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DIARREA ASOCIADA A C.
DIFFICILE: RECOMENDACIONES
ACG
MONTERREY, NL. A 7 DE JULIO DE 2017
HR ISSSTE MONTERREY
DPTO. MEDICINA INTERNA
DR. JAIME RENTERIA ORDOEZ
RESIDENTE DE TERCER AO
INTRODUCCION
 Clostridium difficile is a Gram-positive, sporeforming bacterium
usually spread by the fecal-oral route
 Produces toxins A and B that cause disease, ranging from
asymptomatic carriage, to mild diarrhea, to colitis, or
pseudomembranous colitis
 CDI is defined as the acute onset of diarrhea with documented
toxigenic C. difficile or its toxin and no other documented cause for
diarrhea
Am J Gastroenterol 2013; 108:478498
 Rates of CDI have been increasing since 2000, especially in the elderly
with a recent hospitalization or residing in long-term care facility
 Carriage of C. difficile occurs in 5  15 % of healthy adults, but may be
as high as 84.4 % in newborns and healthy infants, and up to 57 % in
residents in LTCF
 The two biggest risk factors are exposure to antibiotics and exposure
to the organism. 15-25% antibiotic-associated diarrhea.
 Others risk factors: gastrointestinal tract surgery, and medications
that reduce gastric acid, including proton-pump inhibitors
Am J Gastroenterol 2013; 108:478498
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
RECOMENDACIONES
Am J Gastroenterol 2013; 108:478498
Am J Gastroenterol 2013; 108:478498
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Am J Gastroenterol 2013; 108:478498
Am J Gastroenterol 2013; 108:478498
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Am J Gastroenterol 2013; 108:478498
Revision colitis pseudomembranosa
Am J Gastroenterol 2013; 108:478498
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Revision colitis pseudomembranosa
Am J Gastroenterol 2013; 108:478498
Am J Gastroenterol 2013; 108:478498
Cochrane Database of Systematic Reviews 2017, Issue 5. Art
Revision colitis pseudomembranosa

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Revision colitis pseudomembranosa

  • 1. DIARREA ASOCIADA A C. DIFFICILE: RECOMENDACIONES ACG MONTERREY, NL. A 7 DE JULIO DE 2017 HR ISSSTE MONTERREY DPTO. MEDICINA INTERNA DR. JAIME RENTERIA ORDOEZ RESIDENTE DE TERCER AO
  • 2. INTRODUCCION Clostridium difficile is a Gram-positive, sporeforming bacterium usually spread by the fecal-oral route Produces toxins A and B that cause disease, ranging from asymptomatic carriage, to mild diarrhea, to colitis, or pseudomembranous colitis CDI is defined as the acute onset of diarrhea with documented toxigenic C. difficile or its toxin and no other documented cause for diarrhea Am J Gastroenterol 2013; 108:478498
  • 3. Rates of CDI have been increasing since 2000, especially in the elderly with a recent hospitalization or residing in long-term care facility Carriage of C. difficile occurs in 5 15 % of healthy adults, but may be as high as 84.4 % in newborns and healthy infants, and up to 57 % in residents in LTCF The two biggest risk factors are exposure to antibiotics and exposure to the organism. 15-25% antibiotic-associated diarrhea. Others risk factors: gastrointestinal tract surgery, and medications that reduce gastric acid, including proton-pump inhibitors Am J Gastroenterol 2013; 108:478498
  • 8. Am J Gastroenterol 2013; 108:478498
  • 13. Am J Gastroenterol 2013; 108:478498
  • 14. Am J Gastroenterol 2013; 108:478498
  • 19. Am J Gastroenterol 2013; 108:478498
  • 21. Am J Gastroenterol 2013; 108:478498
  • 25. Am J Gastroenterol 2013; 108:478498
  • 26. Am J Gastroenterol 2013; 108:478498
  • 27. Cochrane Database of Systematic Reviews 2017, Issue 5. Art