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Nutrition Support  Special Considerations in NeonatesSajjad Ahmad RPh. BCNSPTPN Pharmacist, In-Charge IV Admixture ServicesKFSH&RC Jeddah K.S.A(May 2009)
2
Defining Neonates In Terms Of Weight3
Nutrition Support In NICU4Nutrition Support is applied inappropriately in NICU11. A.S.P.E.N Nutrition Support Practice manual 2nd edition 2005 p301
Phases of NS in critically Ill Infants5
Special Considerations in Premature & Sick Infants6
Nutritional Issues In NICU7
ParenteralNutrition8
Peripheral Route of Nutrition9
Peripheral Solutions ¨C Osmolarity Calculations10
Routes of Administration - Central11
Central Access OptionsHICKMAN CATHETERPORTGROSHONGPICC LINE12
Central Solutions13
Fluids14
Fluids15Radiant warmers
 Phototherapy
 RDS
 Fever
 Diuretics
 GI losses
Glycosuria
 Heat shields
 Blankets
 Double-walled incubators
 High humidity
 Fluid overload
 Heart failureIncreased RequirementsDecreased Requirements
Fluids16
Parenteral Nutrition17A.S.P.E.N. Board of Directors and the Clinical Guidelines Task Force. Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. J Parenter Enteral Nutr. 2002;26(1suppl): 1SA¨C138SA.
18Parenteral Nutrition
OUTCOMES OF NUTRITION THERAPY19
Energy Requirements components20
TPN Initiation¡­do not start at goal 21
Pathogenesis of Re-feeding Syndrome22
Pathogenesis of Re-feeding Syndrome23
Hypophosphatemia24
Cardiac dysfunction25
Neuromuscular Dysfunction26
Respiratory  Insufficiency27
Hematologic Effects of Hypophosphatemia28
Hypokalemia29
Hypomagnesemia30
Recommendations to Avoid Re-feeding31
Parenteral Nutrition32
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Parenteral nutritionProtein Requirements34
Parenteral nutrition35
Parenteral Nutrition36
Parenteral NutritionDextrose (3.4Kcalories per Gm)37
Parenteral Nutrition38
39Parenteral Nutrition
40Parenteral Nutrition
Parenteral Nutrition41
essential fatty acid deficiency (EFAD)Deficiency of linoleic and linolenic acidsManifestations (hair loss, delay wound healing, dry scaly skin)EFAD can develop within 72 hours if exogenous fat is not given. EFAD can be prevented with as little as 0.5¨C1 g/kg/d of IV lipid42
43Parenteral Nutrition
Parenteral Nutrition44
Parenteral Nutrition45
Calcium Phosphate SolubilityPrecipitation factor =mEq of Ca++ + mM of PO4 x 100Vol (ml) of TPN before addition 					of Ca & PhosphateIf AA Concentartion > 1.5% the precipitation factor must be < 3If AA concentration >1 % and < 1.5%, the precipitation factor should be < 2For PN solutions < 1% AA concentration, either calcium or phosphorous should be addedParenteral Nutrition46
Parenteral Nutrition47
48Parenteral Nutrition3. Effects of Early Erythropoietin Therapy on the Transfusion Requirements of Preterm Infants Below 1250 Grams Birth Weight A Multicenter, Randomized, Controlled Trial. Pediatrics. 2001;108:934¨C942.
Effects of micronutrient deficiency49
Effects of micronutrient deficiency50
Effects of micronutrient deficiency51
52Parenteral Nutrition
Monitoring53Parenteral Nutrition
Monitoring54Parenteral Nutrition
Parneteral Nutrition55
Parenteral Nutrition56
Parenteral Nutrition57
Parenteral Nutrition58
Parenteral Nutrition59
Parenteral Nutrition60
Cyclic TPN61
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Parenteral Nutrtion63
Cause of OcclusionThrombusCrystalsUrokinaseHCl 0.1NSuccessFailureFailureSuccessHClUrokinaseSuccessSuccessFailureFailureEthanol 70%Ethanol 70%64Management Of Catheter Occlusion
Do¡¯s and Don¡¯tsParenteral Nutrition Solutions65
66Do¡¯s and Don¡¯tsParenteral Nutrition Solutions
Filtration of Parenteral Nutrition Admixtures67
Transitioning to Enteral Feeds68
Enteral NutritionSpecial Considerations in Neonates69
Enteral Nutrition70
Enteral Nutrition71
Necrotizing  Enterocolitis and Enteral Feeding72
Necrotizing  Enterocolitis and Enteral Feeding73
Enteral Formulations74
Enteral Formulations75
76Enteral Formulations
Enteral Formulations77

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Editor's Notes

  • #7: Diuretics case mineral and electrolyte losses.Corticosteroids used to shorten the ventilator support can cause negative nitrogen balance, delayed growth, glucose intolerance, bone demineralization and neurodevelopment impairment.