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DNA sequencing is becoming faster, cheaper, and better. It can tell you about your parentage, ancestry, and risks for genetic diseases, but cannot tell you about your psychology, life history, or learned behaviors. While your genome can be sequenced for $1000, it is important to recognize both its benefits and limitations, as DNA determines your physical traits but does not define who you are as a person. Understanding what genetic information means is more challenging than simply sequencing DNA.
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- 2. you
- 3. DNA sequencing is becoming cheaper, faster, and better
- 4. Moores Law Number of transistors on a chip roughly doubles every two years
- 7. How much can your genome tell you? What cant it tell you?
- 8. The $1000 genome Can tell you Cannot tell you Parentage Psychology Ancestory Life history Risk for Learned behavior mendelian diseases
- 11. Your genome for $1000 Would you want to know?
- 12. DNA sequencing is more than just sequencing DNA
- 14. DNA -> RNA -> Protein (The Central Dogma)
- 15. Cancer is caused by DNA mutations Cancer is a word for thousands of diseases
- 16. Cancer vs. Evolution
- 17. Pharmacogenomics
- 18. Disease is a stage in a dynamic process, not a static point in time
- 20. DNA is what makes you who you are, but you are a lot more than just your DNA
- 21. DNA is extremely useful so take advantage of it. Dont be afraid of it, but recognize its limitations.
- 22. DNA is cheap, fast, and easy to sequence. Understanding what it means is the hard part.
- 23. The Thousand Genomes Project Free for download on Amazon Cloud. All 200 Terabytes of it.
- 25. I think the biggest innovations of the 21st century will be at the intersection of biology and technology. A new era is beginning. Steve Jobs (1955-2011)
- 26. Videos Richard Resnick - TEDxBoston 2011: Welcome to the genomic revolution George Church TEDMED 2010: Personal genomes Greg Lucier TEDMED 2010: When will the genomic medicine revolution finally happen? Barry Schuler TED Taste 2008: Genomics 101 Juan Enriquez TED 2003: On genomics and our future
- 27. Books Lone Frank: My beautiful genome (2011) Kevin Davies: The 1000$ genome (2010) Misha Angrist: Here is a human being (2010) Francis S. Collins: The language of life (2010)
Editor's Notes
- #4: Brief background on evolution of sequencing technologies + price drop: Single molecule approachesSemi conductor chip for sequencing DNA directly on chipNano pore based sequencing approachPull DNA through nano poreNo accuracy or throughput stats yetDNAe (DNA electronics) -real time disposable gene testsBacks Ion torrent and Roche 454 technologySemiconductor technology
- #9: 23AndMe (Personal genomics)Mobile devices, social media,Facebook twitter LinkedIn-->personal genomic dataE.g. warfarinTest carrier diseases (test parents before pregnancy)23andWe discoveries. E.g found protein that appears to be protective125000 individuals in databaseeducational content to promote genetic literacy
- #16: Pharmacogenomics
- #19: Personalized Medicine moves into the clinic, Ralph snydermanDisease is a stage in a dynamic process, not a point in time"Personalized, predictive, prevention"Diseases develop over time as sub clinical disease over timeBaseline risk -> Earliest molecular detection -> earliest clinical detection -> typical current interventionQuantify risk, monitor progression, classify disease
- #22: Personalized Medicine moves into the clinic, Ralph snydermanDisease is a stage in a dynamic process, not a point in time"Personalized, predictive, prevention"Diseases develop over time as sub clinical disease over timeBaseline risk -> Earliest molecular detection -> earliest clinical detection -> typical current interventionQuantify risk, monitor progression, classify disease