際際滷

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VII. Pathophysiology
Modifiable
 Lifestyle
 SMOKING
Non- Modifiable
 Age
Decrease secretionof
HCO3 from the pancreas
Increase secretionof HCL
& pepsinfromthe
pancreasintothe
gastrodoudenal.
Increase concentration/
activityof the acid-pepsin
Decrease interference
withHCL secretionfrom
the pancreasinto
duodenum
Mucosal damaged occurs
Duodenal mucosa cannot withstand
the digestive action of the HCL and
pepsin
Damagedmucosa cannot
secrete enoughmucusto
act as a barrieragainstHCL
Duodenal Ulcer
Decrease resistance of
mucosa
Destruction of blood vessels
Further mucosal erosion Increase acid in duodenum,
Erodes the lesions and
stimulates the exposed nerve
endings.
Bile / pancreatic enzymes
reflux from duodenum
Abdominal pain
Mucosal bleeding

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Pathophysiology

  • 1. VII. Pathophysiology Modifiable Lifestyle SMOKING Non- Modifiable Age Decrease secretionof HCO3 from the pancreas Increase secretionof HCL & pepsinfromthe pancreasintothe gastrodoudenal. Increase concentration/ activityof the acid-pepsin Decrease interference withHCL secretionfrom the pancreasinto duodenum Mucosal damaged occurs Duodenal mucosa cannot withstand the digestive action of the HCL and pepsin Damagedmucosa cannot secrete enoughmucusto act as a barrieragainstHCL
  • 2. Duodenal Ulcer Decrease resistance of mucosa Destruction of blood vessels Further mucosal erosion Increase acid in duodenum, Erodes the lesions and stimulates the exposed nerve endings. Bile / pancreatic enzymes reflux from duodenum Abdominal pain Mucosal bleeding