![BEERS CRITERIA:
1.NITROFURANTOIN不建議用在65歲以上的長輩~
因其肺臟、肝臟與神經副作用,尤其是長期使用更明
顯
2.肌酸酐清除率<30 ML/MINUTE ,不要使用
NITROFURANTOIN,因為體內濃度會升高很多
Nitrofurantoin is identified in the Beers Criteria as a potentially
inappropriate medication to be avoided in patients 65 years and older
(independent of diagnosis or condition) due to its potential for pulmonary
toxicity, hepatotoxicity and peripheral neuropathy, particularly when given
long-term; safer alternatives exist. Avoid use in patients with a CrCl less
than 30 mL/minute or for long-term suppressive therapy (Beers Criteria
[AGS 2019]).](https://image.slidesharecdn.com/nitrofurantoin-220722222059-61400cf5/85/Nitrofurantoin-15-320.jpg)
老人用药狈颈迟谤辞蹿耻谤补苍迟辞颈苍
- 2. 剂量
- 5. 作用
- 7. 藥物動力學 1.吸收: 隨餐服能提高40%的吸收 2.代謝: 身體組織會將60%的藥物轉化成非活性代謝 物 3.排除: 有40%的藥物會從尿液排除,所以用在泌尿道 感染
- 8. 用途
- 9. 尿路感染症 膀胱炎
- 10. 長輩要小心的 副作用
- 12. 角色
- 13. ? 泌尿道感染, NITROFURANTOIN和現在常用的 抗生素(PENICILLINS、CEPHALOSPORINS、 TMP/SMX、QUINOLONES)比起來,在膀胱外的 濃度會不夠,而且對長輩的副作用風險也比較高 ? 所以NITROFURANTOIN目前在醫院比較少使 用了
- 14. 给长辈的建议
- 15. BEERS CRITERIA: 1.NITROFURANTOIN不建議用在65歲以上的長輩~ 因其肺臟、肝臟與神經副作用,尤其是長期使用更明 顯 2.肌酸酐清除率<30 ML/MINUTE ,不要使用 NITROFURANTOIN,因為體內濃度會升高很多 Nitrofurantoin is identified in the Beers Criteria as a potentially inappropriate medication to be avoided in patients 65 years and older (independent of diagnosis or condition) due to its potential for pulmonary toxicity, hepatotoxicity and peripheral neuropathy, particularly when given long-term; safer alternatives exist. Avoid use in patients with a CrCl less than 30 mL/minute or for long-term suppressive therapy (Beers Criteria [AGS 2019]).
- 16. PHARMACY QUALITY ALLIANCE (PQA): 65歲以上的長輩,若連續使用NITROFURANTOIN 90天以上,算是高風險情形~產生毒性 Nitrofurantoin (when cumulative day supply is greater than 90 days) is identified as a high-risk medication in patients 65 years and older on the PQA's Use of High-Risk Medications in the Elderly (HRM) performance measure, a safety measure used by the Centers for Medicare and Medicaid Services (CMS) for Medicare plans (PQA 2017).