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Psp Richardson

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M
ML Cohen

The document discusses tau pathology findings in progressive supranuclear palsy, including neurofibrillary tangles in tufted astrocytes and oligodendroglies. Specific regions involved are the basal ganglia, subthalamic nucleus, globus pallidus, and substantia nigra. The dentate nucleus shows grumose degeneration. Tau burden and distribution patterns can distinguish progressive supranuclear palsy-parkinsonism from Richardson's syndrome.

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The tau of PSP Neurofibrillary tangles Tufted astrocytes (Oligodendroglial) Coiled bodies
Basal ganglia
Subthalamic nucleus
Globus pallidus
Atrophy of superior colliculus
Superior colliculus
Substantia nigra
Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
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Grade 3
Grade 3
Dentate nucleus: Grumose degeneration
PSP-tau scores Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
Distribution of tau pathology in PSP-tau score >7 Pink = Grade 1 Purple = Grade 2 Red = Grade 3 Brown = Grade 4 Williams DR, Holton JL, Strand C, Pittman A, de Silva R, Lees AJ, Revesz T. Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome. Brain. 2007 Jun;130(Pt 6):1566-76.
Mid-Frontal Hippocampus

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Psp Richardson