ChloraPrep provides greater protection against surgical site infections (SSIs) than povidone iodine according to a landmark study:
- It reduced overall infections by 41% and superficial infections by 52% and deep incisional infections by 67% compared to povidone iodine.
- The 2% chlorhexidine concentration is now proven in 39 outcome studies and recommended in 11 evidence-based guidelines to effectively reduce SSIs when used prior to surgery.
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This document presents a fast UHPLC method for quantifying six common parabens (preservatives) in cosmetic products. The UHPLC method using a 1.9 μm column achieved a run time of 3.5 minutes, an over 80% reduction compared to the 19 minute run time using a conventional HPLC column. The UHPLC method also reduced solvent usage by over 90%. The method was shown to be linear, precise, and able to detect parabens at levels within EU and FDA regulations using samples of face lotion and body lotion.
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The document summarizes an analysis of quinine preparations using thin layer chromatography (TLC). Key steps included:
1) Preparing standard and sample solutions of quinine and spotting them on a TLC plate along with standards.
2) Developing the plate in a solvent system to separate components.
3) Analyzing spots under UV light and calculating Rf values.
4) Comparing Rf values of sample spots to standards, finding them to match the 80% quinine standard, confirming the samples contain quinine.
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The Public Accounts Committee report from November 10, 2009 states that while people naturally carry bacteria on their skin, hospitals should not tolerate infections that could have been avoided. Historically infection prevention has focused on healthcare provider asepsis and the environment, but the patient's own skin is now recognized as playing an important role in potential contamination. Every medical procedure that breaches the skin puts patients at risk of contamination from their endogenous skin flora.
Surgical Leave Piece | ChloraPrep UK Infection Prevention & ControlChloraPrep UK
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- SSIs are a serious and costly problem, accounting for 1 in 7 hospital-acquired infections and increasing costs and negative health outcomes.
- ChloraPrep, a 2% chlorhexidine gluconate and 70% isopropyl alcohol antiseptic, was shown in clinical trials to significantly reduce SSIs compared to povidone iodine in various surgeries. It provided reductions of 41-52% in overall and superficial SSIs.
- ChloraPrep has advantages over other antiseptics as it provides broad-spectrum and persistent antimicrobial activity for at least 48 hours, is easy to apply, and is not inactivated in the presence of blood.
This document provides information about anti-fungal susceptibility testing. It discusses various fungi and the available anti-fungal drugs that act on different fungal targets like the cell wall, cell membrane, microtubules, RNA/DNA, and protein synthesis. It covers different testing methods like macrodilution, microdilution, and disk diffusion. It provides details on test medium, inoculum preparation, drug dilutions, and incubation conditions. It also discusses interpretive criteria, quality control strains and ranges, emerging resistance, and the need for susceptibility testing.
This document discusses treatment options for genital warts. It provides details on patient-applied and provider-applied treatment modalities including podofilox, imiquimod, sinecatechins, podophyllin resin, TCA, cryotherapy, and surgical removal. It recommends treatment be guided by patient preference, resources, and provider experience. The most effective treatments aim to relieve symptoms while removing warts, with the goal of inducing wart-free periods.
The document discusses various methods for diagnosing tuberculosis, including microscopy, culture, and rapid diagnostic tests. It provides details on acid-fast staining techniques like Ziehl-Neelsen and fluorescent staining. It describes culture methods using solid and liquid media to isolate Mycobacterium tuberculosis. It also summarizes several rapid culture techniques like BACTEC and MGIT, which can detect TB in 2 weeks compared to 4-6 weeks for conventional methods. Newer rapid tests like CBNAAT can simultaneously detect TB and rifampicin resistance within 2 hours. Overall, the document provides an overview of microbiological methods for TB diagnosis.
This document provides an overview of high performance thin layer chromatography (HPTLC). It begins with definitions and introductions to chromatography and HPTLC. The principles, advantages, differences from TLC, steps involved and applications are summarized. The document also discusses quantitative analysis and identification of various drugs using HPTLC techniques. Key aspects covered include sample preparation, development, detection, scanning, documentation and various mobile phases used for drug analysis.
This document discusses the diagnostic steps for tuberculosis, including history and clinical examination, radiographic features, and bacteriological evaluation. It describes common symptoms and radiographic findings that suggest TB. Sputum smear microscopy and culture are important conventional diagnostic methods discussed in detail. Newer diagnostic tests like Xpert MTB/RIF provide rapid detection of M. tuberculosis and resistance to rifampin directly from sputum samples within 90 minutes. Overall, the document outlines the key diagnostic approaches and tests used to evaluate patients for possible pulmonary tuberculosis.
Intracanal medicaments are used to disinfect the root canal system, reduce microorganisms, and render canal contents inert. Common intracanal medicaments include phenolics, eugenol, parachlorophenol, formocresol, glutaraldehyde, calcium hydroxide, and antibiotics. The ideal intracanal medicament is an effective germicide and fungicide that remains stable, has prolonged antimicrobial effects, and does not interfere with tissue repair or stain tooth structure. However, no single agent fulfills all these criteria.
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Surgical One Page Flyer | ChloraPrep UK Infection Prevention & Control
1. Here’s how you could single-
handedly reduce surgical site
infections by
41%
1
A landmark study published in The New England Journal of Medicine proves
that ChloraPrep provides greater protection against SSIs than povidone iodine1
According to the study, ChloraPrep
(2% Chlorhexidine Gluconate & 70% Isopropyl Alcohol):
reduced overall infections compared with a traditional povidone iodine scrub
and paint method by 41%
reduced superficial infections by 52% and deep incisional infections by 67%
The 2% chlorhexidine concentration is now proven in 39 outcome studies and
recommended in 11 evidence-based guidelines
ChloraPrep. Prep the skin. Protect the patient.
Reference: 1. Darouiche RO et al. N Engl J Med 2010; 362: 18-26.
2. Range of surgical applicators
Licensed, sterile, single use, ANTTâ„¢, latex free applicators available in the UK
Coverage area: 15 cm x 15 cm
clear
3ml
NHS list price per applicator: £0.85 (ex. VAT and delivery)
NHS supply chain order code: MRB306
Coverage area: 25 cm x 30 cm
10.5ml
clear
NHS list price per applicator: £2.92 (ex. VAT and delivery)
NHS supply chain order code: MRB304
Coverage area: 50 cm x 50 cm
26ml
clear
NHS list price per applicator: £6.50 (ex. VAT and delivery)
NHS supply chain order code: MRB305
Coverage area: 15 cm x 15 cm
tinted
3ml
NHS list price per applicator: £0.89 (ex. VAT and delivery)
NHS supply chain order code: MRB494
Coverage area: 25 cm x 30 cm
10.5ml
tinted
NHS list price per applicator: £3.07 (ex. VAT and delivery)
NHS supply chain order code: MRB495
Coverage area: 50 cm x 50 cm
tinted
26ml
NHS list price per applicator: £6.83 (ex. VAT and delivery)
NHS supply chain order code: MRB496
For customer services and all other enquiries:
Please telephone: 0800 0437 546
Email:enquiries@chloraprep.co.uk
or visit: www.chloraprep.co.uk
Prescribing Information skin. Avoid contact with eyes, mucous membranes, middle ear and neural tissue.
ChloraPrep® (PL31760/0002) & ChloraPrep with Tint (PL31760-0001) 2% Should not be used in children under 2 months of age. Solution is flammable. Do not
chlorhexidine gluconate w/v / 70% isopropyl alcohol v/v cutaneous solution. use with ignition sources until dry, do not allow to pool, and remove soaked materials
Indication: Disinfection of skin prior to invasive medical procedures. Dosage & before use. Over-vigorous use on fragile or sensitive skin or repeated use may lead to
administration: ChloraPrep – 0.67ml, 1.5ml, 3ml, 10.5ml, 26ml; ChloraPrep with local skin reactions. At the first sign of local skin reaction, application should be
Tint – 3ml, 10.5ml, 26ml. Volume dependent on invasive procedure being undertaken. stopped. Per applicator costs (ex VAT) ChloraPrep – 0.67ml (SEPP) - 30p; 1.5ml
Applicator squeezed to break ampoule and release antiseptic solution onto sponge. (FREPP) - 55p; 3ml - 85p; 10.5ml - £2.92; 26ml - £6.50. ChloraPrep with Tint – 3ml -
Solution applied by gently pressing sponge against skin and moving back and forth 89p; 10.5ml - £3.07; 26ml - £6.83. Legal category: GSL. Marketing Authorisation
for 30 seconds. The area covered should be allowed to air dry. Side effects, Holder: CareFusion UK 244 Ltd, 43 London Road, Reigate, Surrey RH2 9PW, UK. Date
precautions & contra-indications: Very rarely allergic or skin reactions reported of preparation: July 2010.
with chlorhexidine, isopropyl alcohol and Sunset Yellow. Contra-indicated for patients
with known hypersensitivity to these constituents. For external use only on intact CHL109a Date of preparation: August 2010