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overview about Mucormycosis (Black Fungal Disease).pptx

Abdelrhman Abooda
Abdelrhman Abooda

Mucormycosis Black Fungal Disease

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Mucormycosis (Black Fungal Disease) Hadeer Shawaf Abdelrheem ID: 1190507 Under Supervision of Prof. Dr. Rehab Mahmoud Presented by
Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people who have health problems or take medicines that lower the bodys ability to fight germs and sickness. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air. It can also occur on the skin after a cut, burn, or other type of skin injury.
Ress et al reported an annual incidence rate of 1.7 cases per million people in the united states. Biter et al reported an average annual incidence rate of 0.9 per million people in France. The Rhinocerbral accounting for 30-50% of all cases of Mucormyscosis A Meta analysis of all the zygomycosis cases reported from India, Diwakar et al. describe an overall prevalence of ROC (58%), Cutaneous (14%), Pulmonary (6%), Disseminated(7%), Gastrointestinal (7%) and Isolated renal(7%). Prevalence & incidence of Mucormycosis
Rhinocerebral Mucormycosis- An infection of the sinuses that can extend to the brain is called rhino cerebral (sinus and brain) mucormycosis.. Pulmonary Mucormycosis- The most prevalent form of mucormycosis in those with cancer, as well as those who have undergone organ or stem cell transplants, is pulmonary (lung) mucormycosis. Gastrointestinal Mucormycosis- Young children are more likely to develop gastrointestinal Mucormycosis than adults to develop gastrointestinal mucormycosis. Types Of Mucormycosis
Gastrointestinal Mucormycosis- Young children are more likely to develop gastrointestinal Mucormycosis than adults to develop gastrointestinal mucormycosis. Cutaneous Mucormycosis- After the fungus enters the body through a crack in the skin, cutaneous (skin) mucormycosis develops. It mainly appears at the site of a burn, scrape, cut, surgery, or any other kind of skin trauma. Disseminated Mucormycosis- When the infection spreads to another part of the body through the bloodstream, it is known as disseminated mucormycosis. Types Of Mucormycosis
Mucormycosis-causing species are the filamentous fungi of mucoraceae family of the order mucorales, subphylum Mucormycotina. Mucor Cunninghamella Apophysomyces Absidia Saksenaea, Rhizomucor, and other species. Common Causative Organisms
Mucormycosis is caused by a group of fungi known as Mucormycetes, which are present almost everywhere in the environment. These fungi belong to the Order Mucorales and the most common ones that cause mucormycosis, include Rhizopus and Mucor species. Less common varieties of fungi, such as Rhizomucor, Cunninghamella bertholletiae, Syncephalastrum, Apophysomyces elegans, Saksenaea vasiformis, and Lichtheimia corymbifera, are found in soil and decaying organic matter. Causes Of Mucormycosis
Symptoms and Signs of Mucormycosis
Mucormycosis is caused by a group of fungi known as Mucormycetes, which are present almost everywhere in the environment. These fungi belong to the Order Mucorales and the most common ones that cause mucormycosis, include Rhizopus and Mucor species. Less common varieties of fungi, such as Rhizomucor, Cunninghamella bertholletiae, Syncephalastrum, Apophysomyces elegans, Saksenaea vasiformis, and Lichtheimia corymbifera, are found in soil and decaying organic matter. Causes Of Mucormycosis
Timely diagnosis is paramount in cases of Mucormycosis. DNE CECT (PNS) / MRI (with Gadolinium) For pulmonary disease, a bronchoalveolar lavage (BAL), biopsy, or both may assist in the diagnosis. For cutaneous disease, a skin biopsy for pathology and culture should be obtained. Diagnosis
Liposomal and lipid complex amphotericin B Dose - 5 mg/kg/day and 7.5-10mg/kg/day (CNS) Amphotericin B deoxycholate Dose - 1-1.5 mg/kg/d Isavuconazole Dose 200mg TDS for 2 days followed by 200mg OD Posaconazole Dose 300mg BD for 1 day followed by 300mg OD After 3-6weeks of Amph B 3-6 months of Consolidation therapy Anti Fungal Therapy
Adjunctive Treatments Hyperbaric oxygen therapy Deferasirox Immune augmentation strategies granulocyte macrophage colony-stimulating factor, interferon Adjunctive Treatments
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overview about Mucormycosis (Black Fungal Disease).pptx

  • 1. Mucormycosis (Black Fungal Disease) Hadeer Shawaf Abdelrheem ID: 1190507 Under Supervision of Prof. Dr. Rehab Mahmoud Presented by
  • 2. Mucormycosis (previously called zygomycosis) is a serious but rare fungal infection caused by a group of molds called mucormycetes. These molds live throughout the environment. Mucormycosis mainly affects people who have health problems or take medicines that lower the bodys ability to fight germs and sickness. It most commonly affects the sinuses or the lungs after inhaling fungal spores from the air. It can also occur on the skin after a cut, burn, or other type of skin injury.
  • 3. Ress et al reported an annual incidence rate of 1.7 cases per million people in the united states. Biter et al reported an average annual incidence rate of 0.9 per million people in France. The Rhinocerbral accounting for 30-50% of all cases of Mucormyscosis A Meta analysis of all the zygomycosis cases reported from India, Diwakar et al. describe an overall prevalence of ROC (58%), Cutaneous (14%), Pulmonary (6%), Disseminated(7%), Gastrointestinal (7%) and Isolated renal(7%). Prevalence & incidence of Mucormycosis
  • 4. Rhinocerebral Mucormycosis- An infection of the sinuses that can extend to the brain is called rhino cerebral (sinus and brain) mucormycosis.. Pulmonary Mucormycosis- The most prevalent form of mucormycosis in those with cancer, as well as those who have undergone organ or stem cell transplants, is pulmonary (lung) mucormycosis. Gastrointestinal Mucormycosis- Young children are more likely to develop gastrointestinal Mucormycosis than adults to develop gastrointestinal mucormycosis. Types Of Mucormycosis
  • 5. Gastrointestinal Mucormycosis- Young children are more likely to develop gastrointestinal Mucormycosis than adults to develop gastrointestinal mucormycosis. Cutaneous Mucormycosis- After the fungus enters the body through a crack in the skin, cutaneous (skin) mucormycosis develops. It mainly appears at the site of a burn, scrape, cut, surgery, or any other kind of skin trauma. Disseminated Mucormycosis- When the infection spreads to another part of the body through the bloodstream, it is known as disseminated mucormycosis. Types Of Mucormycosis
  • 6. Mucormycosis-causing species are the filamentous fungi of mucoraceae family of the order mucorales, subphylum Mucormycotina. Mucor Cunninghamella Apophysomyces Absidia Saksenaea, Rhizomucor, and other species. Common Causative Organisms
  • 7. Mucormycosis is caused by a group of fungi known as Mucormycetes, which are present almost everywhere in the environment. These fungi belong to the Order Mucorales and the most common ones that cause mucormycosis, include Rhizopus and Mucor species. Less common varieties of fungi, such as Rhizomucor, Cunninghamella bertholletiae, Syncephalastrum, Apophysomyces elegans, Saksenaea vasiformis, and Lichtheimia corymbifera, are found in soil and decaying organic matter. Causes Of Mucormycosis
  • 8. Symptoms and Signs of Mucormycosis
  • 9. Mucormycosis is caused by a group of fungi known as Mucormycetes, which are present almost everywhere in the environment. These fungi belong to the Order Mucorales and the most common ones that cause mucormycosis, include Rhizopus and Mucor species. Less common varieties of fungi, such as Rhizomucor, Cunninghamella bertholletiae, Syncephalastrum, Apophysomyces elegans, Saksenaea vasiformis, and Lichtheimia corymbifera, are found in soil and decaying organic matter. Causes Of Mucormycosis
  • 10. Timely diagnosis is paramount in cases of Mucormycosis. DNE CECT (PNS) / MRI (with Gadolinium) For pulmonary disease, a bronchoalveolar lavage (BAL), biopsy, or both may assist in the diagnosis. For cutaneous disease, a skin biopsy for pathology and culture should be obtained. Diagnosis
  • 11. Liposomal and lipid complex amphotericin B Dose - 5 mg/kg/day and 7.5-10mg/kg/day (CNS) Amphotericin B deoxycholate Dose - 1-1.5 mg/kg/d Isavuconazole Dose 200mg TDS for 2 days followed by 200mg OD Posaconazole Dose 300mg BD for 1 day followed by 300mg OD After 3-6weeks of Amph B 3-6 months of Consolidation therapy Anti Fungal Therapy
  • 12. Adjunctive Treatments Hyperbaric oxygen therapy Deferasirox Immune augmentation strategies granulocyte macrophage colony-stimulating factor, interferon Adjunctive Treatments
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