8 and 16 h postoperatively.
 Another study by Andersson et al. suggest same
recommendations of 3 doses within 24 h.
 Niimi et al. in a retrospective study compared the outcome of
1-day intravenous administration with that of long term
intravenous administration in arthroplasty cases. They used
antibiotics for 1-day (n = 233) and for at least 3 days (n = 104)
 None of these patients developed wound infection during
follow up (minimum 12 months).
 They concluded that 1-day antibiotic infusion was as effective
as long term antibiotic infusion preventing infection after
arthroplasty.
 Protocol of antibiotics in osteomyelitis
 Empirical antibiotics
 Coverage for the most likely infecting organism
should be started till gram stain results appear or if
negative.
 Recommendations for the initiation of empiric
antibiotic (according to age of the patient and
mechanism of infection
 Hematogenous osteomyelitis ( newborn to adult
combination of penicillinase-resistant synthetic
penicillin (Oxacillin or nafcillin) +third-generation
cephalosporin.
 MRSA
 vancomycin or clindamycin +third-generation
cephalosporin, Linezolid is also used in these
circumstances.
 Sickle cell disease:S aureus and Salmonellae species--
----fluoroquinolone antibiotic (not in children).
 A third-generation cephalosporin (eg, ceftriaxone) is
an alternative choice
 In diabetic foot----S aureus and Pseudomonas
aeruginosa----ceftazidime or cefepime. Ciprofloxacin
is an alternative treatment.
 Prosthesis infections S epidermidis----biofilm----
protect bacteria against phagocytosisd antibiotics.
Rifampicin: Must be used in combination with other
antibiotics because it acts on the biofilm and avoids
recurrence if used within a month of treatment
Start IV: The response to appropriate IV antibiotic
usually occur in 48 hr
Lack of improvement in fever and pain after this -----
surgical drainage.
Then use IV (according to culture) for 2 weeks
Oral (combination) for 4 weeks --(revascularization of
bone takes 4 weeks
 Duration of antibiotic therapy
 Most infections- eg S. aureus, a total of 6 wk.
 For group A streptococcus, S. pneumoniae, or
H. influenzae type b---, shorter.
 Immunocompromised patients, mycobacterial
or fungal infection ---- prolonged courses of
therapy.
Monteggia fracture in
children
 Radial head dislocation plus proximal ulna
fracture or
 Plastic deformation of the ulna without
obvious fracture
 Peak age is 4-10 years in children
Monteggia fracture in children
 Bado Classification
 Type I ulna fracture with anterior
dislocation of the radial head
 Type II proximal ulna fracture with posterior
dislocation of the radial head
 Type III proximal ulna fracture with lateral
dislocation of the radial head
 Type IV Fractures of both the radius and
ulna at the same level with an anterior
dislocation of the radial head (1-11% of cases)
 Monteggia equivalents
 isolated radial head dislocation with plastic
deformity of ulna
 fracture of the proximal ulna with fracture of
the radial neck, and
 Both bone proximal third fractures with the
radial fracture more proximal than the ulnar
fracture
 Imaging
 Obtain standard AP and lateral views
 Assess radiocapitellar line on every lateral
radiograph of the elbow
 A line down the radial shaft should pass
through the center of the capitellar
ossification center in all elbow positions
Monteggia fracture in children
Monteggia fracture in children
 Treatment
closed reduction of ulna and radial head
dislocation and long arm casting
Indicated for BADO I-III when
1.Radial head is stable following
reductions
2. Length stable ulnar fracture pattern
 Radial head will reduce spontaneously with
reduction of the ulna and restoration of ulnar length
 Patients should be immobilized in a long arm cast in
90 to 100 degrees of flexion and supination and
followed closely radiographically for 2 to 3 weeks to
ensure maintenance of radial head reduction.
 Operative
 Plating of ulna + reduction of radial head 賊 annular
ligament repair/reconstruction
 Indication
 Bado Types I-III with
radial head is not stable following reduction
ulnar length is not stable (unable to maintain ulnar length)
 acute Bado Type IV
 open fractures
 older patients  10y if closed reduction is not stable
 Technique
 Annular ligament reconstruction almost never
required for acute fractures
 open reduction of radial head through a lateral
approach if needed in chronic (>2-3 weeks old)
Monteggia fractures where radial head still retains
concave structure
 Chronic Monteggia requires ulnar osteotomy with
annular ligament reconstruction via triceps tendon
harvesting
Monteggia fracture in children
 Complications
 posterior interosseous nerve neuropraxia (10% of
acute injuries)almost always spontaneously resolves
 Delayed or missed diagnosis is common when
evaluation not performed by an orthopaedic surgeon
 complication rates and severity increase if diagnosis
delayed >2-3 weeks
Thank You

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Monteggia fracture in children

  • 1. Antibiotics Protocols in orthopedics Dr Razi Ullah Resident orthopedics Surgeon ATH
  • 2. Infection in orthopedic surgery is one of the most dreaded complications. It is associated with prolonged morbidity, disability and increased mortality. Out of nearly 30 million operations in the United States each year more than 2% are complicated with surgical site infections. The mortality rate increases 23 times after infection.
  • 3. Antibiotics are the cornerstone of prevention and management of orthopedics infection. We will discuss protocols of antibiotics in 1. Open fractures 2.Surgical prophylaxis 3. Bone infection
  • 4. Protocol of Antibiotics in open fractures Gustilo type 1 and 2 First generation cephalosporin for 24 hours Type 3A First generation cephalosporin plus a aminoglycoside since 72 hours since last incision and drainage Type 3B highly contaminated farm injuries First generation cephalosporin plus aminoglycoside plus high dose penicillin 72 hours since last incision and drainage
  • 5. Freshwater wounds Flouroquinolones or third or fourth generation cephalosporin Saltwater wounds Doxycycline and fourth generation cephalosporin or flouroqunolones
  • 6. Protocol for Surgical prophylaxis There is enough evidence to say that prophylactic antibiotics should be used in orthopedics to reduce surgical site infection We will discuss timing,choice and duration of antibiotics for prophylaxis in surgical patients
  • 7. Timing of administration The timing of administration remains controversial. Evidence shows that initiating prophylaxis after the skin is incised, is ineffective. Most of the studies agree that prophylactic antibiotics should ideally be administered 3060 min before skin incision Administration >60 min before surgery/incision is associated with higher risk of surgical infections
  • 8. The prophylaxis has least effect when antibiotic is given after the application of a tourniquet
  • 9. Which antibiotics? The antibiotic selected should in general, be inexpensive, nontoxic and of limited spectrum. The most prevalent organisms in prosthetic related infections are Gram-positive Staphylococcus aureus and epidermidis
  • 10. According to American Society of Health System Pharmacists (ASHP) cefazolin was the most used antibiotic in preoperative prophylaxis, combination of cefazolin with gentamicin was the second common regimen while 3rd generation cephalosporin were 3rd widely used antibiotics.
  • 11. In a study, 3rd generation cephalosporins were most commonly used for arthroplasty prophylaxis and 2nd generation cepholospirins were used for fracture fixation.
  • 12. Duration of antibiotics The controversy persists in administration of antibiotics varying from a single dose to 3 doses to 5 days or 14 days The ideal duration of postoperative antibiotics is not yet clearly defined although most reports say that there is no additional benefit when prophylactic antibiotics are given more than 24 h postsurgery
  • 13. Musmar et al. suggests that antibiotics should be discontinued within 24 h after end of surgery to prevent emergence of resistance Thonse et al. recommended prophylactic antibiotic regimen at time of induction of anesthesia and two subsequent doses at 8 and 16 h postoperatively. Another study by Andersson et al. suggest same recommendations of 3 doses within 24 h.
  • 14. Niimi et al. in a retrospective study compared the outcome of 1-day intravenous administration with that of long term intravenous administration in arthroplasty cases. They used antibiotics for 1-day (n = 233) and for at least 3 days (n = 104) None of these patients developed wound infection during follow up (minimum 12 months). They concluded that 1-day antibiotic infusion was as effective as long term antibiotic infusion preventing infection after arthroplasty.
  • 15. Protocol of antibiotics in osteomyelitis Empirical antibiotics Coverage for the most likely infecting organism should be started till gram stain results appear or if negative. Recommendations for the initiation of empiric antibiotic (according to age of the patient and mechanism of infection
  • 16. Hematogenous osteomyelitis ( newborn to adult combination of penicillinase-resistant synthetic penicillin (Oxacillin or nafcillin) +third-generation cephalosporin. MRSA vancomycin or clindamycin +third-generation cephalosporin, Linezolid is also used in these circumstances.
  • 17. Sickle cell disease:S aureus and Salmonellae species-- ----fluoroquinolone antibiotic (not in children). A third-generation cephalosporin (eg, ceftriaxone) is an alternative choice In diabetic foot----S aureus and Pseudomonas aeruginosa----ceftazidime or cefepime. Ciprofloxacin is an alternative treatment.
  • 18. Prosthesis infections S epidermidis----biofilm---- protect bacteria against phagocytosisd antibiotics. Rifampicin: Must be used in combination with other antibiotics because it acts on the biofilm and avoids recurrence if used within a month of treatment
  • 19. Start IV: The response to appropriate IV antibiotic usually occur in 48 hr Lack of improvement in fever and pain after this ----- surgical drainage. Then use IV (according to culture) for 2 weeks Oral (combination) for 4 weeks --(revascularization of bone takes 4 weeks
  • 20. Duration of antibiotic therapy Most infections- eg S. aureus, a total of 6 wk. For group A streptococcus, S. pneumoniae, or H. influenzae type b---, shorter. Immunocompromised patients, mycobacterial or fungal infection ---- prolonged courses of therapy.
  • 22. Radial head dislocation plus proximal ulna fracture or Plastic deformation of the ulna without obvious fracture Peak age is 4-10 years in children
  • 24. Bado Classification Type I ulna fracture with anterior dislocation of the radial head
  • 25. Type II proximal ulna fracture with posterior dislocation of the radial head
  • 26. Type III proximal ulna fracture with lateral dislocation of the radial head
  • 27. Type IV Fractures of both the radius and ulna at the same level with an anterior dislocation of the radial head (1-11% of cases)
  • 28. Monteggia equivalents isolated radial head dislocation with plastic deformity of ulna fracture of the proximal ulna with fracture of the radial neck, and Both bone proximal third fractures with the radial fracture more proximal than the ulnar fracture
  • 29. Imaging Obtain standard AP and lateral views Assess radiocapitellar line on every lateral radiograph of the elbow A line down the radial shaft should pass through the center of the capitellar ossification center in all elbow positions
  • 32. Treatment closed reduction of ulna and radial head dislocation and long arm casting Indicated for BADO I-III when 1.Radial head is stable following reductions 2. Length stable ulnar fracture pattern
  • 33. Radial head will reduce spontaneously with reduction of the ulna and restoration of ulnar length Patients should be immobilized in a long arm cast in 90 to 100 degrees of flexion and supination and followed closely radiographically for 2 to 3 weeks to ensure maintenance of radial head reduction.
  • 34. Operative Plating of ulna + reduction of radial head 賊 annular ligament repair/reconstruction Indication Bado Types I-III with radial head is not stable following reduction ulnar length is not stable (unable to maintain ulnar length) acute Bado Type IV open fractures older patients 10y if closed reduction is not stable
  • 35. Technique Annular ligament reconstruction almost never required for acute fractures open reduction of radial head through a lateral approach if needed in chronic (>2-3 weeks old) Monteggia fractures where radial head still retains concave structure Chronic Monteggia requires ulnar osteotomy with annular ligament reconstruction via triceps tendon harvesting
  • 37. Complications posterior interosseous nerve neuropraxia (10% of acute injuries)almost always spontaneously resolves Delayed or missed diagnosis is common when evaluation not performed by an orthopaedic surgeon complication rates and severity increase if diagnosis delayed >2-3 weeks