The document summarizes research from the Diabetes Prevention Program (DPP) clinical trial. The trial involved 3,234 participants with prediabetes who were assigned to either a lifestyle intervention group, medication (metformin) group, or placebo group. The lifestyle group aimed to lose 7% of body weight through diet and exercise. The results showed that the risk of developing diabetes decreased by 58% in the lifestyle group and 31% in the metformin group compared to placebo. Follow up studies found the risk reduction from the lifestyle intervention lasted for over 15 years at rates of 27-34%, demonstrating prevention can be long lasting. The document also provides details on eligibility, program structure, discussion topics, recommended foods, and potential barriers for D
3. DPP ORIGINAL RESEARCH
MULTICENTER NIH CLINICAL TRIAL
3,234 PARTICIPANTS WITH PREDIABETES
27 CLINICAL CENTERS IN U.S.
LIFESTYLE
REDUCED CALORIES, LOW-FAT DIET
150 MINUTES OF EXERCISE PER WEEK (30
MINUTES OF WALKING 5 DAYS PER WEEK)
WEIGHT LOSS GOAL = 7% OF BODY WEIGHT
MEDICATION
850 MILLIGRAMS METFORMIN TWICE DAILY
PLACEBO
STUDY RESULTS
LIFESTYLE
RISK FOR DEVELOPING DIABETES DECREASED
BY 58%
METFORMIN
RISK FOR DEVELOPING DIABETES DECREASED
BY 31%
DPP Research Group. New England Journal of Medicine. 346: 393-403, 2002.
4. PREVENTION CAN LAST 15+ YEARS
Intervention Risk Reduction @ 3
Years
Risk Reduction @ 10
Years
Risk Reduction @ 15
years
Lifestyle 58% 34% 27%
Metformin 31% 18% 18%
DPP Research Group. Lancet. 374: 1677-1686, 2009. Lancet Diabetes Endocrinology.
DOI: http://dx.doi.org/10.1016/S2213-8587(15)00291-0, 2015.
5. THE 1 YEAR PROGRAM HELPS MAKE HEALTHY LIFESTYLE CHANGES THAT LAST, HOLD PARTICIPANT
ACCOUNTABLE BY ATTENDING CLASSES, AND GET SUPPORT FORM THE GROUP TO HELP MEET GOALS!
PROGRAM GOALS
WEIGHT LOSS: 5-7% OF STARTING
BODY WEIGHT
INCREASING PHYSICAL ACTIVITY TO
150 MINUTES +
PROGRAM STRUCTURE
1 Year Program: weekly, bi-monthly & monthly
sessions
one hour sessions with make-ups available
self-monitoring of weight, food intake, minutes of
physical activity required
goal/action plan set at each session
The Power of Peer Support: trained lifestyle coach
leverages group process to allow group to problem-
solve and support change
6. ELIGIBLE
NATIONAL DPP
PARTICIPANTS
OVERWEIGHT & OBESE ADULTS:
ADULT AGED 18 YEARS AND OLDER WITH A BMI OF 25 OR GREATER (ASIAN
AMERICANS: 23 OR GREATER)
WITH PREDIABETES AND/OR AT RISK FOR DIABETES:
PREDIABETES DIAGNOSED THROUGH BLOOD TEST
FASTING BLOOD SUGAR, A1C, ORAL GLUCOSE TOLERANCE TEST
OR HISTORY OF GESTATIONAL DIABETES
MEDICARE BENEFICIARIES ALSO NEED BLOOD TEST ABOVE
OR INCREASED RISK BASED ON PREDIABETES RISK QUIZ
FOR THOSE WITHOUT MEDICARE
HTTPS://DOIHAVEPREDIABETES.ORG/PDF/PREDIABETES_RISKTEST_12.11.PDF
7. DISCUSSION TOPICS
(26 CDC SESSIONS)
EATING WELL INCLUDING SHOPPING, COOKING, EATING AWAY FROM
HOME, ETC.
GETTING ACTIVE
COPING WITH TRIGGERS
POSITIVE THINKING
MANAGING STRESS
GETTING SUPPORT
HEART HEALTH
CARBOHYDRATES
BURNMORE CALORIES THANYOU TAKE IN
STAYING MOTIVATED
8. HEALTHY
MEAL
BASED ON MY PLATE IDEA FROM
THE AMERICAN DIABETES
ASSOCIATION.
(MEETS THE DRI NEEDS)
9. HEALTHY DPP DIET FOR PREDIABETES
FOODS TO EMPHASIZE
Vegetables
Fish
Plant-based proteins, such as beans, peas, lentils, tofu, and nuts
Whole grains and whole-grain products
Healthy fats such as olive oil and avocado
Fresh fruit
Spices and herbs
Starchy vegetables (e.g., Peas, winter squash, corn, and sweet
potatoes)
Lean animal proteins, such as skinless poultry and eggs.
Reduced-fat dairy products, such as low-fat cheese and fat-free
cottage cheese and plain yogurt.
Water and other low-calorie, hydrating beveragES SUCH AS
DECAFFEINATED GREEN TEA.
PROS
Lower insulin resistance and blood glucose levels
(a1c).
Lower blood pressure, improving cholesterol levels.
Can aid in weight loss due to:
Weekly weigh in, daily tracking of food, physical acty..
Calorie reduction by swapping low-calorie foods such
as lean proteins and vegetables, and having smaller
portions
Swapping empty calories for high-fiber choices such
as fruit and whole grains.
Suggestions for small changes.
Allowances for special occasions and cravings.
https://www.ncbi.nlm.nih.gov/pubmed/22812594
10. HEALTHY DPP DIET FOR PREDIABETES
FOODS TO LIMIT OR AVOID
PROCESSED MEATS
FRIED FOODS
FATTY RED MEAT AND POULTRY WITH SKIN
SOLID FATS (E.G., LARD AND BUTTER)
REFINED GRAINS (E.G., WHITE BREAD, PASTA, RICE, AND CRACKERS, AND REFINED
CEREALS)
SWEETS (E.G., CANDY, CAKE, ICE CREAM, PIE, PASTRIES, AND COOKIES)
SUGAR-SWEETENED BEVERAGES, (E.G., SOFT DRINKS, ENERGY DRINKS, SPORTS
DRINKS, AND SUGAR-SWEETENED COFFEE AND TEA BEVERAGES)
ALCOHOLIC BEVERAGES AND MIXED DRINKS
SUGAR-SWEETENED FOODS, SUCH AS FLAVORED YOGURT AND OATMEAL, AND
SUGARY CONDIMENTS
DRIED FRUIT AND FRUIT JUICE
Water and other low-calorie, hydrating beveragES SUCH AS
DECAFFEINATED GREEN TEA.
CONS
IS LESS FOCUSED ON COUNTING CALORIES AND
GRAMS OF CARBOHYDRATE, FAT, AND PROTEIN
GRAMS .
IS NOT A PRESCRIPTIVE MEAL PLAN
11. EXPERIENCE ON DIET
Easy to follow
Choose from variety of food
Cant stick to well crafted plan.
Effort to enter data and track
Hard to meet Iron
Easy to met Vit A, C, Calcium, Potassium
High on fiber, low on sodium
Weight lost : 遜 pound (62.5- 62.1)
13. WAYS TO ADDRESS BARRIERS/CHALLENGES
FIND OUT THE MOTIVATION
SMALL STEPS AT A TIME
FRESH. FROZEN, CANNED ALL COUNTS TOWARDS MEETING
DAILY GOAL
MENU PLANNING, GROCERY LIST, STOCKING PANTRY.
LOGGING ON THE DAYS YOU THINK YOU EAT MORE.
Though a diet is easy to follow, for me it was a struggle because of the hectic schedule. . I did not like to track the food because it an extra work and takes time and effort in entering data. However, it helped me to see that most of my micro-nutrients need are not meeting.