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PHYSIOLOGY OF
SLEEP
By: RAJNISH KUMAR
CIMS BILASPUR
Definitions
 SLEEP:
A state of loss of consciousness form which a subject can
be aroused by appropriate stimulus.
 COMA:
A state of unconsciousness form which a subject cannot be aroused.
SLEEP STAGE
 According to EEG criteria-
1. NREM(non-rapid eye movement)
Stage 1 NREM
Stage 2 NREM
Stage 3 NREM
Stage 4 NREM
2.REM(rapid eye movement)
Physiology of sleep
Physiology of sleep
STAGE 1 NREM
 NREM (non-rapid eye movement) sleep is
dreamless sleep.
 Occurs at sleep onset or following arousal form another
stage of sleep.
 1 to 7 min in the initial cycle.
 2 to 5% of total sleep.
 Easily interupted
 EEG: Rhythmic alpha wave.
STAGE 2 NREM
 Lasts for 10 to 15 min in initial cycle and lengthens with
each successive cycle.
 45 to 55% of total sleep duration.
 Arousal requires more intense stimulus then stage 1.
 EEG: Sleep spindles.
STAGE 3 NREM
 Lasts only for a few minutes.
 3-8% of total sleep.
 EEG - High voltage, slow wave activity or delta wave
STAGE 4 NREM
 Lasts 20-40 minutes in the first cycle.
 10-15% of total sleep.
 Arousal threshold is highest.
 EEG - high voltage slow wave activity-delta waves.Together
with Stage 3 NREM - Slow Wave Sleep (SWS)
 Now, combined with Stage 3 NREM into single entity-N3
Stage
Physiology of sleep
REM
 Desynchronised (low frequency) brain wave activity.
 "Sawtooth" waveforms. Theta activity and slow alpha
activity also characterise REM sleep.
 1-5 minutes in initial cycle.
 Progressively prolonged as sleep progresses.
 4-5 cycles of these sequential stages
 Each cycle -90-110 mins
 As sleep progresses delta sleep decreases and REM sleep
increases.
 REM in initial cycle is only 5-10 mins but in last cycle can
be as long as 40 mins
 As sleep progresses Stage 2 predominates in NREM sleep
and Stage 3 & 4 sometimes disappear altogether.
Physiology of sleep
THANK YOU
True education means fostering the ability to be interested in
something.

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Physiology of sleep

  • 1. PHYSIOLOGY OF SLEEP By: RAJNISH KUMAR CIMS BILASPUR
  • 2. Definitions SLEEP: A state of loss of consciousness form which a subject can be aroused by appropriate stimulus. COMA: A state of unconsciousness form which a subject cannot be aroused.
  • 3. SLEEP STAGE According to EEG criteria- 1. NREM(non-rapid eye movement) Stage 1 NREM Stage 2 NREM Stage 3 NREM Stage 4 NREM 2.REM(rapid eye movement)
  • 6. STAGE 1 NREM NREM (non-rapid eye movement) sleep is dreamless sleep. Occurs at sleep onset or following arousal form another stage of sleep. 1 to 7 min in the initial cycle. 2 to 5% of total sleep. Easily interupted EEG: Rhythmic alpha wave.
  • 7. STAGE 2 NREM Lasts for 10 to 15 min in initial cycle and lengthens with each successive cycle. 45 to 55% of total sleep duration. Arousal requires more intense stimulus then stage 1. EEG: Sleep spindles.
  • 8. STAGE 3 NREM Lasts only for a few minutes. 3-8% of total sleep. EEG - High voltage, slow wave activity or delta wave
  • 9. STAGE 4 NREM Lasts 20-40 minutes in the first cycle. 10-15% of total sleep. Arousal threshold is highest. EEG - high voltage slow wave activity-delta waves.Together with Stage 3 NREM - Slow Wave Sleep (SWS) Now, combined with Stage 3 NREM into single entity-N3 Stage
  • 11. REM Desynchronised (low frequency) brain wave activity. "Sawtooth" waveforms. Theta activity and slow alpha activity also characterise REM sleep. 1-5 minutes in initial cycle. Progressively prolonged as sleep progresses.
  • 12. 4-5 cycles of these sequential stages Each cycle -90-110 mins As sleep progresses delta sleep decreases and REM sleep increases. REM in initial cycle is only 5-10 mins but in last cycle can be as long as 40 mins As sleep progresses Stage 2 predominates in NREM sleep and Stage 3 & 4 sometimes disappear altogether.
  • 14. THANK YOU True education means fostering the ability to be interested in something.