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Dongchul Suh

??? ??? ASTRO

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1. ??? ??? ??

2. ??????. -40?-

3. HISTORY VALUE PRODUCT ? Founders ? Story ? Heritage ? Legacy ? Science Board ? ageLOC

4. HISTORY First Office First Products

5. FOUNDERS ??? ?? ??? ?????? ??/ ??? ? ??? ???? ???? ?? ??? ?????? ??? ?? ??? ??? ?????? ?? ???

6. ?? ? ?, ????? ???, ??? ?? ? ? ??? ??? ??? ?? ????? ? ? ???? ?????. 1984? ?? ??? ��?? ??? ?? ???? ??? ?? ? ????�� ??? ??? ?? ???? ??? ??? ???? ?? ???? ???? ?? ??? ? ???? ??? ??? ?? ??? ?? ??? ??? ??? ???. SPOON STORY

7. ???? ??? ????? ?? ??? ?? ??? ???? ??? ??? ?? ??? ????? ?? ?? ????? ??? ???? ?????. ??? ??? ?? ??? ???? ??? ??? ? ?? ?????, ??? ??? ????? ?? ????? ?? ??? ???? ?? ???? ?? ? ??? ???? ???? ???? ?????. SPOON STORY

8. ??? 1984? ? ???? ???? ?? ????? ??? ? ??? ??? ??? 53???? ?? ?? ?? ??? ?? & ???? ???? ???????. SPOON STORY

9. 14?? ?, ?? ????? ?? ??? ?? ? ??? ?. ???? ????? ??? ???? ? ??? ?? ???? ????? ???. HERITAGE

10. 2008? ??1984? ~ 2008? *??? ?? HERITAGE

11. ??????. -3?-

12. LEGACY

13. ??? ?????? ?? ??? ?? ??? ?? ??? ??? ??? ?? ??? II ??? ??? ?? ??? 180�� ?? ?? ?? ??? 1984 1996 2000 2001 2003 2005 *??? ??? ???? ??

14. ??? 180�� ?? ?? ?? ??? II ?? ??? ??? ??? ???? ??? ???? ??????? ??? ?? ??? II ???? ??? ???? ?? ??? 2006 2008 2009 2010 2011 2012 *??? ??? ???? ?? 2017 ???? ????

15. VALUE

16. ?? ? ?? ??? ?????? ?? ?? ??? /?? ?? ??? ?? ?? ?? ??? ?????? ??? ?? ?? ??? ?? ??? ?? ??? ?????? ??? ?? ?? ??? SCIENCE

17. ??? ?? ?? ?? SCIENCE

19. AGE LOCK ?? ???

20. ??? ?? ??? ?? ??? ??? ???? ?? ??? ??? ???? ?? ??? ?? ??? ???? ?????. ??-??? ?? ???

21. ??? ?? SOURCE OF AGING ???? ???? ageLOC SCIENCE ??? COMPETITORS ????? ?? ??

22. ?? ?? Low Expression ?? ?? High Expression ??? ?? ?? Gene Expression Scale ??? ???? Gene Expression Profile ?? YOUNG ?? OLD ???? ???? ???? ageLOC �C ???? ???? ???? DNA Microarray Gene Map DNA???? ??? ??

23. ??? ???? ??

24. ?? ??? ??? ??? ?? ? ? ???? ? Tens of thousands of genes in a single microarray ?? ??? ??? ?? Several dozen gene candidates ???? ??? ?? ??? ?? ??? ?? ???? ??? ?? ?? small set of robust biomarkers for rapid screening of nutrients and phytochemicals ?? ?? Low Expression ?? ?? High Expression

25. ?? ???? ?? Old Gene Expression Looks Like This ?? ???? ?? Young Gene Expression Looks Like This

26. ?? ???? ?? Old Gene Expression Looks Like This ?? ???? ?? Young Gene Expression Looks Like This ???? ?? ??? ?? Old Gene Expression Reset ?? ???? ???? ??? ? ?? ??? Old Gene Now Looks Closer to New One

27. ??? ??? ??? ?? Old Gene Expression ?? ??? ??? ???? Young Gene Expression TARGET ??? ??? ??? ?? ?? Old Gene Expression RESET

28. PRODUCT

30. ???????? 8???? FOR A YOUTHFUL LOOKING YOU

31. 8?????????????? ???????????? ??????????? ?????????????? ????????? ??????????? ???????????????????? &???????????????? ???????????

32. AGELOC? GALVANIC SPA ?????????

33. ???&?? ?????? FOR A YOUTHFUL LOOKING YOU ͯ��w ????

34. 2001 ??? ???????? 3-WAY????? ??????? ????????? ?????? ????????? ????? 2005 2011 2012 ???????? HISTORY

35. *?? ????? ?? ??? ??? 1,000?? ?? MEGA BRAND ?????????

36. AHA?PHA?????? ??? 180��

37. 2000 2006 ???180�� HISTORY

38. ?????? ?????

39. ??????????? ???-??????

40. ????????????? ?????

41. ?????????? ??????

42. PRODUCT CATEGORY AGELOC ???????????????? CORE DAILY SYSTEM ?????????????????? TRU FACE ???????????????? SUNRIGHT ?????????????????

43. PRODUCT CATEGORY FACE MOISTURIZER ??????????????????? SPECIAL CARE ???????????????????? FOR MEN ???????????? AP-24 ??24?????????? BODY CARE ????????????????

44. PRODUCT CATEGORY EPOCH ???????????????????????? HAIR CARE ????????????????????? NU COLOUR ??????????????????

Editor's Notes

#5: ???? ??, ? ??? ?????? ??? ??? ??? ?? ??? ??? ???? ???? ? ??? ?????.
#6: ??? ??, ???? ??, ?? ??????? ??? ???? ??? ?????????.
#10: ?? ? ��??? ?��? ????? 1460?? ??? ?? ??? ?? ?? ? ??. ?? ??? ??? ???? ? ??? ??? ????? ??????. ?? ??? ????? ???? ???? ??? ?? ??? ???? ? ???? ??? ??? ???? ???? ???????. ? ??? ?? ?? ? ??? ?? ??? ???? ?? ???? ??? ?.. ?? ?? ? ��??? ?��???. ????? ??? ???? ��??? ?�� ?
#11: ???? 14?? ???, ?? ?? ? ??? ??? ??? ��??? ?��? ???? ????? ???. ???? ??? ?? ? ??? ???? CI ???? ??? ? ��??? ?��? ?????. ? ???? ????. ????? ??? ???? ��??? ?��? ???.. ? ??? ???? ?? ��??? ??(The Secret of Youth)��? ??????. ?
#13: 1984?, ??? ??? ?? ?? ??? ???? ??? ?? ??. ???, ??? ??, NaPCA ???????, ??? ??? ? ? ???? ? ???? 30?? ??? ?? 2014? ????? ???? ??? ???? ??? ??? ?? ?? ????.
#14: 1984? ??? ??????? ???? 2014???, ???? ??? ??? ?? ? ??? ???????. ???? ?? ???, ? ??? ???? ???? ????? ? ? ????. 1984? ??? ??????? ?? ?, 16?? ???? 1996?, ??? ???? ??????. ???? ??? ?? ??? ?? ??? ????, 2000? ??? ??? 180? ?? ????? ??? 180? ?? ???? ???? ???? ??? ????, 2001? ??? ?? ???? ???? ??? ?? ??? ???? ???? ??? ? ?? ?????? ??? ?????. ?? ?? ??? ??? ??? ??? ?? ???? 180? ?? ???? ???? ???? ?? ???? ??? ?? ??? ??? ??? ? ? ?????.
#15: ??? ??? ??? ??? 2010?, ??? ???? ???? ? ??? ???? ???????? ?? ????. ? ?? ???? ???? ?? ??? ???? ??? ??????, ???? ??? ??? ??? ? ?????. 2011?? 2012?, ??? ? ?? ?????? ??? ??? ???? ??? ?????, ??? ??, ??? ????? ???? ??? From Head to Toe ?? ??? ???? ???. ??? ???? 30??? ?? ??? ????? ???? ??? ?????? ??????.
#17: ???? ???? ???? ?????. ?????? ??? ??? ??? ?? ???? ????? ??? ???? ??? ???? ?? ??, ????? ???? ?????? ????? ???? ????. ??? ???? ? ??????? ????? ??? ?? ? ???? ???? ??? ?? ?? ??? ? ?? ????.
#18: ???? ?? ?? ??? ??? ???, ??? ??? ? ??? ?? ??? ?1??? ???? ????. ?? ??? ?? ??? ????? ??? ?????? ??? ????? ?? ??? ?? ????.
#19: ??? ???? ???? ?? ??? ??? ???? ???? ???, ????.
#20: ??? ??? ��age(???, : ??)�� ? ��lock(?, ?: ???)��? ??? ??? ?????. ????? ???? ???? ???? ?????, ??? ??? ????? ??? ?? ?? ???? ????, ?? ???? ??? ?? ???? ? ??? ???. ????? ?? ???? ??? ???? ?? ??? ??? ?? ???? ???? ?/???? ??? ?? ??? ??? ???? ???? ??? ???? ??? ???? ?? ???? ??? ??? ???? ???? ???? ??????.
#21: ???? ?????? ?? ??? ??? ???? ??? ????? ?? ??? ???? ?? ??? ?? ??? ?? ?? ?? ??? ?????.
#22: ???? ????? ?? ??? ??? ?? ??? ????? ??? ???? ??? ???? ???? ????? ???? ?? ????.
#23: ???? ???? ??? ?? ??? DNA??? ??? ?? DNA??? ??? ??? ? ? ???? ??, ??? ????. ??? ? ? ? ?? DNA???? ?? ???? ?? ??? ?? Porbe? ?? ??? ????????? (hybridization) ??? ???? ?? ? ? ????. ??? ??? DNA??? ???? DNA? Low / High? ??? ???? ???? ??????. ??? ?? ???? ?? ???? ??? ?? ??? ??? ?? ?? ?? ????. [?? ??] Probe (??) : ?????? ????, ??, ?? ?? ????? ???? ??? ?? Nucleotide (??????): DNA ??? ?? ?? ?? Hydridization(???) : ?? ? ??? ???? probe? ?? ?? DNA ???? ??? ?
#24: ???? ????? ??? ?????? ??? ??? ???? ??? ????? ???? ??? ????? ??? ????? ???? ??? ?? ??? ???? ??? ?????.
#25: ??? ??? ?????? ?? ??? ?? ??? ?? ??? ? 20,000~25,000?? ???? ??? ? ?? ?????. ???, ?? ???? ???? ?? ?? ??? ???? ?? ????. . ???, ??? ?? ?? ???? ?? ??? ???? ???? ???? ??????. ??? ?????? ??? ?? ??? ??? ??????. ?? ??? ???? ???? ?? ???? ????, ?? ??? ???? ???? ?? ???? ?????. ? ????, ? ?? ??, ? ?? ???? ?????.
#26: ?? ? ??? ???? ??? ??? ??? ??? ???? ??? ? ?????. ??? ????? ??? ??? ?? ? ????? ???? ?????. ?? ??? ?? ???? ??? ?? ???? ?? ? ??? ??? ??? ??? ??? ???? ??? ???? ??? ??? ??? ???? ?? ? ? ???. ???? ????? 4? ??? ??? ??? ??? ? ? ?? ??? ??? ??? ???? ??? ??? ?????. ??? ?? ??? ??? ??? ?? ??? ?????.
#27: ??? ??? ? ?? ??? ?? ???? ?? ???? ???? ?? ????. In the first two columns, you can see that we have a heat map for young subjects and one for old subjects. ? ?? ???? ??? ?? ?? ??? ? ???? ??? ???? ????. These heat maps represent the genes that changed in expression most robustly with age. ?? ??? ?? ???? ???? ?? ??? ?? ?????. ?? ???? ??? ?? ??? ???? ??? ?? ?? ?? ???? ???? ?????. Now that we know which genes we want to target, old subjects consume various ingredients and then we look at their gene expression over time. ???? ?????, ingredient #4? ?? ???? ??? ?? ???? ???? ??????. As you can see, the ingredient #4, reset gene expression in these old subjects back to a more youthful gene expression profile. ??? ?? ??? ?? ?? ?? ??? ?? ??? ?? ?????. This is one ingredient that we would want to look more closely at.
#28: Heatmap? ????? ??? ageLOC? ??? ??? ??? 3??? ?????? ?????. ?? ??(column1), ??? ??(column2), ????? ??? ??? ??(column3). ? ???? ?? ? ???? ??????? ??? 52?? ???? ?????. Column1? 2? ??? ?? ?? ???? 52?? ?? ?????. Column3??? ????? ??? ??? ??? ?? ? ???? ?? ????, ?? ? ????? ???? ?? ??? ??? column1? ??? ??? ????. .
#29: ??? ????? ??? ???? ??? ???? ??? ???????.
#30: ???? ????? ???? ??? ???? ???? ???, ???? ???????.
#31: ???? ????? ???? ??? ???? ???????. ??? ??? ?? ???? ?? ??? ????? ???? 2010? ?? ?? ?? ?? ???? ???? 470??(??? ??? ?? ??? 17%, ?? ??? ?? ???? ??)? ???? ???? ??? ??? ???? ???? ???? ??????.
#32: ???? ???????? ??? ??? ?? ???? 8?? ????-??, ???, ???, ??, ???, ????, ??, ??-? ????? ??? ? ??? ?????. ???? ??? ???? ?? ?? ?, ????? ???? ????, ?? ??? ???? ???? (??? ???? + ???? ??? ?????)? ?????. ??? ???? ? ?? ??? ??? ???? ????, ???? ????? ???? ? ???? ??? ??? ???? ???? ???????. ???? ????????? ??? ??, ??? ??? ??? ?????? ?????.
#34: ???? ??? ?? ???? ????? ??, ?, ????? ??? ? ?? ???? ??? ???? ????? ?? ???, ??? ??? ? ?? ???? ?? ????? ???? ????. ???? ?? ??? ??? ???? ????? ??? ?????? ???? ???? (From Head to Toe) ?? ??? ?????.
#35: 2001? ? ?? ????? ???? ??? ?? ?, ???? ???? ??? ??? ??????.
#36: 2011? ??? ?? ??? II ???? ??? ??, 2012? ??? ?? ??? ???? ?? ??? ???? ???? ???? ??? ??? ?? ???? ??????. 2013? ???? ??? ?? ?? ???? ??? 1,000?? ??? ???? ???? ?? ???? ??? ??? ????? ??? ?? ???? NO.1 ???? ??? ??? ??? ?? ????.
#37: 2000?? ?? ? ?? ?? ???? ??????? ?? ???? ???? ?? ???? ???? ??? ? ? ??? ? ??? ?????. ? ??? ????? ??? PHA? ?? ?? ???? ??? ?????? AHA ? ? ??????? ??? AHA? ??? ??? ?? ?? ?? ?? ??? ?????.
#38: 180?? ??? ?? ?? ??? ??? ????? ???? ???? ??? ?? ??? 180?? ?? ?? ?????. AHA? ????? ?? ??? 180? ???? ??? ??? ???? ?? ??? ??? ???? ??? ?? ???? ??? ??? ??(PHA)? ???? ????? ???? ????.
#39: ?? ???? ??? ???? ?? ??, ??, ?? ? ??? ??? ???? ????? ?? ?? ?? ??????.
#40: ?? ???? ??? ??? ?? ????? ??, ???-??? ??????. ??? ????? ??? ???? ???? ??? ??? ?? ??? ??? ??? ????.
#41: ??? ?? ???? ??? ??? ???? ?? 3?? ???(???, ??, ?????)? ?? ???? ???? ????? ??????. ???? ??? ?? ???? ??? ???? ???? ???? ???? ??? ?????.
#42: ???, ??, ???????? ???? ??? ?? ? ?? ??? ??? ??? ??? ???? ??? ??? ?? ??????. ??? ?? ? ????? ??? ?? ??? ???? ??? ???? ?????.

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Editor's Notes