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Non Steroidal Anti Inflammatory Drugs

Quazi Istiaque Bari
Quazi Istiaque Bari

Nonsteroidal anti-inflammatory drugs, or NSAIDs (pronounced en-saids), are the most prescribed medications for treating conditions such as arthritis. Most people are familiar with over-the-counter, nonprescription NSAIDs, such as aspirin and ibuprofen. NSAIDs are more than just pain relievers. here you will find the Classification of NSAIDs & Mechanism of action of NSAIDs.

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KHWAJA YUNUS ALI UNIVERSITY QUEST FOR KNOWLEDGE Assignment On NSAIDs Course Name: Advanced Medicinal Chemistry Course Code: BPH 4101 Submitted By: Submitted To: Date of Submission: 10-08-2020 Naznin Shahria Senior Lecturer Department Of Pharmacy Khwaja Yunus Ali University Quazi Istiaque Bari ID No: 2017301030007 4th year 1st semester Batch- 8th Department Of Pharmacy Khwaja Yunus Ali University
NSAIDs Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Example- Aspirin, paracetamol, ibuprofen, ketoprofen, diclofenac etc. Classification of NSAIDs: A. Nonselective COX inhibitors (traditional NSAIDs) 1. Salicylates: Aspirin. 2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen. 3. Fenamate: Mephenamic acid. 4. Enolic acid derivatives: Piroxicam, Tenoxicam. 5. Acetic acid derivatives: Ketorolac, Indomethacin, Nabumetone 6. Pyrazolone derivatives: Phenylbutazone, Oxyphenbutazone. B. Preferential COX-2 inhibitors Nimesulide, Diclofenac, Aceclofenac, Meloxicam, Etodolac. C. Selective COX-2 inhibitors Celecoxib, Etoricoxib, Parecoxib D. Analgesic-antipyretics with poor antiinflammatory action 1. Paraaminophenol derivative: Paracetamol (Acetaminophen). 2. Pyrazolone derivatives: Metamizol (Dipyrone), Propiphenazone. 3. Benzoxazocine derivative: Nefopam.
Mechanism of action of NSAIDs: COX-2 (Inducible) NSAIDs Prostaglandins Prostaglandins GI protection Platelet activation Inflammation Fever Pain Cell damage Membrane phospholipid Arachidonic acid Flow chart of mechanism of action of NSAIDs

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Non Steroidal Anti Inflammatory Drugs

  • 1. KHWAJA YUNUS ALI UNIVERSITY QUEST FOR KNOWLEDGE Assignment On NSAIDs Course Name: Advanced Medicinal Chemistry Course Code: BPH 4101 Submitted By: Submitted To: Date of Submission: 10-08-2020 Naznin Shahria Senior Lecturer Department Of Pharmacy Khwaja Yunus Ali University Quazi Istiaque Bari ID No: 2017301030007 4th year 1st semester Batch- 8th Department Of Pharmacy Khwaja Yunus Ali University
  • 2. NSAIDs Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Example- Aspirin, paracetamol, ibuprofen, ketoprofen, diclofenac etc. Classification of NSAIDs: A. Nonselective COX inhibitors (traditional NSAIDs) 1. Salicylates: Aspirin. 2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen. 3. Fenamate: Mephenamic acid. 4. Enolic acid derivatives: Piroxicam, Tenoxicam. 5. Acetic acid derivatives: Ketorolac, Indomethacin, Nabumetone 6. Pyrazolone derivatives: Phenylbutazone, Oxyphenbutazone. B. Preferential COX-2 inhibitors Nimesulide, Diclofenac, Aceclofenac, Meloxicam, Etodolac. C. Selective COX-2 inhibitors Celecoxib, Etoricoxib, Parecoxib D. Analgesic-antipyretics with poor antiinflammatory action 1. Paraaminophenol derivative: Paracetamol (Acetaminophen). 2. Pyrazolone derivatives: Metamizol (Dipyrone), Propiphenazone. 3. Benzoxazocine derivative: Nefopam.
  • 3. Mechanism of action of NSAIDs: COX-2 (Inducible) NSAIDs Prostaglandins Prostaglandins GI protection Platelet activation Inflammation Fever Pain Cell damage Membrane phospholipid Arachidonic acid Flow chart of mechanism of action of NSAIDs