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AmazonTakashi Shiihara
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Amazon entered the Japanese e-book market with its Kindle devices but Japanese customers often have to pay more for e-books compared to customers in other countries like the United States. While Amazon tries to provide low prices, book publishers in Japan maintain control over pricing which leads to higher costs for Japanese readers. The disparity in pricing shows the challenges for global companies operating in different country markets with unique business and cultural norms.kȤȽȄ
kȤȽȄKeiichi Kimura
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This document discusses the pros and cons of fever and antipyretic medications. It summarizes several studies that have found:
1) The use of antipyretics like NSAIDs in patients with sepsis is associated with increased mortality, while fever itself did not increase mortality.
2) In animal models, aspirin use increased mortality in infections by Streptococcus pneumoniae, though no relevant human studies were identified.
3) Overall, whether fever itself causes harm or if antipyretics should be used is still unclear. While all antipyretics lower temperature, medications reported to be dangerous may be best avoided. More research is needed on the effects of antipyretics in human infections.ҽߤĿָ
ҽߤĿָTakahiro Matsumoto
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ձEѧᡡҽ?ѧдk
a presentation on survival in computerization era for young healthcare professionals.Mucolipidosis type4 case report
Mucolipidosis type4 case reportTakashi Shiihara
?
1. This case report describes a Japanese boy with a mild form of Mucolipidosis IV (MLIV), which is typically associated with intellectual disability, corneal opacities, and motor delays.
2. Serial MRI findings in the boy showed thinning of the corpus callosum, white matter volume reduction, and signal abnormalities. Exome sequencing revealed compound heterozygous mutations in the MCOLN1 gene associated with MLIV.
3. Unique features in this case included a relatively mild course, novel mutations, and elevated serum gastrin levels. Serial MRI also showed signs of cerebellar atrophy and iron accumulation over time. Whole exome sequencing was important for correctly diagnosing this rare20151019PBL
20151019PBLShoMyo
?
A 30-year-old man presented with nausea, vomiting, and chest and back pain, and was found to have elevated cardiac enzymes and EKG changes suggestive of ischemia. Coronary angiography showed normal arteries. Cardiac MRI revealed patchy enhancement most consistent with myocarditis.More Related Content
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Mucolipidosis type4 case report
Mucolipidosis type4 case reportTakashi Shiihara
?
1. This case report describes a Japanese boy with a mild form of Mucolipidosis IV (MLIV), which is typically associated with intellectual disability, corneal opacities, and motor delays.
2. Serial MRI findings in the boy showed thinning of the corpus callosum, white matter volume reduction, and signal abnormalities. Exome sequencing revealed compound heterozygous mutations in the MCOLN1 gene associated with MLIV.
3. Unique features in this case included a relatively mild course, novel mutations, and elevated serum gastrin levels. Serial MRI also showed signs of cerebellar atrophy and iron accumulation over time. Whole exome sequencing was important for correctly diagnosing this rare20151019PBL
20151019PBLShoMyo
?
A 30-year-old man presented with nausea, vomiting, and chest and back pain, and was found to have elevated cardiac enzymes and EKG changes suggestive of ischemia. Coronary angiography showed normal arteries. Cardiac MRI revealed patchy enhancement most consistent with myocarditis.