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PHYSICAL & HEALTH
         HAZARDS

Prepared By:                   Guided By :
Amit $hah                      Mr. Jaimin Patel
                               Assistant Professor
M.Pharm,
2nd sem (QA)

Indubhai Patel College of Pharmacy & Research Centre,Dharmaj.
PHYSICAL HAZARDS
                Flammable   Flammable       Oxidizing      Gases under
Explosives
                   gases      aerosol        gases          pressure

 Ammonium
                 Ammonia      propane         Chlorine        Helium
  Nitrate

    1,2,4-
 Butanetriol      Butane      isobutane                        Argon
  trinitrate                                 Fluorine

  Chlorine        Carbon
   azide         Monoxide     n-butane      Nitric Oxide      Nitrogen


 Urea nitrate    Hydrogen
                              Dimethyl       Nitrogen
                               ether         Dioxide         Hydrogen

    RDX          Isobutan
                             methyl ethyl
                               ether          Oxygen
    HBT          Methane



                                                                         2
Flammable        Flammable        Self reactive     Pyrophoric        Pyrophoric
   liquid           solids         substances         liquid            solids

                                      2-diazo-1-
acetaldehyde       camphor           naphthol-4-       Hydrazine        Alkali metals
                                    sulfochloride


                                                                         Grignard
ethyl chloride     cellulose          Benzene
                                                     Triethylborane      reagents
                    nitrate        sulfohydrazide



  petroleum
    ether         Napthalene              4-          Metalorganics     Raney nickel
                                    nitrosophenol


collodion
                  decaborane
                                                                        Phosphorus


 methyl ethyl
  ether
                  lithium amide



  propylene
    oxide          anhydrous
                 sodium sulfide

                                                                                     3
Substances
Self heating       Oxidising        Oxidizing          Organic
                                                                      corrosive to
substances          liquids          solids           peroxides
                                                                         metal



    Activated        Hydrogen                           Acetone
                                    Permanganates                       sulfuric acid
     carbon          peroxide                           peroxide




                                                      Hexamethylene
  Lithium alkyds                     silver nitrate                      nitric acid
                    Nitric acid                         triperoxide
                                                          diamine



                                      Potassium                         hydrochloric
                                                       Methyl ethyl
                                       chlorate                             acid
                   Sulfuric acid                         ketone
                                                        peroxide
   Phosphorus


                                        Sodium                            sodium
                                       peroxide         benzoyl          hydroxide
                   Sodium nitrite
                                                        peroxide
  Pentaborane

                                                                         potassium
                                    Sodium nitrite
                                                                         hydroxide

  Butyl lythium




                                                                                        4
HEALTH HAZARDS
     Skin             Skin               Eye
   corrosion       irritation         irritation


       Phenol           Sodium          Isopropyl
                     lauryl sulfate      alcohol


    hydrochloric         lauryl         hydrogen
        acid            alcohol         peroxide


      sodium
     hydroxide          sodium
                      tetraborate        vinegar



     acetic acid
                     dimethicone


                                                    5
Serious eye       Respiratory        Skin              Germ cell
 damage            sensitizer      sensitizer         mutagenicity




   Strong Acids      Isocyanates     Formaldehyde         nitrous acid




                                                          Polycyclic
  Strong Bases                         Cadmium             aromatic
                                       Chloride          hydrocarbon




                                       Carbon           Ethylnitrosourea
                                       Disulfide




                                                        2-Acetylaminofluorene
                                    Propylene Oxide




                                                                                6
Target organ
                       Reproductive                       Aspiration
Carcinogenecity                              systemic
                         toxicity                          toxicity
                                              toxicity



   benzo(a)pyrene        Benzyl Chloride       Asbestos    Hydrocarbons




                         BISCHLOROETHYL
   Methylcholantrene                            Phenol       iso octane
                           NITROSOUREA




    2-anthranine        CHLORAMBUCIL            Nickel




      benzidine
                         CHLORAMPHENICOL         HCN




   2-naphthylamine
                                               Chromium


                                                                          7
REFERENCE
?   http://en.wikipedia.org/wiki/Category:Explosive_chemicals
?   http://www.engineeringtoolbox.com/classifications-gases-d_838.html
?   http://www.stonybrook.edu/ehs/occupational/cg.shtml
? http://www.ncsu.edu/ehs/www99/right/handsMan/lab/flam.html
?   http://www.searates.com/reference/imo/4.1/
?   http://ehs.ucsb.edu/units/labsfty/labrsc/lsflamable.htm
?   http://en.wikipedia.org/wiki/Pyrophoricity#Liquids
?   http://www.epa.govt.nz/hazardous-substances/about/what-is-
    hs/Pages/List-of-classifications.aspx#Health
?   http://en.wikipedia.org/wiki/Oxidizing_agent
?   http://www.utexas.edu/safety/ehs/lab/manual/appendix_b.pdf
?   http://www.kimyasallar.cevreorman.gov.tr/docs/projeler/sei-
    CLP/Physchem%20Hazards-Examples.pdf
                                                                         8
?   http://en.wikipedia.org/wiki/Organic_peroxide
? http://www.ehs.psu.edu/hazmat/FlammableSolidsAndDWW_Definitio
  nsAndExamples.pdf
?    http://www.webmd.com/skin-problems-and-
    treatments/acne/irritating-substances-that-may-make-acne-worse
? http://www.reptox.csst.qc.ca/Documents/SIMDUT/GuideAng/Htm/Gu
  ideAng10.htm
?   http://www.radford.edu/fpc/Safety/ChemHyg/chp7.htm
?   http://en.wikipedia.org/wiki/Mutagen
?   http://industrial-airfilters.com/pages/Examples-of-Hazardous-
    Fumes.html
?   http://www.cpchem.com/msds/100000068259_SDS_US_EN.PDF
? http://www.hampshire.edu/envhealthsafety/files/appendix5d.pdf

                                                                     9
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Physical & health hazards

  • 1. PHYSICAL & HEALTH HAZARDS Prepared By: Guided By : Amit $hah Mr. Jaimin Patel Assistant Professor M.Pharm, 2nd sem (QA) Indubhai Patel College of Pharmacy & Research Centre,Dharmaj.
  • 2. PHYSICAL HAZARDS Flammable Flammable Oxidizing Gases under Explosives gases aerosol gases pressure Ammonium Ammonia propane Chlorine Helium Nitrate 1,2,4- Butanetriol Butane isobutane Argon trinitrate Fluorine Chlorine Carbon azide Monoxide n-butane Nitric Oxide Nitrogen Urea nitrate Hydrogen Dimethyl Nitrogen ether Dioxide Hydrogen RDX Isobutan methyl ethyl ether Oxygen HBT Methane 2
  • 3. Flammable Flammable Self reactive Pyrophoric Pyrophoric liquid solids substances liquid solids 2-diazo-1- acetaldehyde camphor naphthol-4- Hydrazine Alkali metals sulfochloride Grignard ethyl chloride cellulose Benzene Triethylborane reagents nitrate sulfohydrazide petroleum ether Napthalene 4- Metalorganics Raney nickel nitrosophenol collodion decaborane Phosphorus methyl ethyl ether lithium amide propylene oxide anhydrous sodium sulfide 3
  • 4. Substances Self heating Oxidising Oxidizing Organic corrosive to substances liquids solids peroxides metal Activated Hydrogen Acetone Permanganates sulfuric acid carbon peroxide peroxide Hexamethylene Lithium alkyds silver nitrate nitric acid Nitric acid triperoxide diamine Potassium hydrochloric Methyl ethyl chlorate acid Sulfuric acid ketone peroxide Phosphorus Sodium sodium peroxide benzoyl hydroxide Sodium nitrite peroxide Pentaborane potassium Sodium nitrite hydroxide Butyl lythium 4
  • 5. HEALTH HAZARDS Skin Skin Eye corrosion irritation irritation Phenol Sodium Isopropyl lauryl sulfate alcohol hydrochloric lauryl hydrogen acid alcohol peroxide sodium hydroxide sodium tetraborate vinegar acetic acid dimethicone 5
  • 6. Serious eye Respiratory Skin Germ cell damage sensitizer sensitizer mutagenicity Strong Acids Isocyanates Formaldehyde nitrous acid Polycyclic Strong Bases Cadmium aromatic Chloride hydrocarbon Carbon Ethylnitrosourea Disulfide 2-Acetylaminofluorene Propylene Oxide 6
  • 7. Target organ Reproductive Aspiration Carcinogenecity systemic toxicity toxicity toxicity benzo(a)pyrene Benzyl Chloride Asbestos Hydrocarbons BISCHLOROETHYL Methylcholantrene Phenol iso octane NITROSOUREA 2-anthranine CHLORAMBUCIL Nickel benzidine CHLORAMPHENICOL HCN 2-naphthylamine Chromium 7
  • 8. REFERENCE ? http://en.wikipedia.org/wiki/Category:Explosive_chemicals ? http://www.engineeringtoolbox.com/classifications-gases-d_838.html ? http://www.stonybrook.edu/ehs/occupational/cg.shtml ? http://www.ncsu.edu/ehs/www99/right/handsMan/lab/flam.html ? http://www.searates.com/reference/imo/4.1/ ? http://ehs.ucsb.edu/units/labsfty/labrsc/lsflamable.htm ? http://en.wikipedia.org/wiki/Pyrophoricity#Liquids ? http://www.epa.govt.nz/hazardous-substances/about/what-is- hs/Pages/List-of-classifications.aspx#Health ? http://en.wikipedia.org/wiki/Oxidizing_agent ? http://www.utexas.edu/safety/ehs/lab/manual/appendix_b.pdf ? http://www.kimyasallar.cevreorman.gov.tr/docs/projeler/sei- CLP/Physchem%20Hazards-Examples.pdf 8
  • 9. ? http://en.wikipedia.org/wiki/Organic_peroxide ? http://www.ehs.psu.edu/hazmat/FlammableSolidsAndDWW_Definitio nsAndExamples.pdf ? http://www.webmd.com/skin-problems-and- treatments/acne/irritating-substances-that-may-make-acne-worse ? http://www.reptox.csst.qc.ca/Documents/SIMDUT/GuideAng/Htm/Gu ideAng10.htm ? http://www.radford.edu/fpc/Safety/ChemHyg/chp7.htm ? http://en.wikipedia.org/wiki/Mutagen ? http://industrial-airfilters.com/pages/Examples-of-Hazardous- Fumes.html ? http://www.cpchem.com/msds/100000068259_SDS_US_EN.PDF ? http://www.hampshire.edu/envhealthsafety/files/appendix5d.pdf 9
  • 10. 10