Blood-borne pathogens present a risk of disease transmission to workers through contact with infected blood or bodily fluids. The presentation defines blood-borne pathogens as infectious microorganisms in human blood and other potentially infectious materials that can cause diseases. It identifies the main blood-borne pathogens as HIV, Hepatitis B, and Hepatitis C and discusses how they are transmitted occupationally through contact with mucous membranes, non-intact skin, or sharps injuries. The presentation outlines the key elements of protection against blood-borne pathogens as awareness, engineering and work practice controls, and personal protective equipment. It also describes the essential components of a blood-borne pathogen program for workplaces.