The document proposes implementing a hub-and-spoke distribution model for a global pharmaceutical company to reduce lead times and improve responsiveness. It analyzes how alternative operating policies and supply chain parameters would impact performance of an Asia Pacific distribution hub. A simulation tool would allow testing different planning parameters and policies, such as inventory levels, minimum order quantities, and safety stock. The hub aims to receive products with at least 10% remaining shelf life above affiliates' minimum to reduce obsolescence risks. Demand restriction for low volume products safety stock is also proposed.