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Patents at Mach 2: Technology on the Cutting Edge Drexel Experience in a Biomedical Engineering class Jay Bhatt, Drexel University June 22, 2008 American Society for Engineering Education

Drexel’s Engineering Programs All major engineering disciplines Biomedical engineering, Science, and Health systems Interdisciplinary focus is increasing (Nanotechnology, Biomaterials, Bionanotechnology, Biomechanics, etc.) Undergraduate Research Graduate Research

Case Study - Biomaterials Course Sequence 3 Quarters = 2 Semesters Challenges Interdisciplinary Field Diverse Student Background Lack of appropriate textbooks

Biomaterials courses – Biomaterials I – Fall Term Prof. Papazoglou teaches the three course sequence 60-70 students Biomaterials properties Various types of materials such as polymers, hydrogels, ceramics, and glasses Controlled Drug Release systems

Biomaterials courses – Biomaterials II – Winter Term Patents and Intellectual property Students needed to use what they learned in the Fall term as well as search for patents Cancer nanotechnology as an example Group Projects Blog site for patents

Biomaterials courses – Biomaterials II – Winter Term Student Assignment List and briefly describe 5 patented technologies for controlled drug delivery in cancer chemotherapy (last 7 years) List and briefly describe any patent on drug delivery based on nanotechnology for drug delivery of cancer chemotherapy (last 5). Determine uniqueness of each patent Find research literature using sources learned during the Fall term

Patent searching Using US Patents-Advanced Feature ABST/(Cancer and Drug and Delivery) ABST/(controlled and drug and delivery) and (cancer and chemotherapy) ABST-Abstract field that contains brief summary of patent invention The abstract contains many of the relevant words of a patent United States Patent 7,303,739 Erion, et al. December 4, 2007 Prodrugs for liver specific drug delivery. See handout.

Patent Searching Patent Classification Current U.S. Class:424/9.1 ; 424/1.11; 424/1.65; 424/600; 424/601; 424/9.2; 514/7 Observe U.S. Classes. What is a classification schedule? Patents are classified ( organized ) in the U.S. by a system using a 3 digit class and a 3 digit subclass They describe every similar grouping of patent art. A single invention may be described by multiple classification codes For example, Class:424/9.1 ; 424/1.11; 424/1.65; 424/600; 424/601; 424/9.2; 514/7 See Classification Help and Glossary How does classification help in searching for patents?

Patent Searching using classes and subclasses United States Patent 7,303,739 Prodrugs for liver specific drug delivery. See handout Current U.S. Class:424/9.1 ; 424/1.11; 424/1.65; 424/600; 424/601; 424/9.2; 514/7 From USPTO site, go to Class Numbers Only Page (Path: Patents > Guidance, Tools, and Manuals > Classification US Classes by Number Menu) Class 424 : DRUG, BIO-AFFECTING AND BODY TREATING COMPOSITIONS Subclass 9.1 IN VIVO DIAGNOSIS OR IN VIVO TESTING Clicking on ‘P’ retrieves all patents for class 424 subclass 9.1. Similarly other patents in different classes can be found

Patent Searching European Patent Office – World Patents European Patent Office - Advanced Search ‘ Cancer Drug Delivery’ as a keyword NANOPARTICLES FOR CYTOPLASMIC DRUG DELIVERY TO CANCER CELLS Inventor: RADOSZ MARCIEJ (US); SHEN YOUQING (US); (+1) Applicant: UNIV WYOMING (US); RADOSZ MARCIEJ (US); (+2) EC: A61K9/51 IPC: A61K9/14 ; A61K9/14 Publication info: WO2007001356 - 2007-01-04 Complex drug delivery composition and method for treating cancer Inventor: MINKO TAMARA (US); SINKO PATRICK J (US); (+1) Applicant: EC: A61K47/48H4P ; A61K47/48R IPC: A61K47/48 ; A61K47/48 ; (IPC1-7): A61K38/17 Publication info: US2005043215 - 2005-02-24

Thank You! Jay Bhatt Drexel University [email_address] With special thanks to Dr. Elisabeth Papazoglou, Drexel University

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