- Antibiotics play an important role in preventing and treating infections in orthopedic surgery and injuries. The document discusses protocols for antibiotics in open fractures, surgical prophylaxis, and bone infections.
- For open fractures, the antibiotic protocol depends on the Gustilo classification and wound characteristics. For surgical prophylaxis, timing, antibiotic choice (usually cefazolin), and duration (no more than 24 hours after surgery) are discussed.
- Bone infections require coverage of likely pathogens, with protocols varying based on factors like patient age, infection origin, and presence of implants. Duration typically lasts 4-6 weeks depending on the infection.
2. Infection in orthopedic surgery is one of the most
dreaded complications.
It is associated with prolonged morbidity, disability
and increased mortality.
Out of nearly 30 million operations in the United
States each year more than 2% are complicated with
surgical site infections.
The mortality rate increases 23 times after
infection.
3. Antibiotics are the cornerstone of prevention
and management of orthopedics infection.
We will discuss protocols of antibiotics in
1. Open fractures
2.Surgical prophylaxis
3. Bone infection
4. Protocol of Antibiotics in open fractures
Gustilo type 1 and 2
First generation cephalosporin for 24 hours
Type 3A
First generation cephalosporin plus a
aminoglycoside since 72 hours since last incision
and drainage
Type 3B highly contaminated farm injuries
First generation cephalosporin plus aminoglycoside
plus high dose penicillin 72 hours since last
incision and drainage
5. Freshwater wounds
Flouroquinolones or third or fourth generation
cephalosporin
Saltwater wounds
Doxycycline and fourth generation
cephalosporin or flouroqunolones
6. Protocol for Surgical prophylaxis
There is enough evidence to say that prophylactic
antibiotics should be used in orthopedics to reduce
surgical site infection
We will discuss timing,choice and duration of
antibiotics for prophylaxis in surgical patients
7. Timing of administration
The timing of administration remains controversial.
Evidence shows that initiating prophylaxis after the
skin is incised, is ineffective.
Most of the studies agree that prophylactic
antibiotics should ideally be administered 3060 min
before skin incision
Administration >60 min before surgery/incision is
associated with higher risk of surgical infections
8. The prophylaxis has least effect when
antibiotic is given after the application of a
tourniquet
9. Which antibiotics?
The antibiotic selected should in general, be
inexpensive, nontoxic and of limited spectrum.
The most prevalent organisms in prosthetic related
infections are Gram-positive Staphylococcus
aureus and epidermidis
10. According to American Society of Health
System Pharmacists (ASHP) cefazolin was the
most used antibiotic in preoperative
prophylaxis, combination of cefazolin with
gentamicin was the second common regimen
while 3rd generation cephalosporin were
3rd widely used antibiotics.
11. In a study, 3rd generation cephalosporins were most
commonly used for arthroplasty prophylaxis and
2nd generation cepholospirins were used for fracture
fixation.
12. Duration of antibiotics
The controversy persists in administration of
antibiotics varying from a single dose to 3 doses to 5
days or 14 days
The ideal duration of postoperative antibiotics is not
yet clearly defined although most reports say that
there is no additional benefit when prophylactic
antibiotics are given more than 24 h postsurgery
13. Musmar et al. suggests that antibiotics should be
discontinued within 24 h after end of surgery to
prevent emergence of resistance
Thonse et al. recommended prophylactic antibiotic
regimen at time of induction of anesthesia and two
subsequent doses at 8 and 16 h postoperatively.
Another study by Andersson et al. suggest same
recommendations of 3 doses within 24 h.
14. Niimi et al. in a retrospective study compared the outcome of
1-day intravenous administration with that of long term
intravenous administration in arthroplasty cases. They used
antibiotics for 1-day (n = 233) and for at least 3 days (n = 104)
None of these patients developed wound infection during
follow up (minimum 12 months).
They concluded that 1-day antibiotic infusion was as effective
as long term antibiotic infusion preventing infection after
arthroplasty.
15. Protocol of antibiotics in osteomyelitis
Empirical antibiotics
Coverage for the most likely infecting organism
should be started till gram stain results appear or if
negative.
Recommendations for the initiation of empiric
antibiotic (according to age of the patient and
mechanism of infection
16. Hematogenous osteomyelitis ( newborn to adult
combination of penicillinase-resistant synthetic
penicillin (Oxacillin or nafcillin) +third-generation
cephalosporin.
MRSA
vancomycin or clindamycin +third-generation
cephalosporin, Linezolid is also used in these
circumstances.
17. Sickle cell disease:S aureus and Salmonellae species--
----fluoroquinolone antibiotic (not in children).
A third-generation cephalosporin (eg, ceftriaxone) is
an alternative choice
In diabetic foot----S aureus and Pseudomonas
aeruginosa----ceftazidime or cefepime. Ciprofloxacin
is an alternative treatment.
18. Prosthesis infections S epidermidis----biofilm----
protect bacteria against phagocytosisd antibiotics.
Rifampicin: Must be used in combination with other
antibiotics because it acts on the biofilm and avoids
recurrence if used within a month of treatment
19. Start IV: The response to appropriate IV antibiotic
usually occur in 48 hr
Lack of improvement in fever and pain after this -----
surgical drainage.
Then use IV (according to culture) for 2 weeks
Oral (combination) for 4 weeks --(revascularization of
bone takes 4 weeks
20. Duration of antibiotic therapy
Most infections- eg S. aureus, a total of 6 wk.
For group A streptococcus, S. pneumoniae, or
H. influenzae type b---, shorter.
Immunocompromised patients, mycobacterial
or fungal infection ---- prolonged courses of
therapy.
22. Radial head dislocation plus proximal ulna
fracture or
Plastic deformation of the ulna without
obvious fracture
Peak age is 4-10 years in children
24. Bado Classification
Type I ulna fracture with anterior
dislocation of the radial head
25. Type II proximal ulna fracture with posterior
dislocation of the radial head
26. Type III proximal ulna fracture with lateral
dislocation of the radial head
27. Type IV Fractures of both the radius and
ulna at the same level with an anterior
dislocation of the radial head (1-11% of cases)
28. Monteggia equivalents
isolated radial head dislocation with plastic
deformity of ulna
fracture of the proximal ulna with fracture of
the radial neck, and
Both bone proximal third fractures with the
radial fracture more proximal than the ulnar
fracture
29. Imaging
Obtain standard AP and lateral views
Assess radiocapitellar line on every lateral
radiograph of the elbow
A line down the radial shaft should pass
through the center of the capitellar
ossification center in all elbow positions
32. Treatment
closed reduction of ulna and radial head
dislocation and long arm casting
Indicated for BADO I-III when
1.Radial head is stable following
reductions
2. Length stable ulnar fracture pattern
33. Radial head will reduce spontaneously with
reduction of the ulna and restoration of ulnar length
Patients should be immobilized in a long arm cast in
90 to 100 degrees of flexion and supination and
followed closely radiographically for 2 to 3 weeks to
ensure maintenance of radial head reduction.
34. Operative
Plating of ulna + reduction of radial head 賊 annular
ligament repair/reconstruction
Indication
Bado Types I-III with
radial head is not stable following reduction
ulnar length is not stable (unable to maintain ulnar length)
acute Bado Type IV
open fractures
older patients 10y if closed reduction is not stable
35. Technique
Annular ligament reconstruction almost never
required for acute fractures
open reduction of radial head through a lateral
approach if needed in chronic (>2-3 weeks old)
Monteggia fractures where radial head still retains
concave structure
Chronic Monteggia requires ulnar osteotomy with
annular ligament reconstruction via triceps tendon
harvesting
37. Complications
posterior interosseous nerve neuropraxia (10% of
acute injuries)almost always spontaneously resolves
Delayed or missed diagnosis is common when
evaluation not performed by an orthopaedic surgeon
complication rates and severity increase if diagnosis
delayed >2-3 weeks