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NSAIDs classification & mechanism of action

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Quazi Istiaque Bari
Quazi Istiaque Bari

Search Results Featured snippet from the web Nonsteroidal anti-inflammatory drugs, or NSAIDs (pronounced en-saids), are the most prescribed medications for treating conditions such as arthritis. Most people are familiar with over-the-counter, nonprescription NSAIDs, such as aspirin and ibuprofen. NSAIDs are more than just pain relievers. Here is the short note on NSAIDs. If any incorrect details provided here please correct it in the comment section. It will help you & me also

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KHWAJA YUNUS ALI UNIVERSITY QUEST FOR KNOWLEDGE……… Assignment On NSAIDs Course Name: Advanced Medicinal Chemistry Course Code: BPH 4101 Submitted By: Submitted To: Date of Submission: 10-08-2020 Naznin Shahria Senior Lecturer Department Of Pharmacy Khwaja Yunus Ali University Quazi Istiaque Bari ID No: 2017301030007 4th year 1st semester Batch- 8th Department Of Pharmacy Khwaja Yunus Ali University
NSAIDs Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Example- Aspirin, paracetamol, ibuprofen, ketoprofen, diclofenac etc. Classification of NSAIDs: A. Nonselective COX inhibitors (traditional NSAIDs) 1. Salicylates: Aspirin. 2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen. 3. Fenamate: Mephenamic acid. 4. Enolic acid derivatives: Piroxicam, Tenoxicam. 5. Acetic acid derivatives: Ketorolac, Indomethacin, Nabumetone 6. Pyrazolone derivatives: Phenylbutazone, Oxyphenbutazone. B. Preferential COX-2 inhibitors ï‚· Nimesulide, ï‚· Diclofenac, ï‚· Aceclofenac, ï‚· Meloxicam, ï‚· Etodolac. C. Selective COX-2 inhibitors ï‚· Celecoxib, ï‚· Etoricoxib, ï‚· Parecoxib D. Analgesic-antipyretics with poor antiinflammatory action 1. Paraaminophenol derivative: Paracetamol (Acetaminophen). 2. Pyrazolone derivatives: Metamizol (Dipyrone), Propiphenazone. 3. Benzoxazocine derivative: Nefopam.
Mechanism of action of NSAIDs: COX-2 (Inducible) NSAIDs Prostaglandins Prostaglandins GI protection Platelet activation Inflammation Fever Pain Cell damage Membrane phospholipid Arachidonic acid Flow chart of mechanism of action of NSAIDs

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NSAIDs classification & mechanism of action

  • 1. KHWAJA YUNUS ALI UNIVERSITY QUEST FOR KNOWLEDGE……… Assignment On NSAIDs Course Name: Advanced Medicinal Chemistry Course Code: BPH 4101 Submitted By: Submitted To: Date of Submission: 10-08-2020 Naznin Shahria Senior Lecturer Department Of Pharmacy Khwaja Yunus Ali University Quazi Istiaque Bari ID No: 2017301030007 4th year 1st semester Batch- 8th Department Of Pharmacy Khwaja Yunus Ali University
  • 2. NSAIDs Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain, decreases fever, prevents blood clots, and in higher doses, decreases inflammation. Example- Aspirin, paracetamol, ibuprofen, ketoprofen, diclofenac etc. Classification of NSAIDs: A. Nonselective COX inhibitors (traditional NSAIDs) 1. Salicylates: Aspirin. 2. Propionic acid derivatives: Ibuprofen, Naproxen, Ketoprofen, Flurbiprofen. 3. Fenamate: Mephenamic acid. 4. Enolic acid derivatives: Piroxicam, Tenoxicam. 5. Acetic acid derivatives: Ketorolac, Indomethacin, Nabumetone 6. Pyrazolone derivatives: Phenylbutazone, Oxyphenbutazone. B. Preferential COX-2 inhibitors ï‚· Nimesulide, ï‚· Diclofenac, ï‚· Aceclofenac, ï‚· Meloxicam, ï‚· Etodolac. C. Selective COX-2 inhibitors ï‚· Celecoxib, ï‚· Etoricoxib, ï‚· Parecoxib D. Analgesic-antipyretics with poor antiinflammatory action 1. Paraaminophenol derivative: Paracetamol (Acetaminophen). 2. Pyrazolone derivatives: Metamizol (Dipyrone), Propiphenazone. 3. Benzoxazocine derivative: Nefopam.
  • 3. Mechanism of action of NSAIDs: COX-2 (Inducible) NSAIDs Prostaglandins Prostaglandins GI protection Platelet activation Inflammation Fever Pain Cell damage Membrane phospholipid Arachidonic acid Flow chart of mechanism of action of NSAIDs