The document discusses Clostridium difficile infection (CDI), providing recommendations from the American College of Gastroenterology. It notes that C. difficile usually spreads via the fecal-oral route and can cause disease ranging from asymptomatic carriage to colitis. The two main risk factors for CDI are antibiotic exposure and exposure to C. difficile. Rates of CDI have been increasing since 2000, especially in elderly patients who have been hospitalized or reside in long-term care facilities.
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Revision colitis pseudomembranosa
1. DIARREA ASOCIADA A C.
DIFFICILE: RECOMENDACIONES
ACG
MONTERREY, NL. A 7 DE JULIO DE 2017
HR ISSSTE MONTERREY
DPTO. MEDICINA INTERNA
DR. JAIME RENTERIA ORDOEZ
RESIDENTE DE TERCER AO
2. INTRODUCCION
Clostridium difficile is a Gram-positive, sporeforming bacterium
usually spread by the fecal-oral route
Produces toxins A and B that cause disease, ranging from
asymptomatic carriage, to mild diarrhea, to colitis, or
pseudomembranous colitis
CDI is defined as the acute onset of diarrhea with documented
toxigenic C. difficile or its toxin and no other documented cause for
diarrhea
Am J Gastroenterol 2013; 108:478498
3. Rates of CDI have been increasing since 2000, especially in the elderly
with a recent hospitalization or residing in long-term care facility
Carriage of C. difficile occurs in 5 15 % of healthy adults, but may be
as high as 84.4 % in newborns and healthy infants, and up to 57 % in
residents in LTCF
The two biggest risk factors are exposure to antibiotics and exposure
to the organism. 15-25% antibiotic-associated diarrhea.
Others risk factors: gastrointestinal tract surgery, and medications
that reduce gastric acid, including proton-pump inhibitors
Am J Gastroenterol 2013; 108:478498