The document discusses the oral route of drug administration. It notes that the oral route is the oldest and simplest route, where drugs are administered through the mouth either as solid or liquid dosage forms. It has advantages of being safe, convenient, painless and economical as sterilization is not required. However, it also has disadvantages like incomplete drug absorption, first-pass metabolism, inability to use in emergencies or for unconscious patients, and potential side effects like nausea from gastric irritation.
3. Route of administration
Systemic Local
Enternal Parentral
Oral
Sublingual
Rectal
Inhalation
Injection
Skin Topical
Intranasal
Ocular drops
5. Oral Route
? It is the oldest and simplest route of
administration
? The drug is administered through
mouth.
? The main advantage of this route is
that the patient is able to self-
administer the drug.
6. Oral Route
? Mechanism of oral route is
complicated.
? Solid dosage forms such as powders,
tablets, capsules, etc. and liquid
dosage forms such as elixirs, syrups,
emulsions, etc. can be given through
oral route.
7. First Pass
Metabolism
? It is the hepatic metabolism of
drug when it is absorbed from
the intestine and then delivered
to the liver via the portal vein
8. Advantages of Oral Route
Safe, convenient
and painless
method therefore
most preferred.
Economical
Sterilization is not
required
No assistance is
required
9. Disadvantages of Oral Route
Sometimes complete drug is not absorbed
First-pass metabolism takes place
Not effective in emergencies
Not preferred for unconscious patients
Unpleasant taste of drug
Causes nausea and vomiting due to gastric mucosa irritation