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This document discusses investigations and approaches for unilateral pelvi-ureteric junction obstruction (UPJO). It notes that pre-operative investigations include renal ultrasound, MAG3 renogram, DTPA, DMSA and sometimes VCUG. Indications for surgery include differential renal function less than 40%, symptoms attributable to UPJO, washout curve over 20 minutes with poor function or symptoms, or severe calyceal dilatation/thinning. For UPJO with less than 10% function, initial nephrostomy or JJ stent placement is considered to assess renal function recovery before deciding on nephrectomy or pyeloplasty. Surgical approaches mentioned include open, laparoscopic and robotic techniques. Post-Read less