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R21 presentation hofseth-5

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Lorne Hofseth
Lorne Hofseth

This document provides information about an R21 Boot Camp being held by the College of Pharmacy to foster research ideas and grant submissions. The Boot Camp will involve two informational sessions in October 2021 to discuss exploratory or developmental R21 grants. It encourages faculty to identify new ideas that could solve an important problem or gap. The Interim Associate Dean for Research will work to pair faculty with mentors and foster collaborations. The goal is to increase the number of grants submitted by providing support and resources to move ideas forward from initial concepts to full proposals.

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College of Pharmacy R21 BOOT CAMP New Ideas?! Great Ideas?! New Direction?! High Risk/ High Reward Is there an important Gap you see and can solve?! Intriguing story (to the layman)?! (when you tell the story to someone, does it fascinate them? If so, try testing a hypothesis!) October 25 & 28, 2021 Monday, Oct 25, 12 noon Thursday, Oct 28, 6 pm, zoom Lorne J. Hofseth, Ph.D. Professor Interim Associate Dean for Research hofseth@cop.sc.edu 803-403-5588
Office of ADR Increase # Grants Goals -Foster Research from small to BIG -Foster Ideas from small to BIG Activities Mission R21 Bootcamp Mentee-Mentor Pairings (as identified and as requested) TEAMWORK COMMON MISSION and GOAL
HOW TO GET FROM?: HERE HERE TO
Interim Associate Dean for Research Aka. GRANT, GRANT, GRANT person Phase I: Assess faculty UofSC COP demographics 75% Professional Track -few NIH grant submissions -untapped ideas -obstacles: great ideas, but how to do it?, time, other commitments (clinical) -mostly new, no experience NIH grants 25% Tenure Track -many NIH grant submissions -many ideas -obstacles: time, other commitments -mostly much experience NIH grants OPPORTUNITY For COLLABORATIONS! Mentee Mentor!
Phase II: Talk to all faculty
Phase III: THIS (R21 seminar)
NIH GRANTS GOLD STANDARD MAJOR AWARD EXPLORATORY (OFTEN PROVIDE PILOT DATA FOR R01 BELOW) SMALL GRANT (SEED GRANT) TRANSITION TO INDEPENDENCE GRANTS
R21 presentation hofseth-5
NIH GRANTS GOLD STANDARD MAJOR AWARD EXPLORATORY (OFTEN PROVIDE PILOT DATA FOR R01 BELOW) SMALL GRANT (SEED GRANT) TRANSITION TO INDEPENDENCE GRANTS
R21 Exploratory or Developmental Grant Feasibility or Pilot Studies Great Ideas!? Significant problem or gap!? Innovative answers!? No pilot data necessary 1 good, scientifically rigorous, and reviewer- intriguing figure IS necessary!
The R21 = Exploratory or Developmental Grant ASK THESE 6 QUESTIONS: QUESTION 1: ANY NEW IDEAS? Have you identified a gap that needs fixing? Do you have an innovative skills, tools, team, or hypothesis for fixing this problem/gap? NO IDEA IS A BAD IDEA!!!
Try to tell a fascinating and engaging story (write it in a scientifically rigorous way) 5 minute elevator pitch to friends, family, and colleagues is a good start Senior faculty will help you!!
R21 presentation hofseth-5
9 of them are on the FDA approved list With increasing production and CONSUMPTION! over the past 40 years WHAT IF I TOLD YOU.?...
RED40 is the most popular! WHAT IF I TOLD YOU.?...
CHILDREN love colors and azo dyes are in our food to attract them!!?? WHAT IF I TOLD YOU.?...
Artificial food colors are !! synthesized from coal tar or petroleum by-products!!?????? WHAT IF I TOLD YOU.?...
RED40 causes DNA damage? WHAT IF I TOLD YOU.?...
WOULDNT YOU WANT TO KNOW MORE? SO WILL A REVIEWER!!
9 COLORS = 9 R21s!!?? ANYONE?? 1 piece of Pilot data for each color?!
SO MUCH OPPORTUNITY FOR COLLABORATIONS!!!!
UNIQUE TOOLS in our TOOL BOX!? E.g. microDemographics (Dr. Love) E.g. bigdata/ unique databases and skills to combine these unique databases (CPOS faculty; Buckhaults/Love= UK biobank) E.g. AI expertise (Drs. Buckhaults, Shtutman, AI institute) E.g. access to clinical sites e.g. pediatrics (Dr. Cox); dentists (Dr. Hastings) E.g. Biosimilars (Dr. Bennett)
SO MUCH OPPORTUNITY FOR COLLABORATION!!!! UNIQUE TOOLS in our TOOL BOX!? E.g. Animal models; in vitro models (DDBS faculty) MANY MORE!!: Do YOU have a unique skill or tool?? E.g. Deer mice (Peromyscus colony, Dr. Kiaris) E.g. Drug synthesis/discovery (Drs. McInnes, Li) E.g. Functional genomics (Drs. Shtutman, Roninson, Broude) Eg. Covid lab (Dignostics genomics lab, Dr. Banister)
The R21 = Exploratory or Developmental Grant ASK THESE 6 QUESTIONS: QUESTION 1: ANY NEW IDEAS? Have you identified a gap that needs fixing? Do you have an innovative skills, tools, team, or hypothesis for fixing this problem/gap? NO IDEA IS A BAD IDEA!!!
QUESTION 2: DO I WANT TO LEAD A PROJECT AS A PI or multi-PI (usually 15% effort)? QUESTION 3: DO I WANT PLAY A ROLE IN A PROJECT AS A CO-I (usually 5% effort)?
QUESTION 4: Does my immediate supervisor support an R21 submission? (if PI, usually 15% effort; Co-I, 5% effort)
QUESTIONS 5 and 6: 5. Do I have time to write the grant? (Remember, PI has a team, including students and/or coordinators and/or postdocs and/or technicians) See next slide 6. If I got the grant, can I carry it out? (feasibility)
HOW DIFFICULT WILL THIS BE FOR ME TO WRITE? LOOMING QUESTIONS: The Office of the ADR WILL DO EVERYTHING EXCEPT (we will do the below together, during this boot camp): -SPECIFIC AIMS PAGE (template will be provided) -RESEARCH PLAN (template will be provided) -REFERENCES (because these are generated once your aims and research plan are finished!) SECTIONS of R21 A. Specific Aims, 1 page B. Research plan, 6 pages C. Literature cited D. Project summary, 30 lines E. Human subjects/Vertebrate animal as applicable F. Resource Sharing Plans G. Facilities and Resources H. Equipment I. Budget justification J. Any Letters of Support K. Authentication of key biological and/or chemical resources. ADR office does all this
LOOMING QUESTIONS: HOW MUCH TIME WILL THIS BE FOR ME TO WRITE? -1 in-person meeting per month -10 12 hrs writing time over next 6 months
THINK ABOUT THESE QUESTIONS OVER THE HOLIDAYS: QUESTION YES NO 1. ANY NEW IDEAS? X 2. DO I WANT TO LEAD A PROJECT AS A PI or multi-PI? X 3. DO I WANT TO PARTICIPATE AS A CO-I ? X 4. Does my immediate supervisor support an R21 submission? X 5. Do I have time to write it, and can I or my team do it? X 6. Can I or my team do it? (Feasibility) X
PHASE IV: Lorne will set up a meeting with all in January, 2022 to discuss answers to above Qs and guage interest
BENEFITS of doing this: HELP ALONG THE WAY COMMON MISSION TEAMWORK WE ARE IN THIS to WIN-IT and DO IT TOGETHER!
PHASE V: BOOT CAMP
February, 2022: 3 HOUR MEETING ELEVATOR PITCH IDENTIFY PROJECTS IDENTIFY TEAMS Mentors, CO-Is and PIs
March, 2022 SPECIFIC AIMS (Work with mentors over the month) April, 2022 Gathering of senior faculty Each team present Aims May, 2022 Research Plan June, 2022 Submit
END
Extra 際際滷s
SPECIFIC AIMS PAGE (1 page max): SPECIFIC AIMS (1 page total; 6 lines per vertical inch) The Problem: What is Known: Gap in Knowledge: The Solution (hopefully only you can answer by your awesome idea): Our long-term goal is xxx. The overall objective of this application, which is the next step toward this long-term goal, is xxx. The scientific premise in support of the proposed research is robust: (1)xxx; (2)xxx; (3)xxx; (4)xxx. Etc. Our overall hypothesis is xxx. We will test our hypothesis with the following Specific Aims: Specific Aim 1: To xxx. The hypothesis tested in Aim 1 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with . Specific Aim 2: To xxx. The hypothesis tested in Aim 2 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with scientific rigor. Specific Aim 3: To xxx. The hypothesis tested in Aim 3 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with scientific rigor. Statement of expected outcomes and impact.
RESEARCH STRATEGY (6 pages max) 3 parts: 1. SIGNIFICANCE -usually about 1 page with clear paragraphs and subtitles -includes the most relevant prior literature and a piece of pilot data that supports the overall scientific premise of the study 2. INNOVATION -usually 5 or so bullet points/ 村 of a page total 3. APPROACH -usually 4-5 pages; pay attention to scientific rigor and a clear, concise approach; have a conceptual framework/figure
YOUR STORY SHOULD BE INTRIGUING, SIMPLE, BUT POINTED FEASIBLE SIGNIFICANT GAP/PROBLEM
PROBLEM: -EACH REVIEWER has their own internal scale -Why an intriguing story is critical
If SIGNIFICANCE and INNOVATION (in approach, tools, hypothesis, idea) are not rated well, then your application with not be rated well i.e. it probably wont get discussed
R21 presentation hofseth-5
R21 presentation hofseth-5
5 MINUTE ELEVATOR PITCH YOUR STORY: ______________________
TITLE: 3 most relevant papers related to the topic original data papers! (i.e. knowledge of prior research):
WHY IS THIS SIGNIFICANT: -(1-2 sentences) WHAT ARE THE GAPS? - - -
WHY IS THIS INNOVATIVE: - - - - -
WHY WILL YOU FIX THIS?: - - - - -
CRITERIA WHAT YOU THINK IT IS (1-9) INITIAL PERCEPTION BY AUDIENCE/MENTORS (1-9) Significance Investigators Innovation Approach (for this exercise, just consider feasibility) Environment RATE YOURSELF AND YOUR INITIAL THOUGHTS ON HOW SIGNIFICANT, INNOVATIVE, AND WHETHER YOU THINK IT IS FEASIBLE. RATE INVESTIGATOR AND ENVIRONMENT TOO

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R21 presentation hofseth-5

  • 1. College of Pharmacy R21 BOOT CAMP New Ideas?! Great Ideas?! New Direction?! High Risk/ High Reward Is there an important Gap you see and can solve?! Intriguing story (to the layman)?! (when you tell the story to someone, does it fascinate them? If so, try testing a hypothesis!) October 25 & 28, 2021 Monday, Oct 25, 12 noon Thursday, Oct 28, 6 pm, zoom Lorne J. Hofseth, Ph.D. Professor Interim Associate Dean for Research hofseth@cop.sc.edu 803-403-5588
  • 2. Office of ADR Increase # Grants Goals -Foster Research from small to BIG -Foster Ideas from small to BIG Activities Mission R21 Bootcamp Mentee-Mentor Pairings (as identified and as requested) TEAMWORK COMMON MISSION and GOAL
  • 3. HOW TO GET FROM?: HERE HERE TO
  • 4. Interim Associate Dean for Research Aka. GRANT, GRANT, GRANT person Phase I: Assess faculty UofSC COP demographics 75% Professional Track -few NIH grant submissions -untapped ideas -obstacles: great ideas, but how to do it?, time, other commitments (clinical) -mostly new, no experience NIH grants 25% Tenure Track -many NIH grant submissions -many ideas -obstacles: time, other commitments -mostly much experience NIH grants OPPORTUNITY For COLLABORATIONS! Mentee Mentor!
  • 5. Phase II: Talk to all faculty
  • 6. Phase III: THIS (R21 seminar)
  • 7. NIH GRANTS GOLD STANDARD MAJOR AWARD EXPLORATORY (OFTEN PROVIDE PILOT DATA FOR R01 BELOW) SMALL GRANT (SEED GRANT) TRANSITION TO INDEPENDENCE GRANTS
  • 9. NIH GRANTS GOLD STANDARD MAJOR AWARD EXPLORATORY (OFTEN PROVIDE PILOT DATA FOR R01 BELOW) SMALL GRANT (SEED GRANT) TRANSITION TO INDEPENDENCE GRANTS
  • 10. R21 Exploratory or Developmental Grant Feasibility or Pilot Studies Great Ideas!? Significant problem or gap!? Innovative answers!? No pilot data necessary 1 good, scientifically rigorous, and reviewer- intriguing figure IS necessary!
  • 11. The R21 = Exploratory or Developmental Grant ASK THESE 6 QUESTIONS: QUESTION 1: ANY NEW IDEAS? Have you identified a gap that needs fixing? Do you have an innovative skills, tools, team, or hypothesis for fixing this problem/gap? NO IDEA IS A BAD IDEA!!!
  • 12. Try to tell a fascinating and engaging story (write it in a scientifically rigorous way) 5 minute elevator pitch to friends, family, and colleagues is a good start Senior faculty will help you!!
  • 14. 9 of them are on the FDA approved list With increasing production and CONSUMPTION! over the past 40 years WHAT IF I TOLD YOU.?...
  • 15. RED40 is the most popular! WHAT IF I TOLD YOU.?...
  • 16. CHILDREN love colors and azo dyes are in our food to attract them!!?? WHAT IF I TOLD YOU.?...
  • 17. Artificial food colors are !! synthesized from coal tar or petroleum by-products!!?????? WHAT IF I TOLD YOU.?...
  • 18. RED40 causes DNA damage? WHAT IF I TOLD YOU.?...
  • 19. WOULDNT YOU WANT TO KNOW MORE? SO WILL A REVIEWER!!
  • 20. 9 COLORS = 9 R21s!!?? ANYONE?? 1 piece of Pilot data for each color?!
  • 21. SO MUCH OPPORTUNITY FOR COLLABORATIONS!!!!
  • 22. UNIQUE TOOLS in our TOOL BOX!? E.g. microDemographics (Dr. Love) E.g. bigdata/ unique databases and skills to combine these unique databases (CPOS faculty; Buckhaults/Love= UK biobank) E.g. AI expertise (Drs. Buckhaults, Shtutman, AI institute) E.g. access to clinical sites e.g. pediatrics (Dr. Cox); dentists (Dr. Hastings) E.g. Biosimilars (Dr. Bennett)
  • 23. SO MUCH OPPORTUNITY FOR COLLABORATION!!!! UNIQUE TOOLS in our TOOL BOX!? E.g. Animal models; in vitro models (DDBS faculty) MANY MORE!!: Do YOU have a unique skill or tool?? E.g. Deer mice (Peromyscus colony, Dr. Kiaris) E.g. Drug synthesis/discovery (Drs. McInnes, Li) E.g. Functional genomics (Drs. Shtutman, Roninson, Broude) Eg. Covid lab (Dignostics genomics lab, Dr. Banister)
  • 24. The R21 = Exploratory or Developmental Grant ASK THESE 6 QUESTIONS: QUESTION 1: ANY NEW IDEAS? Have you identified a gap that needs fixing? Do you have an innovative skills, tools, team, or hypothesis for fixing this problem/gap? NO IDEA IS A BAD IDEA!!!
  • 25. QUESTION 2: DO I WANT TO LEAD A PROJECT AS A PI or multi-PI (usually 15% effort)? QUESTION 3: DO I WANT PLAY A ROLE IN A PROJECT AS A CO-I (usually 5% effort)?
  • 26. QUESTION 4: Does my immediate supervisor support an R21 submission? (if PI, usually 15% effort; Co-I, 5% effort)
  • 27. QUESTIONS 5 and 6: 5. Do I have time to write the grant? (Remember, PI has a team, including students and/or coordinators and/or postdocs and/or technicians) See next slide 6. If I got the grant, can I carry it out? (feasibility)
  • 28. HOW DIFFICULT WILL THIS BE FOR ME TO WRITE? LOOMING QUESTIONS: The Office of the ADR WILL DO EVERYTHING EXCEPT (we will do the below together, during this boot camp): -SPECIFIC AIMS PAGE (template will be provided) -RESEARCH PLAN (template will be provided) -REFERENCES (because these are generated once your aims and research plan are finished!) SECTIONS of R21 A. Specific Aims, 1 page B. Research plan, 6 pages C. Literature cited D. Project summary, 30 lines E. Human subjects/Vertebrate animal as applicable F. Resource Sharing Plans G. Facilities and Resources H. Equipment I. Budget justification J. Any Letters of Support K. Authentication of key biological and/or chemical resources. ADR office does all this
  • 29. LOOMING QUESTIONS: HOW MUCH TIME WILL THIS BE FOR ME TO WRITE? -1 in-person meeting per month -10 12 hrs writing time over next 6 months
  • 30. THINK ABOUT THESE QUESTIONS OVER THE HOLIDAYS: QUESTION YES NO 1. ANY NEW IDEAS? X 2. DO I WANT TO LEAD A PROJECT AS A PI or multi-PI? X 3. DO I WANT TO PARTICIPATE AS A CO-I ? X 4. Does my immediate supervisor support an R21 submission? X 5. Do I have time to write it, and can I or my team do it? X 6. Can I or my team do it? (Feasibility) X
  • 31. PHASE IV: Lorne will set up a meeting with all in January, 2022 to discuss answers to above Qs and guage interest
  • 32. BENEFITS of doing this: HELP ALONG THE WAY COMMON MISSION TEAMWORK WE ARE IN THIS to WIN-IT and DO IT TOGETHER!
  • 34. February, 2022: 3 HOUR MEETING ELEVATOR PITCH IDENTIFY PROJECTS IDENTIFY TEAMS Mentors, CO-Is and PIs
  • 35. March, 2022 SPECIFIC AIMS (Work with mentors over the month) April, 2022 Gathering of senior faculty Each team present Aims May, 2022 Research Plan June, 2022 Submit
  • 36. END
  • 38. SPECIFIC AIMS PAGE (1 page max): SPECIFIC AIMS (1 page total; 6 lines per vertical inch) The Problem: What is Known: Gap in Knowledge: The Solution (hopefully only you can answer by your awesome idea): Our long-term goal is xxx. The overall objective of this application, which is the next step toward this long-term goal, is xxx. The scientific premise in support of the proposed research is robust: (1)xxx; (2)xxx; (3)xxx; (4)xxx. Etc. Our overall hypothesis is xxx. We will test our hypothesis with the following Specific Aims: Specific Aim 1: To xxx. The hypothesis tested in Aim 1 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with . Specific Aim 2: To xxx. The hypothesis tested in Aim 2 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with scientific rigor. Specific Aim 3: To xxx. The hypothesis tested in Aim 3 is xxx. We will use/carry out/take advantage of xxxx (state methods in 1 to 2 sentences). Accomplishing this Aim will identify xxxx with scientific rigor. Statement of expected outcomes and impact.
  • 39. RESEARCH STRATEGY (6 pages max) 3 parts: 1. SIGNIFICANCE -usually about 1 page with clear paragraphs and subtitles -includes the most relevant prior literature and a piece of pilot data that supports the overall scientific premise of the study 2. INNOVATION -usually 5 or so bullet points/ 村 of a page total 3. APPROACH -usually 4-5 pages; pay attention to scientific rigor and a clear, concise approach; have a conceptual framework/figure
  • 40. YOUR STORY SHOULD BE INTRIGUING, SIMPLE, BUT POINTED FEASIBLE SIGNIFICANT GAP/PROBLEM
  • 41. PROBLEM: -EACH REVIEWER has their own internal scale -Why an intriguing story is critical
  • 42. If SIGNIFICANCE and INNOVATION (in approach, tools, hypothesis, idea) are not rated well, then your application with not be rated well i.e. it probably wont get discussed
  • 45. 5 MINUTE ELEVATOR PITCH YOUR STORY: ______________________
  • 46. TITLE: 3 most relevant papers related to the topic original data papers! (i.e. knowledge of prior research):
  • 47. WHY IS THIS SIGNIFICANT: -(1-2 sentences) WHAT ARE THE GAPS? - - -
  • 48. WHY IS THIS INNOVATIVE: - - - - -
  • 49. WHY WILL YOU FIX THIS?: - - - - -
  • 50. CRITERIA WHAT YOU THINK IT IS (1-9) INITIAL PERCEPTION BY AUDIENCE/MENTORS (1-9) Significance Investigators Innovation Approach (for this exercise, just consider feasibility) Environment RATE YOURSELF AND YOUR INITIAL THOUGHTS ON HOW SIGNIFICANT, INNOVATIVE, AND WHETHER YOU THINK IT IS FEASIBLE. RATE INVESTIGATOR AND ENVIRONMENT TOO