This document discusses granulation, which is the process of agglomerating powder particles into larger, multiparticle entities called granules. Granulation improves the flow properties of powders allowing for easier handling in manufacturing processes and improves the uniformity of the final dosage form. There are different granulation techniques including dry granulation which uses roller compaction or slugging, and wet granulation which uses liquid binders or granulating solvents to form granules. The document describes the various steps and considerations in wet and dry granulation processes.
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Tablet Granulation by dr. umesh kumar sharma (2)
1. GRANULATION
Dr. UMESH KUMAR SHARMA,
DEPARTMENT OF PHARMACEUTICS,
MAR DIOSCORUS COLLEGE OF PHARMACY,
THIRUVANANTHAPURAM, KERALABy- Dr. Umesh Kumar Sharma
10. Limitation
Low dose API, poor content uniformity.
High dose API - which is not easily compress, usually
restricted to about 30 %, tablet will be costly and
difficult to swallow.
Direct compression diluent may interact with the API.
Because of the dry nature of direct compression,
static charge develops which effect the uniform
distribution of API in dosage form.
By- Dr. Umesh Kumar Sharma