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Papillary Thyroid
Cancer
M.A.Khachatryan
The anatomo-histological structure of
Thyroid Gland
Characteristics of Papillary Thyroid
Cancer
 80% of TC
 Common in females
 Peak onset ages 30-50
 Follicular cell genesis
 Well-differentiated
 Minimally invasive
 Lymphogenic spread
Causes/ Risk Factors
 Family history/genetic defect maybe involved
 Radiation
 Men
 Older persons
AACE/AME/ETA Thyroid Nodule Guidelines, Endocr Pract.2010;16(Suppl1
Symptoms and Signs
 Few or no symptoms
 Small lump(nodule)
 Painless during palpation
Exams and Tests
 History
 Physical examination
 US
 FNA
 Thyroid function tests
PTC US Features
 Hypoechogenicity
 Inhomogeneous echo pattern
 Microcalcifications
 Absence of peripheral halo
 Irregular borders, blurred margins
 Often intranodular hypervascularity
 Regional lymphadenopathy
Papillary thyroid cancer
Papillary thyroid cancer
Cytology of PTC; Nuclear inclusion.
Primary treatment
 No prospective clinical trials have clearly
determined the best treatment of patients
with PTC
 Appropiate surgical planning
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
Macroscopic pathology-photograph
Microscopic examination
Adjuvant Therapy
 Thyroid Hormone-suppresive therapy
 Radioiodine Remnant Ablation(131J)
202 ENDOCRINE PRACTICE Vol. 7 No. 3 May/June 2001
M.A.Khachatryan
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Papillary thyroid cancer