Strep staph dgh 2016
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This document summarizes a study comparing clinical differences between hand phlegmon infections caused by Staphylococcus aureus versus Streptococcus pyogenes. The study retrospectively reviewed records of patients seen at a large tertiary care center for hand phlegmon. It found no significant differences in clinical or laboratory parameters between infections caused by S. aureus versus S. pyogenes. The conclusion is that there are no detectable differences in these infections that would impact treatment decisions.
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Class Examples Mechanism
Proton Pump Inhibitors (PPIs) Omeprazole, Pantoprazole Irreversibly inhibit H+/K+ ATPase pump
H2-Receptor Antagonists Ranitidine, Famotidine Block histamine-mediated gastric acid secretion
2. Mucosal Protective Agents
Class Examples Mechanism
Prostaglandin Analogues Misoprostol Increases mucus & bicarbonate; decreases acid; protects mucosa
Mucosal Coating Agents Sucralfate Forms protective barrier over ulcer site
Bismuth Compounds Bismuth subsalicylate Antimicrobial, mucosal protective, and anti-inflammatory
3. Eradication Therapy (for H. pylori)
Combination of:
PPI + Two Antibiotics (e.g., amoxicillin + clarithromycin OR metronidazole + tetracycline)
Duration: 714 days depending on local guidelines
See BNF regimens above for detailed protocols
4. Cytoprotective/Adjunctive Agents
Class Examples Role in PUD
Somatostatin Analogues Octreotide Used in bleeding ulcers; reduces splanchnic blood flow and gastric secretions
Antacids Magnesium hydroxide, Aluminium hydroxide Neutralize gastric acid; provide symptomatic relief
Non-Pharmacologic Measures
Avoid NSAIDs, smoking, alcohol, and spicy foods
Small, frequent meals in symptomatic patients
Stress reduction
Endoscopic therapy in case of bleeding or perforation
Surgical Indications (rarely needed)
Perforated ulcer
Gastric outlet obstruction
Refractory ulcers not responding to medical therapy
Severe bleeding unresponsive to endoscopic management
Summary
Peptic ulcer disease is primarily driven by H. pylori infection and NSAID use, with duodenal ulcers more common than gastric. Treatment is tailored based on etiology and includes acid suppression, H. pylori eradication, and mucosal protection. Advanced cases may require somatostatin analogues for hemorrhage control or surgery for complications. Prostaglandin analogues like misoprostol are especially valuable in preventing NSAID-induced ulcers.Viddha karma in Ayurveda-Dr Mahesh Kumar.pdf
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Strep staph dgh 2016
- 1. Department of Plastic, Reconstructive and Hand Surgery University Hospital of Lausanne (CHUV), Switzerland STAPHYLOCOCCUS AUREUS VERSUS STREPTOCOCCUS PYOGENES IN COMMUNITY-ACQUIRED HAND PHLEGMONA - ANY CLINICAL DIFFERENCES? M端ller C., Uckay I., Beaulieu J., Erba P., Christen T.
- 2. ANY CLINICAL DIFFERENCES? STREPTOCOCCUS PYOGENES STAPHYLOCOCCUS AUREUS en.wikipedia.org/wiki/Staphylococcus_aureus en.wikipedia.org/wiki/Streptococcus_pyogenes
- 3. 02/01/2018 33 OBJECTIVE musculoskeletal infections: Staphylococcus aureus -> accompanied by abscesses Streptococcus pyogenes -> cellulitis -> rapid spread -> systemic inflammation -> necrotizing fasciitis Tognetti L, Martinelli C, Berti S, et al. Bacterial skin and soft tissue infections: review of the epidemiology, microbiology, aetiopathogenesis and treatment J Eur Acad Dermatol Venereol. 2012;26:931-941.
- 4. 02/01/2018 44 METHODS retrospective study at the Geneva University Hospitals: -> large tertiary care referral center -> records of all patients seen for a phlegmona. We excluded: -> polymicrobial infection; -> health-care-professionals; -> paediatric cases. dsgsdgsdg
- 5. 02/01/2018 55 RESULTS kgjfjhfjkfjkhf+Immune suppression = Diabetes mellitus, dialysis, active cancer 属Group comparisons were performed using the Pearson-2-test, Fisher-exact-test or Wilcoxon-ranksum-test, as appropriate
- 6. 02/01/2018 66 RESULTS kgjfjhfjkfjkhf+Immune suppression = Diabetes mellitus, dialysis, active cancer 属Group comparisons were performed using the Pearson-2-test, Fisher-exact-test or Wilcoxon-ranksum-test, as appropriate
- 7. 7 CONCLUSION This single-center study failed to detect any clinical or laboratory parameters or infection-related consequences that were significantly different in patients with a hand phlegmon caused by S. aureus compared to S. pyogenes. therapeutical consequence: + dgdgddgdg or =
- 8. 02/01/2018 8 Merci Camillo Theo M端ller, MD #phlegmon, #DGH2016, #camillomueller