Online ArticleCh RaoHuman chorionic gonadotropin (hCG) has potential as a therapeutic treatment for painful bladder syndrome/interstitial cystitis (PBS/IC) based on several lines of evidence:
1) Urothelial cells, the cells damaged in PBS/IC, contain hCG/LH receptors and may respond to hCG treatment.
2) Symptoms of PBS/IC seem to improve during pregnancy when hCG levels are high.
3) hCG has pleiotropic effects in other cell types, such as uterine epithelial cells, and may regulate urothelial cells through similar mechanisms.
4) hCG could reduce urothelial cell damage through effects like increasing proliferation, reducing
Reproductive Sciences-2016-Rao-1933719116658705Ch Rao1) The document discusses how it was previously thought that Alzheimer's disease (AD) development in elderly women was due to decreasing estrogen levels after menopause. However, recent evidence suggests it may instead be due to a progressive increase in luteinizing hormone (LH) levels.
2) LH has been shown to promote the amyloidogenic pathway which leads to amyloid beta plaque formation in the hippocampus, a brain region involved in AD. Blocking LH levels has shown therapeutic benefits.
3) The document provides background on AD symptoms and pathology, such as amyloid plaques and neurofibrillary tangles. It also discusses the shift in understanding of LH's actions in the brain through its receptors, such as
Print articleCh Rao1) The document discusses the potential of using human chorionic gonadotropin (hCG) as a therapy for rheumatoid arthritis (RA) and Sjögren's syndrome (SS). HCG contributes to immune tolerance during pregnancy, which alleviates symptoms of these autoimmune diseases.
2) Animal studies show that hCG treatment mimics the benefits of pregnancy for RA and SS, reducing inflammation and immune responses.
3) HCG's immunosuppressive and anti-inflammatory properties suggest it could provide an alternative to current RA and SS therapies, with fewer side effects. Randomized clinical trials of hCG are recommended.
Article in pressCh RaoThis review article discusses evidence that luteinizing hormone (LH) plays a primary role in the development of type 2 endometrial carcinoma in elderly women. It presents several key points of evidence:
1) Endometrial carcinoma cells overexpress LH/hCG receptors compared to normal endometrial cells, and receptor expression increases with tumor stage.
2) Activation of these receptors in endometrial carcinoma cells promotes increased cell proliferation and invasion.
3) LH levels are significantly higher in post-menopausal women who develop endometrial carcinoma compared to those who do not.
4) LH acts through multiple organs like the ovaries, adrenals, adipose tissue, and pancre
Online ArticleCh RaoHuman chorionic gonadotropin (hCG) has potential as a therapeutic treatment for painful bladder syndrome/interstitial cystitis (PBS/IC) based on several lines of evidence:
1) Urothelial cells, the cells damaged in PBS/IC, contain hCG/LH receptors and may respond to hCG treatment.
2) Symptoms of PBS/IC seem to improve during pregnancy when hCG levels are high.
3) hCG has pleiotropic effects in other cell types, such as uterine epithelial cells, and may regulate urothelial cells through similar mechanisms.
4) hCG could reduce urothelial cell damage through effects like increasing proliferation, reducing
Reproductive Sciences-2016-Rao-1933719116658705Ch Rao1) The document discusses how it was previously thought that Alzheimer's disease (AD) development in elderly women was due to decreasing estrogen levels after menopause. However, recent evidence suggests it may instead be due to a progressive increase in luteinizing hormone (LH) levels.
2) LH has been shown to promote the amyloidogenic pathway which leads to amyloid beta plaque formation in the hippocampus, a brain region involved in AD. Blocking LH levels has shown therapeutic benefits.
3) The document provides background on AD symptoms and pathology, such as amyloid plaques and neurofibrillary tangles. It also discusses the shift in understanding of LH's actions in the brain through its receptors, such as
Print articleCh Rao1) The document discusses the potential of using human chorionic gonadotropin (hCG) as a therapy for rheumatoid arthritis (RA) and Sjögren's syndrome (SS). HCG contributes to immune tolerance during pregnancy, which alleviates symptoms of these autoimmune diseases.
2) Animal studies show that hCG treatment mimics the benefits of pregnancy for RA and SS, reducing inflammation and immune responses.
3) HCG's immunosuppressive and anti-inflammatory properties suggest it could provide an alternative to current RA and SS therapies, with fewer side effects. Randomized clinical trials of hCG are recommended.
Article in pressCh RaoThis review article discusses evidence that luteinizing hormone (LH) plays a primary role in the development of type 2 endometrial carcinoma in elderly women. It presents several key points of evidence:
1) Endometrial carcinoma cells overexpress LH/hCG receptors compared to normal endometrial cells, and receptor expression increases with tumor stage.
2) Activation of these receptors in endometrial carcinoma cells promotes increased cell proliferation and invasion.
3) LH levels are significantly higher in post-menopausal women who develop endometrial carcinoma compared to those who do not.
4) LH acts through multiple organs like the ovaries, adrenals, adipose tissue, and pancre
JRMH articleCh RaoHuman chorionic gonadotropin (hCG) is best known as the hormone detected in pregnancy tests, but it has many other roles and functions beyond early pregnancy. While hCG was long thought to only function in supporting the corpus luteum during pregnancy, research over the past 20 years has shown that hCG regulates numerous non-gonadal tissues through its receptors. These regulatory roles include supporting fetal growth and development, safeguarding the fetus from rejection, and allowing delivery when the fetus is mature. The broad regulatory roles of hCG are not entirely unexpected, as many other hormones also have multiple sites of action beyond their main targets. The evolution of these multiple hormone functions is thought to provide functional redundancy and efficiency in response
Ahmed CVahmed katheerThis CV summarizes Ahmed Ali Katheer's personal and professional details. He has over 25 years of experience in safety roles, primarily in Qatar and Egypt, and has worked on numerous pipeline, plant, and industrial projects. His qualifications include a bachelor's degree in arts and various safety certifications. He is currently working as a Scaffolding Safety Inspector on a gas project in Qatar.
OJOG Article on GTNCh RaoThis document summarizes research into why gestational trophoblastic neoplasms overproduce human chorionic gonadotropin (hCG). It finds that these tumors contain higher levels of hCG/LH receptors than normal placenta, preventing hCG from regulating its own biosynthesis through negative feedback. As a result, hCG levels in these tumors can increase unabated. The document also finds that inhibiting hCG production in choriocarcinoma cells leads to increased apoptosis and reduced tumor formation, showing that hCG promotes tumor survival, growth and invasion. Therefore, overproduction of hCG provides gestational trophoblastic neoplasms a strong survival and growth advantage.
Reproductive Sciences-2015-Rao-1484-7Ch RaoThis document discusses potential therapy for Neisseria gonorrhoeae (NG) infections using human chorionic gonadotropin (hCG). NG infects human fallopian tubes through molecular mimicry, binding to hCG/LH receptors on epithelial cells via an hCG-like molecule on its surface. Studies show hCG prevents NG infection of fallopian tube cells in culture by competing for receptor binding. The document proposes testing hCG treatment in clinical trials on infected women since hCG is physiological, inexpensive and nontoxic. HCG could block the initial receptor binding required for NG infection and be a safer alternative or supplement to antibiotics.
cv (2) (1)Shikha BhardwajShikha Pandey is seeking a position that utilizes her knowledge and experience in a challenging environment to maximize benefits for the organization. She has an M.Tech in Food Technology and Engineering from Raja Balwant Singh Engineering Technical Campus and a BE in Bio-Technology. Her areas of interest include research and development, quality control, and production. She has work experience in seed research and development and her technical skills include microbiology, biochemistry techniques, and plant maintenance.
PDF in printCh RaoThis document discusses the potential use of human chorionic gonadotropin (hCG) for treating preterm births. It reviews evidence that hCG inhibits myometrial contractions through various mechanisms, preventing preterm labor. While current drugs can only delay preterm births briefly, studies in mice and limited human trials suggest hCG may more effectively prevent preterm births. The author argues for large randomized controlled clinical trials to further evaluate hCG's safety and effectiveness in reducing preterm births.
2016 INFORMS TLS Urban Transportation SIG SessionsJoseph ChowThis document provides an agenda for a conference on transportation modeling and analytics with multiple sessions covering topics like shared mobility systems, traffic modeling, alternative fuels, data analytics, mobility-on-demand optimization, last mile delivery, travel choice modeling, innovative mobility services, traffic network optimization, and understanding autonomous vehicles. It lists over 60 presentations organized across 26 sessions over 3 days, each with a session chair and presentations covering various transportation modeling research.
Pubahead pdfCh RaoThe document discusses evidence that human chorionic gonadotropin (hCG) protects against breast cancer. Studies in rodent models show that hCG induces mammary gland cell differentiation, decreases proliferation and invasion, and makes cells resistant to carcinogens. HCG levels are highest during early pregnancy in women, and higher levels correlate with lower breast cancer risk. The mechanisms involve hCG activating receptors on breast cells and tissues to promote differentiation and apoptosis while reducing proliferation, invasion and survival. HCG may provide opportunities for breast cancer prevention or treatment by modifying cellular targets of carcinogenesis.