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Presentation on Edible vaccine

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M
Md. Ridwan Ahmed

Presentation of Edible Vaccine, Properties of an edible vaccine, how to make an edible vaccine, and etc. An edible vaccine is the best vaccine for developing country because of it very cost effective and very simple to use. But our country has not developed this vaccine yet. So it is our responsibility to develop an edible vaccine to protect our human being form more infectious disease.

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Presentation On Plant Genetic Engineering Practical(BGE3206)
Submitted By ASH1413061M | ASH1413062M ASH1413064M | ASH1413065M BKH1413071F Submitted To Md. Anwar Hossain |Assistant Professor Razia Sultana | Assistant Professor Asma Talukder | Lecturer
Vaccine Vaccine is an antigenic substance prepared from the causative agent of a disease or a synthetic substitute, used to provide immunity against one or several disease. Smallpox vaccine, the first successful vaccine was introduced by Edward Jenner in 1796. Edible Vaccine A vaccine in which an antigenic substance is engineered into an edible part of a plant. The concept of edible vaccine was developed by Arntzen in the 1990s.
Should not be toxic Low levels of side effect Should not contaminate the environment Should not cause problem in individual Technique of vaccination should be simple Should be cheap Should provide long lasting immunity
Recombinant Protein(vaccine) Transgenic plant Protection against Rabies glycoprotein Tomato Rabies virus Foot & mouth virus Arabidopsis Foot & mouth virus Herpes virus B surface antigen Tobacco Herpes simplex virus Cholera toxin B subunit Potato Vibrio cholerae Human cytomegalovirus glycoprotein B Tobacco Human cytomegalovirus
Traditional vaccine Edible vaccine Too expensive to be used on large scale Comparatively less expensive Lack of physical infrastructure makes it impossible to disseminate the vaccine May be easily available Required trained personnel to administer injections Do not require any trained personnel to administer Required elaborate production facilities, purification, sterilization, packaging No purification strategies required Cant directly stimulate the immune system Vaccine when taken orally, can directly stimulate the immune system
Presentation on Edible vaccine
Presentation on Edible vaccine
Presentation on Edible vaccine
Cost effective Easy to administer Easy to store Acceptable to poor developing countries Active both mucosal & systemic immunity Heat stable Do not require cold chain maintenance No fear of contamination Delivery of multiple antigens
Transgenic contamination can occur. Antibiotic resistance marker gene can spread from GM food to pathogenic bacteria. Selection of best plant is difficult. Difficulty in dose maintenance. Consistency of dosage from fruit to fruit, plant to plant & generation to generation is not similar. Stability of vaccine in fruit is not known.
The first trial on humans in 1997 (using the heat labile B- toxin from E. coli) is a milestone on the road to creating inexpensive vaccines that might be particularly useful in immunizing people in developing countries, where high cost and logistical issues, such as transportation and the need for certain vaccines to be refrigerated, can thwart effective vaccination programs. The hope is that edible vaccines could be grown in many of the developing countries where they would actually be used. Whatever may be the current situation, a day is not far off when we will be able to pluck a fruit from the garden, eat it and be protected from diseasesmaking needles needless

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Presentation on Edible vaccine

  • 1. Presentation On Plant Genetic Engineering Practical(BGE3206)
  • 2. Submitted By ASH1413061M | ASH1413062M ASH1413064M | ASH1413065M BKH1413071F Submitted To Md. Anwar Hossain |Assistant Professor Razia Sultana | Assistant Professor Asma Talukder | Lecturer
  • 3. Vaccine Vaccine is an antigenic substance prepared from the causative agent of a disease or a synthetic substitute, used to provide immunity against one or several disease. Smallpox vaccine, the first successful vaccine was introduced by Edward Jenner in 1796. Edible Vaccine A vaccine in which an antigenic substance is engineered into an edible part of a plant. The concept of edible vaccine was developed by Arntzen in the 1990s.
  • 4. Should not be toxic Low levels of side effect Should not contaminate the environment Should not cause problem in individual Technique of vaccination should be simple Should be cheap Should provide long lasting immunity
  • 5. Recombinant Protein(vaccine) Transgenic plant Protection against Rabies glycoprotein Tomato Rabies virus Foot & mouth virus Arabidopsis Foot & mouth virus Herpes virus B surface antigen Tobacco Herpes simplex virus Cholera toxin B subunit Potato Vibrio cholerae Human cytomegalovirus glycoprotein B Tobacco Human cytomegalovirus
  • 6. Traditional vaccine Edible vaccine Too expensive to be used on large scale Comparatively less expensive Lack of physical infrastructure makes it impossible to disseminate the vaccine May be easily available Required trained personnel to administer injections Do not require any trained personnel to administer Required elaborate production facilities, purification, sterilization, packaging No purification strategies required Cant directly stimulate the immune system Vaccine when taken orally, can directly stimulate the immune system
  • 10. Cost effective Easy to administer Easy to store Acceptable to poor developing countries Active both mucosal & systemic immunity Heat stable Do not require cold chain maintenance No fear of contamination Delivery of multiple antigens
  • 11. Transgenic contamination can occur. Antibiotic resistance marker gene can spread from GM food to pathogenic bacteria. Selection of best plant is difficult. Difficulty in dose maintenance. Consistency of dosage from fruit to fruit, plant to plant & generation to generation is not similar. Stability of vaccine in fruit is not known.
  • 12. The first trial on humans in 1997 (using the heat labile B- toxin from E. coli) is a milestone on the road to creating inexpensive vaccines that might be particularly useful in immunizing people in developing countries, where high cost and logistical issues, such as transportation and the need for certain vaccines to be refrigerated, can thwart effective vaccination programs. The hope is that edible vaccines could be grown in many of the developing countries where they would actually be used. Whatever may be the current situation, a day is not far off when we will be able to pluck a fruit from the garden, eat it and be protected from diseasesmaking needles needless