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GRANULATION
Dr. UMESH KUMAR SHARMA,
DEPARTMENT OF PHARMACEUTICS,
MAR DIOSCORUS COLLEGE OF PHARMACY,
THIRUVANANTHAPURAM, KERALABy- Dr. Umesh Kumar Sharma
CONTENTS:
By- Dr. Umesh Kumar Sharma
Granulation : Definition & Concept
By- Dr. Umesh Kumar Sharma
Why we prepare granules when we have powders.. ?
By- Dr. Umesh Kumar Sharma
Mechanism :
By- Dr. Umesh Kumar Sharma
Granulation Techniques :
Granulation Method:
Direct Compression :
By- Dr. Umesh Kumar Sharma
Direct compression :
By- Dr. Umesh Kumar Sharma
Limitation
Low dose API, poor content uniformity.
High dose API - which is not easily compress, usually
restricted to about 30 %, tablet will be costly and
difficult to swallow.
Direct compression diluent may interact with the API.
Because of the dry nature of direct compression,
static charge develops which effect the uniform
distribution of API in dosage form.
By- Dr. Umesh Kumar Sharma
Dry Granulation :
By- Dr. Umesh Kumar Sharma
Steps Involved in Dry Granulation :
By- Dr. Umesh Kumar Sharma
How we do it ? 
Two method are used:
By- Dr. Umesh Kumar Sharma
Equipments Used:
By- Dr. Umesh Kumar Sharma
Roller Compacter: Chilsonator
By- Dr. Umesh Kumar Sharma
Slugging :
By- Dr. Umesh Kumar Sharma
Tablet Granulation by   dr. umesh kumar sharma (2)
Roller Compacter: Chilsonator
By- Dr. Umesh Kumar Sharma
Wet Granulation:
By- Dr. Umesh Kumar Sharma
Wet Granulation :
By- Dr. Umesh Kumar Sharma
Solvents in Wet Granulation :
By- Dr. Umesh Kumar Sharma
Characteristics of a Granulating Agent:
By- Dr. Umesh Kumar Sharma
The most used granulating solvents
By- Dr. Umesh Kumar Sharma
Granulating Solvents cont..
By- Dr. Umesh Kumar Sharma
Granulating Solvents cont..
By- Dr. Umesh Kumar Sharma
STAGES OF WET GRANULATION:
By- Dr. Umesh Kumar Sharma
Stepwise wet granulation process:
1
2
3
4
5
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
Milling Techniques:
By- Dr. Umesh Kumar Sharma
Drying :
By- Dr. Umesh Kumar Sharma
Characterisation of Granules
By- Dr. Umesh Kumar Sharma
Mass- volume Relationships;
By- Dr. Umesh Kumar Sharma
Characterisation of Granules Cont .
By- Dr. Umesh Kumar Sharma
DENSITY
By- Dr. Umesh Kumar Sharma
POROSITY
By- Dr. Umesh Kumar Sharma
FLOW PROPERTIES
By- Dr. Umesh Kumar Sharma
Flow Properties
ANGLE OF REPOSE
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
By- Dr. Umesh Kumar Sharma
Tablet Granulation by   dr. umesh kumar sharma (2)
Tablet Granulation by   dr. umesh kumar sharma (2)
Tablet Granulation by   dr. umesh kumar sharma (2)
Tablet Granulation by   dr. umesh kumar sharma (2)

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Tablet Granulation by dr. umesh kumar sharma (2)