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BIOCHEMISTRY QUESTIONS
(MSc Entrance AIIMS)
Dr. Pooja Johri
PhD Biochemistry

? Which of the following is an example of attenuated vaccine?]
1. Tetanus
2. Hepatitis B
3. Yellow fever
4. Meningococcal

? Albinism is caused by the deficiency of
1. Tyrosinase
2. HMG CoA reductase
3. Phenylalanine hydroxylase
4. Arginase

3. The flow of electrons through the respiratory chain is uncoupled by
which of the following:
1. Thermogenin
2. Carbon monoxide
3. Oligomycin
4. Cyanide

4. An adult female was prescribed statins, which are a class of
cholesterol reducing drugs. Which of the following is the target of these
drugs?
1. ALT
2. Lipase
3. HMG CoA reductase
4. Cholecalciferol

5. Who discovered and described the blood groups (ABO) classification
1. Theodor Kocher
2. Karl Hooper
3. Otto Warburg
4. Karl Landsteiner

6. Which of the following is the correct combination of marker enzymes used
to identify different organelles during subcellular fractionation of eukaryotic
tissue?
1. Cytosol-Catalase; Mitochondria-Succinate Dehydrogenase; Lysosome-
Acid phosphatase; Peroxisome-Lactate Dehydrogenase
2. Cytosol-Acid phosphatase; Mitochondria-Succinate Dehydrogenase;
Lysosome-Lactate Dehydrogenase; Peroxisome-Catalase
3. Cytosol-Lactate Dehydrogenase; Mitochondria-Succinate
Dehydrogenase; Lysosome-Acid phosphatase; Peroxisome-Catalase
4. Cytosol-Succinate Dehydrogenase; Mitochondria-Lactate
Dehydrogenase; Lysosome-Acid phosphatase; Peroxisome-Catalase

7. Which of the following scientist was awarded Nobel Prize in
Physiology or Medicine 1987 for his discovery of the genetic principle
for generation of antibody diversity?
1. Neils Jerne
2. Susumu Tonegawa
3. Gerald Edelman
4. Frank Macfarlane Burnet and Peter Medawar

8. Which of the following sequences are not palindromic?
1. ATGCATATGCAT
2. GGCCAATTGGCCAA
3. TTAAGGATCCTTAA
4. AGCGAATTCGCT

9. Which of the following statements about the formation of uric acid is
correct?
1. Uric acid levels are increased by increasing the activity of the
salvage pathway.
2. Overproduction of uric acid levels in hypoxanthine-guanine
phosphoribosyl transferase (HGPRT) deficiency.
3. No change in the uric acid levels.
4. Uric acid levels are reduced by a deficiency of hypoxanthine-
guanine phosphoribosyl transferase (HGPRT).

10. Malonyl-CoA is an inhibitor of
1. Carnitine Acyl Transferase II
2. Carnitine Acyl Transferase I
3. Fatty acid synthase
4. Thiokinase

11.Which of the following is true for allosteric inhibition of an enzyme?
1. It always leads to a reduced binding of substrate
2. The inhibitor binds to some other site than the active site of the
enzyme
3. The inhibitor binds to the active site of the enzyme
4. It causes the enzyme to work faster

12. Folic acid is important for
1. Fatty acid oxidation
2. Fatty acid synthesis
3. Gluconeogenesis
4. One carbon metabolism

13. AB is a substrate for enzyme D which converts AB to AC. In the
presence of an competitive inhibitor E in place of substrate AB, the
enzyme��s,
1. Km increases and Vmax remains same
2. Km increases and Vmax decreases
3. Km decreases and Vmax increases
4. Km and Vmax both remains same

14. The rate limiting step of urea cycle is mediated by
1. Arginase
2. Carbamoyl phosphate synthetase I
3. Arginosuccinate synthetase
4. Ornithine transcarbamoylase

15. The process by which an amino acid catabolizes its carbon chain
into acetoacetyl CoA is considered to be
1. Glycogenic
2. Both glycogenic and ketogenic
3. Neither glycogenic nor ketogenic
4. Ketogenic

16. Lactose deficiency is characterized by the inability to hydrolyze:
1. Alpha-1,4-glycosidic bonds
2. Beta-1,6-galactosidic bonds
3. Beta-1,4-glycosidic bonds
4. Beta-1,4-galactosidic bonds

17. What happens if citrate concentration is increased during glycolysis
1. Inhibits triose phosphate isomerase and increase glycolysis
2. Inhibits phosphoglycerate kinase and slows down glycolysis
3. Inhibits phosphofructokinase and slows down glycolysis
4. Inhibits phosphofructokinase and increases glycolysis

18. S-Adenosyl methionine is required for the synthesis of which of the
following?
1. Serotonin
2. Melanin
3. Thyroid hormone
4. Epinephrine

19. The active site of chymotrypsin consists of a catalytic triad
composed of which of the following amino acid residues?
1. Serine, histidine and aspartate
2. Serine, histidine and glutamate
3. Threonine, histidine and aspartate
4. Methionine, histidine and aspartate

? Chymotrypsin is an endopeptidase, cleaving proteins of Aromatic A.A
residues ( Serine Protease).
? Tyrosine, Tryptophan or Phenylalanine.
? Has Serine (195). Histidine (57) and Aspartic Acid (102).

20. Lovastatin is a
1. Competitive inhibitor of HMG CoA synthetase
2. Non-competitive inhibitor of HMG CoA reductase
3. Competitive inhibitor of acetyl CoA carboxylase
4. Competitive inhibitor of HMG CoA reductase

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M.Sc entrance AIIMS

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