Role of COMT inhibitors as Anti-parkinsonisms
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COMT inhibitors like entacapone and tolcapone are used alongside L-Dopa to treat Parkinson's disease by reducing the breakdown of levodopa and increasing its effectiveness. Entacapone is generally well-tolerated but can cause side effects like diarrhea, vivid dreams, and drowsiness. Tolcapone is similarly effective at inhibiting COMT but carries a higher risk of liver toxicity and its use requires monitoring of liver function. Both drugs have contraindications when used together with other medications due to risk of interactions.
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Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.PEPSICO Presentation to CAGNY Conference Feb 2024
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
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PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.Content Methodology: A Best Practices Report (Webinar)
Content Methodology: A Best Practices Report (Webinar)contently
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This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.How to Prepare For a Successful Job Search for 2024
How to Prepare For a Successful Job Search for 2024Albert Qian
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The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.Social Media Marketing Trends 2024 // The Global Indie Insights
Social Media Marketing Trends 2024 // The Global Indie InsightsKurio // The Social Media Age(ncy)
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The 2024 social media marketing trends report highlights significant shifts influenced by generative AI, including the emergence of personalized content, the rise of virtual influencers, and a stronger focus on user-generated content. Insights were gathered from 33 experts across 23 leading independent agencies, providing a perspective that emphasizes creativity and authenticity in marketing strategies. Key trends also include the blending of B2B and B2C approaches, reflecting changes in consumer behavior and the evolving landscape of social media engagement.Trends In Paid Search: Navigating The Digital Landscape In 2024
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
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The document discusses trends in paid search for 2024, highlighting changes in user behavior, the implications for financial services, and privacy challenges. It emphasizes the importance of adapting search strategies, utilizing AI-driven tools like performance max and smart bidding, and leveraging first-party data for better marketing efficacy. Key takeaways include holistic SEO and SEM approaches, monitoring shifting user intents, and the need for continuous performance evaluation.5 Public speaking tips from TED - Visualized summary
5 Public speaking tips from TED - Visualized summarySpeakerHub
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The document outlines five public speaking tips from Chris Anderson, TED Talks curator, emphasizing the importance of eye contact, vulnerability, humor, humility, and storytelling. These skills are presented as essential for engaging audiences effectively and are increasingly valuable in today's economy. The article posits that mastering these techniques can enhance speakers' ability to communicate ideas powerfully.ChatGPT and the Future of Work - Clark Boyd
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
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The document provides an overview of generative AI, particularly focusing on ChatGPT and its implications for business and the job market. It discusses the rapid growth of generative AI, its applications in marketing, and the skills needed for the AI era while addressing potential job displacement and the need for adaptation. The agenda includes a Q&A session and emphasizes rethinking work in collaboration with AI technology.Getting into the tech field. what next
Getting into the tech field. what next Tessa Mero
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The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.Google's Just Not That Into You: Understanding Core Updates & Search Intent
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
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1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.How to have difficult conversations
How to have difficult conversations Rajiv Jayarajah, MAppComm, ACC
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The document provides essential tips on how to handle difficult conversations in a workplace setting, emphasizing the importance of preparation, environment, and timing. It highlights that many employees dread such conversations, often leading to avoidance and worsening situations. Ultimately, the guide aims to promote positive outcomes while maintaining professional relationships.Introduction to Data Science
Introduction to Data ScienceChristy Abraham Joy
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The document discusses the rise and importance of data science and machine learning, highlighting the growing demand for data scientists and the challenges they face. It explains machine learning concepts such as supervised and unsupervised learning, along with various real-world applications and the necessary steps involved in a machine learning workflow. Additionally, the document emphasizes the iterative process of model improvement and feature engineering used to enhance machine learning outcomes.Artificial Intelligence, Data and Competition SCHREPEL June 2024 OECD dis...
Artificial Intelligence, Data and Competition SCHREPEL June 2024 OECD dis...OECD Directorate for Financial and Enterprise Affairs
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Role of COMT inhibitors as Anti-parkinsonisms
- 5. DDCI
- 7. Entacapone ( Comtan速)200 mg 8/day (DDCI) a great Reduction in the manifestations of parkinsonian syndrome.
- 8. Contraindications : 1) Hypersensitivity. 2) Isocarboxazid (MAOI) Possible hypertensive. 3) sympathomimetics their effect & toxicity.
- 9. Tolcapone ( Tasmar速) 100&200 mg 3/day Structurally and pharmacologically related to Entacapone but. It causes Liver toxicity
- 11. 1-Diarrhea. 2- Vivid dreams and visual hallucinations. 3- Drowsiness. 4- Urine discoloration (orange). 5- Dyskinesias. 6- nausea and vomiting. 7-Tolcapone liver toxicity.