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Vara aceasta Escapade Fashion iti aduce cele mai frumoase modele de costume de baie in doua piele http://escapade-fashion.ro 
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El documento habla sobre las ideas y cualidades necesarias para ser un emprendedor exitoso, incluyendo tener entusiasmo, trabajar en equipo, liderazgo, y lograr excelentes ganancias econ¨®micas y sociales a trav¨¦s de la integraci¨®n de personas en el proceso.
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The document discusses porting Flickr to YUI3 and lessons learned about performance. It describes converting code from YUI2 to YUI3, which was mostly straightforward. Two main challenges were making the converted code fast and dealing with long URL strings for combined JavaScript files. Techniques used to improve performance included action queuing, combining modules, and customizing event handling. The document emphasizes measuring performance of important page moments and having a culture focused on optimization.Porting Flickr to YUI3
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Make sure to catch our weekly updates. Updates are done Thursday to Fridays or its a holiday/event weekend.
Thanks again, Readers, Guest Students, and Loyalz/teams.
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AI Overview:
¡°LDMMIA Reiki Yoga refers to a specific program of free online workshops focused on integrating Reiki energy healing techniques with yoga practices. These workshops are led by Leslie M. Moore, also known as LDMMIA, and are designed for all levels, from beginners to those seeking to review their practice. The sessions explore various themes like "Matrix," "Alice in Wonderland," and "Goddess," focusing on self-discovery, inner healing, and shifting personal realities.¡±
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AI Overview:
¡°LDMMIA Reiki Yoga refers to a specific program of free online workshops focused on integrating Reiki energy healing techniques with yoga practices. These workshops are led by Leslie M. Moore, also known as LDMMIA, and are designed for all levels, from beginners to those seeking to review their practice. The sessions explore various themes like "Matrix," "Alice in Wonderland," and "Goddess," focusing on self-discovery, inner healing, and shifting personal realities.¡±
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M.A. Sem - 2 | Presentation
Presentation Season - 2
Paper - 110A: History of English Literature ¨C From 1900 to 2000
Submitted Date: April 1, 2025
Paper Name: History of English Literature ¨C From 1900 to 2000
Topic: Shadows and Light: Exploring Expressionism in ¡®The Cabinet of Dr.?Caligari¡¯ and ¡®Nosferatu: A Symphony of Horror¡¯
[Please copy the link and paste it into any web browser to access the content.]
Video Link: https://youtu.be/pWjHqo6clT4
For a more in-depth discussion of this presentation, please visit the full blog post at the following link:
Please visit this blog to explore additional presentations from this season:
Hashtags:
#GermanExpressionism #SilentHorror #Caligari #Nosferatu #Chiaroscuro #VisualStorytelling #FilmHistory #HorrorCinema #CinematicArt #ExpressionistAesthetics
Keyword Tags:
Expressionism, The Cabinet of Dr. Caligari, Nosferatu, silent film horror, film noir origins, German Expressionist cinema, chiaroscuro techniques, cinematic shadows, psychological horror, visual aestheticsDrug Metabolism advanced medicinal chemistry.pptx
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This document describes about structural metabolism relationship and drug designing and toxicity of drugs in " DRUG METABOLISM"
In Drug Metabolism is the process of converting a drug into product or inert substances after or before reaching at the site of action.
Metabolism plays an important role in elimination of drugs and foreign substance from the body.
The metabolism of any drug is generally characterised by two phases of reaction
1.Metabolic transformation ( biotransformation ) and
2.Conjugation
The Principal site of drug metabolism is the liver, but the kidney, lungs, and GIT also are important metabolic sites.
The enzymatic bio transformations of drugs is known as Drug Metabolism. Because many drugs have structures similar to those of endogenous compounds , drugs may get metabolised by specific enzymes for the related natural substrates as well as by non-specific enzymes.
Reaction type of Phase-I:
1.Oxidation
2.Reduction
3.Hydrolysis
Most drugs are metabolised ,atleast to some extent , by both phases of metabolism.
Example: Metabolism of Aspirin
Acetyl Salicylic acid undergoes hydrolysis to salicylic acid ( metabolic transformation ), which is then conjugated with glycine to form Salicyluric acid ( Conjugation ).
In Phase-II the metabolites formed in Phase-II are converted to more polar and water soluble product by attaching polar and ionisable moiety such as
1.Glucuronic acid
2.Glycine
3.Glutamine
4.Glutathione conjugation
5.Acetylation
6.Methylation
7.Sulfate conjugation
8.Nucleoside and Nucleotide formation
9.Amino Acid Conjugation
10.Fatty Acid and Cholesterol Conjugation
Drug design is the process of creating new drugs by using knowledge of a biological target.
Drug design considers metabolism to optimize pharmaco kinects ( ADME: Absorption , Distribution , Metabolism , Excretion )
Cytochrome CYP450 enzyme in Drug Metabolism is vital in drug design to enhance efficacy , reduce toxicity and improve bioavailability.
Cytochrome P450 enzymes (CYPs) are a superfamily of heme -containing proteins found from bacteria to human.
Cytochrome P-450 activity in various organs like Liver,Lung ,Kidney , Intestine,Placenta
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Toxic Effects of Drug Metabolism
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2.Isoniazid ( TB drug)
3.Chloroform
4.Dapsone
5.Diazepam
6.Salicylate
7.Halothane (Anesthetic)
8.Tamoxifen (Breast Cancer drug )
9.Clozapine(Antipsychotic)
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CURRENT CASE COUNT: 880
? Texas: 729 (+5) (56% of cases are in Gaines County)
? New Mexico: 78 (+4) (83% of cases are from Lea County)
? Oklahoma: 17
? Kansas: 56 (38.89% of the cases are from Gray County)
HOSPITALIZATIONS: 103
? Texas: 94 - This accounts for 13% of all cases in the State.
? New Mexico: 7 ¨C This accounts for 9.47% of all cases in New Mexico.
? Kansas: 2 - This accounts for 3.7% of all cases in Kansas.
DEATHS: 3
? Texas: 2 ¨C This is 0.28% of all cases
? New Mexico: 1 ¨C This is 1.35% of all cases
US NATIONAL CASE COUNT: 1,076 (confirmed and suspected)
INTERNATIONAL SPREAD
? Mexico: 1,753 (+198) 4 fatalities
? Chihuahua, Mexico: 1,657 (+167) cases, 3 fatalities, 9 hospitalizations
? Canada: 2518 (+239) (Includes Ontario¡¯s outbreak, which began November 2024)
? Ontario, Canada: 1,795 (+173) 129 (+10) hospitalizations
? Alberta, Canada: 560 (+55)
Things to keep an eye on:
Mexico: Three children have died this month (all linked to the Chihuahua outbreak):
An 11-month-old and a 7-year-old with underlying conditions
A 1-year-old in Sonora whose family is from Chihuahua
Canada:
Ontario now reports more cases than the entire U.S.
Alberta¡¯s case count continues to climb rapidly and is quickly closing in on 600 cases.
Emerging transmission chains in Manitoba and Saskatchewan underscore the need for vigilant monitoring of under-immunized communities and potential cross-provincial spread.
United States:
North Dakota: Grand Forks County has confirmed its first cases (2), linked to international travel. The state total is 21 since May 2 (including 4 in Cass County and 2 in Williams County), with one hospitalization reported.
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