This document announces a continuing medical education event presented by the National Patient Safety Foundation on November 16, 2011 about diagnostic errors in medicine. The event features two speakers: Richard Anderson, MD, who will discuss the importance of diagnostic errors, their costs and consequences; and Mark Graber, MD, who will perform a root cause analysis of factors known to contribute to diagnostic errors. The learning objectives are to help attendees identify diagnostic error as a risk, discuss its importance, analyze root causes, and learn tools to reduce diagnostic errors. The document provides background information on estimates of diagnostic error rates from different studies and settings.
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1. NPSF Professional Learning Series presents:
The new kid on the patient safety block:
Diagnostic Error in Medicine
November 16, 2011
Richard E. Anderson, M.D., F.A.C.P Mark L Graber MD FACP
Chairman and Chief Executive Officer Senior Scientist, Patient Safety
Portfolio, RTI International
The Doctors Company
Professor Emeritus, Dept of Medicine,
SUNY Stony Brook, NY
mgraber@rti.org
2. Participant Notification
ACKNOWLEDGEMENT OF COMMERCIAL SUPPORT: There was no commercial support received for this CME activity.
CONTINUING EDUCATION
Physicians: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the
Accreditation Council for Continuing Medical Education through the joint sponsorship of the Institute for the Advancement of Human
Behavior (IAHB) and the National Patient Safety Foundation (NSPF). The IAHB is accredited by the ACCME to provide continuing
medical education for physicians.
AMA PRA Statement: The IAHB designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit(s)
Physicians should only claim credit commensurate with the extent of their participation in the activity.
Nurses:
IAHB is an approved provider of continuing nursing education by the Utah Nurses Association, an accredited
Approver by the American Nurses Credentialing Centers Commission on Accreditation. Provider Code P09-03.
This course is co-provided by IAHB and the National Patient Safety Foundation. Maximum of 1 contact hour. Approved status as a
provider refers only to its continuing education activities and does not imply UNA or ANCC Commission on Accreditation
endorsement of any commercial products.
Pharmacists:
Amedco is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy
education. 1
contact hour. UAN: 0453-9999-11-046-L05-P (K)
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NPSF Professional Learning Series November 16, 2011
3. Disclosure
All faculty/speakers, planners, abstract reviewers, moderators, authors, co-authors and administrative staff participating in the
continuing medical education programs jointly sponsored by IAHB are expected to disclose to the program audience any/all
relevant financial relationships related to the content of their presentation(s).
The following disclosures of financial relationships have been made by the program planners and presenters:
Last Name First Name Disclosure Resolution Off-Label Use
Perry Allison N N/A N/A
Grubbs Kenneth N N/A N/A
Parker Jay N N/A N/A
Chrobak Bernice N N/A N/A
Graber Mark N N N
Anderson Richard N N/A N
Financial Relationship Key:
G-Grant/Research Support
C-Consultant/Scientific Advisor
S-Speakers Bureau
E-Employee
O-Other
N-Nothing to disclose
Resolution Key
R1-Restricted to Best Available Evidence & ACCME content validation statement
R2-Removed/Altered Financial Relationship
R3-Altered Control
R4-Peer Review with 2nd method of resolution
Questions?
Contact Us at info@npsf.org or 617-391-9900
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NPSF Professional Learning Series November 16, 2011
4. Learning objectives
* Identify diagnostic error as a major element of risk in
their practices
* Discuss the importance of diagnostic error
including the costs and consequences to patients and
organizations
* Perform a root cause analysis based on the factors
known to contribute to diagnostic error
* Use tools provided to reduce the risks of diagnostic
error in their own practice or organization
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NPSF Professional Learning Series November 16, 2011
5. NPSF Professional Learning Series presents:
The new kid on the patient safety block:
Diagnostic Error in Medicine
November 16, 2011
Richard E. Anderson, M.D., F.A.C.P Mark L Graber MD FACP
Chairman and Chief Executive Officer Senior Scientist, Patient Safety
Portfolio, RTI International
The Doctors Company
Professor Emeritus, Dept of Medicine,
SUNY Stony Brook, NY
mgraber@rti.org
6. Diagnostic Errors
Falls
Wrong Site
Med Errors Surgery
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NPSF Professional Learning Series November 16, 2011
7. Nurses:
Its not MY problem !
Hospitals:
Its not OUR
problem !
Doctors:
I dont make
mistakes !
Diagnostic errors fall in our collective blind spot
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8. DxNos
Tician
MD
Diagnosis: The most critical of a physicians skills. It is every
doctors measure of his abilities; it is the most important ingredient
in his professional self image.
Pat Croskerry - 2008
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9. Estimates of the Diagnostic Error Rate
Pathology, Although higher numbers can be found under artificial
Radiology conditions, the estimated error rate in the real world is
near 2%
Clinical Lab Varies by test, lab, etc, but overall error rate is < .1%
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NPSF Professional Learning Series November 16, 2011
10. Estimates of the Diagnostic Error Rate
Patient One third of patients relate a Dx error that affected
Surveys themselves, a family member, or close friend
Second 10-30% of breast cancers are missed on
reviews mammography;1-2% of cancers misread on biopsy
samples
Standard pts Internists misdiagnosed 13% of patients presenting with
common conditions to clinic (COPD, RA, others)
Look backs 30% of subarrachnoid hemorrhage misdiagnosed; 39%
of dissecting AAA delayed diagnosis; 25-50% of women
with cervical cancer last PAP abnl on re-read
Autopsies Major unexpected discrepancies that would have
changed the management are found in 10-20%
Expert guess Arthur Elstein: 10%
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11. The death of one man is a tragedy,
the death of millions is a statistic.
Joseph Stalin (?)
Maurice Gibb
John Ritter
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12. Where do these
errors happen ?
What are the
common
conditions ?
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13. Inpatient Settings
% adverse events related to diagnostic error:
Harvard Medical Practice Study: 17%
Colorado & Utah: 7%
Canadian Adverse Event: 10%
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14. Diagnostic Error in Ambulatory Settings
Systematic Review of 21 publications:
Cancer In a series of 56 cases, 8 had serious delays in dx
DementiaEvery pt in a small town was screened: 9% had dementia but only
4% had been diagnosed
Fe-def anemia High incidence of non-investigation & missed cancer, esp females.
Asthma Median delay making the Dx: 3 years, 7 visits
Tremor Of 402 pts with presumed Parkinsons, dx correct in only half
Error-promoting factors:
Atypical & nonspecific presentations
Rare conditions
Comorbid conditions
Kostopoulou, Delaney and Munro. Diagnostic difficulty and error in primary
care A systematic review. Family Practice 400-413, 2008
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15. Diagnosis cases %
Pulmonary embolism 26 4.5%
Poisoning, ADR, overdose 26 4.5%
Lung cancer 23 3.9%
Schiff, G. D., O. Hasan, et
al. (2009). Colorectal cancer 19 3.3%
Diagnostic Error in Acute coronary syndrome 18 3.1%
Medicine - Analysis of 583 Breast cancer 18 3.1%
Physician-Reported Errors.
Arch Int Med 169(20): Stroke 15 2.6%
1881-1887. Congestive heart failure 13 2.2%
Fracture 13 2.2%
Abscess 11 1.9%
Pneumonia 10 1.7%
Aortic aneurysm/dissection 9 1.5%
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16. What is the cost of
diagnostic error ?
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17. Claims Data: High-severity Cases
Top allegation category: Diagnosis Error
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18. The rising cost of diagnosis
Igelhart NEJM 2009. Vol 360 p1030
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19. Costs and consequences of Dx Error
Inappropriate testing (Defensive medicine)
Preventable re-admissions; Preventable
return visits to the ER; Preventable rescue
events.
Physical and psychological harm
False positives: Your mammogram shows a
nodule I think you have cancer
False negatives: Your chest pain sounds
musculoskeletal (or is it a heart attack ?)
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20. How can we
analyze and
understand
diagnostic error ?
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21. History Exam
Diagnosis
Tests
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22. Where & When in Dx Process are Errors Occurring?
Present; F/up
1%
Assessment
33% History
10%
Exam
10%
Lab & Radiol
Testing
46%
N= 583 Cases
Schiff, G. D., O. Hasan, et al. (2009). "Diagnostic Error in Medicine - Analysis
of 583 Physician-Reported Errors." Arch Int Med 169(20): 1881-1887.
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23. What went wrong ?
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24. Missed and Delayed Diagnoses in the Ambulatory Setting
Gandhi et al. Ann Int Med 2006. 145:488-496
Analyzed 307 closed malpractice claims involving
an outpatient diagnostic error from 4 carriers
Of the 307 cases:
55% failure to obtain an appropriate test
45% failure to create an appropriate plan for
follow-up
42% failure to obtain the appropriate history or
physical exam
37% incorrect interpretation of diagnostic tests
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25. The
Healthcare
System
The
Clinician
The Patient
HARM
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26. Average: 6 distinguishable errors/case
Etiology of Diagnostic Error
No Fault Error Only
7%
Both System and System Error Only
Cognitive Errors 19%
46%
Cognitive Error Only
28%
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27. System-Related Diagnostic Error
DOMAIN EXAMPLE
Communication Critical information not passed to the
next provider
Coordination of Care Medical records not available
Access to Experts No Radiologist on nights
Safety Culture Same errors keep happening
Supervising Trainees Trainee misdiagnosis at night
Work Pressure Rushed history missed key piece of
data
Distractions, etc Fatigue, interruptions causing slips
Diagnostic Testing Pre- and Post-analytical errors
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28. Cognitive-Based Diagnostic Error
DOMAIN EXAMPLE
Inadequate knowledge Doctor didnt know the disease could
present this way
Faulty data collection Sloppy physical exam; failing to
review the existing medical records
Faulty synthesis Faulty context and anchoring errors;
Premature closure (failing to consider
other possibilities)
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29. Say Whats a mountain goat doing
way up here in a cloud bank ? 29
NPSF Professional Learning Series November 16, 2011
30. Premature closure = Satisficing
= Falling in love with the first puppy
(Herbert Simon)
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31. So where are we ?
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32. Diagnostic Errors
Are more common than they should be. They
cause enormous harm and lost costs.
Typically involve multiple breakdowns in our
safety systems, and involve both cognitive and
system-related issues. They can be analyzed
using RCA approaches like any other medical
error
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33. What can we do to
reduce the
likelihood of
diagnostic error ?
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34. AHRQ: Literature Review to Identify Interventions
to Reduce Dx Error
Mark Graber, Hardeep Singh
RTI International
Systems: 43 articles: 6 trials
Cognitive: 157 articles: 37 trials
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35. Strategies to Reduce Dx Error
HEALTHCARE SYSTEMS
Promote a culture of safety
Address the common system flaws to
contribute to diagnostic error
Provide decision support resources
Encourage second opinions
Develop pathways for feedback
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NPSF Professional Learning Series November 16, 2011
36. Strategies to Reduce Dx Error
HEALTHCARE SYSTEMS
IMPROVE COMMUNICATION
Take advantage of the EMR
Better alerts for critical test results; Better data displays
Make sure expertise is available when needed
Coordinate care across different providers, sites, systems
Making sure prior medical data is available for review
Empowering patients; Encourage feedback
Ensure screening tests are done
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37. Strategies to Reduce Dx Error
NURSES Our Safety Net
Help minimize system flaws:
Ensure good communication
Help ensure test results are acted upon
Help the patient communicate
Be the watchdog for deterioration
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38. Strategies to Reduce Dx Error
PATIENTS
Be a good historian
Keep accurate records of your tests
SPEAK UP ! What else could this be ?
Get real: Diagnosis is just playing the odds
Ask what to expect & what the plan is for
follow-up
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NPSF Professional Learning Series November 16, 2011
39. Strategies to Reduce Dx Error
PHYSICIANS
System errors: Bring them to attention
and make sure they get fixed.
Cognitive errors:
Improve your knowledge base
Improve your clinical reasoning & use EBM
Take advantage of decision support resources
and get help when needed
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NPSF Professional Learning Series November 16, 2011
40. NOVICE
more
Monitoring,
Inductive antidotes
Reasoning
GET HELP
REFLECTIVE PRACTICE
Cost
Heuristics,
Automatic
Time
ME EXPERT
Effort
Expert
Thinking
less more
Accuracy, Reliability
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41. Problems Solutions
Faulty context Reflection What else
Premature closure could this be ?
Failed intuition Be comprehensive
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42. How to be Comprehensive
Use mnemonics and tricks:
ROWCS
VITAMIN C C & D
Electronic decision support
(Isabel, DxPlain)
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43. VITAMIN C C & D
V ascular
I nfections & intoxications
T rauma & toxins
A uto-immune
M etabolic
I diopathic & iatrogenic
N eoplastic
C ongenital
C onversion (psychiatric)
D egenerative
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45. A Checklist for Diagnosis
Obtain YOUR OWN, COMPLETE medical history, & a FOCUSED and
PURPOSEFUL physical examination
Generate some initial hypotheses; Use EBM;
Pause to reflect Take a diagnostic time out:
Was I comprehensive ?
Did I consider the inherent flaws of heuristic thinking ?
Was my judgment affected by any other bias ?
Do I need to make the diagnosis NOW, or can I wait ?
Whats the worst case scenario ? What are the dont miss entities ?
Embark on a plan, but acknowledge uncertainty and
ENSURE A PATHWAY FOR FOLLOW-UP
Make the PATIENT your PARTNER
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NPSF Professional Learning Series November 16, 2011
46. NPSF Education Module:
Reducing Diagnostic Error
Lectures from Gordy Schiff, Geetha Singhal, Mark Graber
Workshop on diagnostic error
Patient and Family Tools and Resources
Pocket Guide How Doctors Think
Ask Me 3
1. Have I told you enough so you can understand my problem?
2. What could be causing my problem?
3. When will I get my test results, and will my other doctors get
the results too?
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NPSF Professional Learning Series November 16, 2011
47. In Summary
Diagnostic error is a common and serious
problem, causing enormous harm
These errors reflect latent system flaws and
shortcomings in cognition
The problem is largely ignored by all concerned
ITS TIME TO DO SOMETHING ..
And THERES A JOB FOR EVERYONE
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NPSF Professional Learning Series November 16, 2011