One-lung high frequency jet ventilation (OHFJV) was compared to one-lung conventional mechanical ventilation (OCMV) in patients undergoing lung surgery. OHFJV resulted in decreased peak inspiratory pressure and end-systolic pressure, increased arterial oxygen pressure and cardiac index, and maintained normal pH and carbon dioxide pressure compared to OCMV. OHFJV also ensured excellent oxygenation of blood and increased venous return and cardiac workload without lung recruitment, allowing for its wider application in lung surgeries where gas exchange and hemodynamics are compromised.