Rapaport leubering cycle
- 1. RAPAPORT-LEUBERING CYCLE Supplementary pathway to Glycolysis
- 4. This is supplementary pathway to glycolysis. These operative in the erytrocyte of man and other mammals. Rapaport leubering cycle mainly concerned with the synthesis of 2,3-bisphosphoglycerate (2,3-BPG) in RBC.
- 5. 1,3-Bisphosphoglycerate(1,3-BPG) produced In Glycolysis is converted to 2,3-BPG by the Enzyme 2,3-bisphosphoglycerate mutase. 2,3-BPG is hydrolysed to 3-phosphoglycerate phosphatase
- 6. About 15-25% of the glucose Converted to lactate in erythrocytes Goes via 2,3-BPG synthesis.