The document outlines a research project to develop a simulation-based framework for holistic assessment of sustainable manufacturing design and management. It discusses limitations of current approaches that assess sustainability dimensions independently. The objective is to integrate sustainability assessment tools and discrete event simulation into a common framework. This would allow analysis of production performance and sustainability impacts, as well as interdependencies between the three sustainability pillars of economic, environmental and social factors. The framework is intended to provide effective sustainability metrics and support decision-making for cost reduction, risk management and consistent reporting.