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- 1. Tanweer A. Khan, Ph.D. Bridgewater, NJ 908-848-3901 takhan74@gmail.com https://www.linkedin.com/in/tanweer-khan-014a5b12?trk=nav_responsive_tab_profile Medicinal Chemist Recognized Expert in Medicinal Chemistry, Experienced in All Key Aspects of Synthetic and Process Chemistry Comprehensive and consistently productive background in research, development, and synthesis of medicinal chemistry for numerous prestigious organizations in the public and private sectors. Research- minded, analytic, and results-driven leadership focus with a collaborative personality. Strong ability to facilitate and negotiate funding for projects, no matter the depth, with proven record of accomplishment of results. CORE COMPETENCIES Medicinal Chemistry Drug Discovery HIT Triage Target Identification Team Management Problem-Solver Compound Identification Resource Management Leadership Chemistry Best Practices Project/Program Management Mentoring/Supervision PROFESSIONAL EXPERIENCE AND ACHIEVEMENTS MRL Kenilworth, NJ 2011 2016 Associate Principal Scientist Led the efforts for coordinating research direction for 4 postdocs, while simultaneously contributing to internal projects. Selected Projects: Heme Dependent Enzyme (Atherosclerosis): Identified and optimized one of the main lead series which demonstrated target engagement in vivo. GPCR (Hypertension and Cardio Metabolic Disease): Developed a tractable SAR, with good PK properties which led to tool compounds. Synthetase (Infectious disease; an anti-bacterial program): Developed a tractable SAR with good PK properties. One of the first compounds to demonstrate wild type cell activity in vitro assay. Protein Hormones (Heart Failure): Helped colleagues in biology in order to establish a suitable assay by developing appropriate tool compounds. Heme Dependent Enzyme (An Anti-Bacterial): Repurposing of the tool compounds and demonstrated in vivo efficacy. Malaria (Anti-parasitic program with neglected and tropical disease): Recognized the potential of repurposing the Merck Small Molec ules for a novel treatment for Malaria. Successfully demonstrated in vivo efficacy. Contributed significantly to the development, submission, and defense of proposals for external funding in order to support collaborative malaria-focused research efforts. DPP4 (Diabetes): Participated in a grand challenge and contributed novel design ideas (sulfoximines) that were selected and resulted in a patent filing (Treating diabetes with dipeptidyl peptidase-IV inhibitors). Schering Plough, NJ 2007 2011 Senior Scientist Led comprehensive research efforts for a multitude of projects.
- 2. Tanweer A. Khan, Ph.D. Page 2 of 3 Selected Projects: Atherosclerosis: Worked on initial triage for a no-go decision. Renin (Hypertension): Developed and then discovered lead compounds based on fragment - based drug design. Demonstrated in vivo efficacy with tool compound. A2A (Parkinsons Disease; Neuroscience): Developed two new series with tractable SAR. New scaffolds were developed as bio isosters of amides, alcohols, and amines. BACE (Alzheimer Disease; Neuroscience): Key participant in a grand challenge and contributed novel design ideas resulting in two patent filings. (Synthesis of S-imino-S- oxoiminothiazine compounds as BACE inhibitors and Synthesis of S-imino S-oxoiminothiazine compounds as BACE inhibitors). ADDITIONAL EXPERIENCE Florida State University, FL 2005 2007 Post-Doctoral Research Fellow Research Advisor: Professor Robert A. Holton Performed studies towards total synthesis of natural product lonomycin A. Designed and developed camphor-based chiral auxiliary for asymmetric Michael addition. University of Strathclyde, UK 2004 2005 Post-Doctoral Research Fellow Research Advisor: Professor John A. Murphy Developed a neutral organic molecule as a powerful electron transfer reagent for radical reactions. Investigated non-classical Wittig reactions. University of Strathclyde, UK 2000 2004 Graduate Assistant Mentor: Professor John A. Murphy Dissertation A novel and clean approach towards the total synthesis of spiropyrrolidinyloxindole and vinca alkaloids. Indian Institute of Technology (IIT), Kanpur, India 1997 2000 Research Assistant Research Advisor: Professor Javed Iqbal Assisted in the design and synthesis of libraries of peptide based, HIV-Protease inhibitors. Developed a route for the synthesis of conformationally constrained peptide. EDUCATION & TRAINING Ph.D., Chemistry, University of Strathclyde, Glasgow, UK Masters of Science, Chemistry, Aligarh M. University, UP, India Bachelors of Science, Chemistry and Zoology, Avadh University, Faizabad, UP, India Chemical Biology-Purpose, Capabilities, and Future Directions Review Therapeutic Modalities Beyond Small Molecules Pharmacology of Drug Discovery Bacteriology 101 Why Bad Bugs Need New Drugs Neuroscience for Medicinal Chemists Leadership Course: Innovate like Edison by Michael J. Gelb Drew University Residential Medicinal Chemistry Course
- 3. Tanweer A. Khan, Ph.D. Page 3 of 3 AWARDS & FELLOWSHIPS Pathfinder Awards, Wellcome Trust, London, UK Award of Excellence for New Target Identifications Award of Excellence for executing Ireland Enterprise Grant Award for Excellence for IP Challenges Award for Excellence for Structure-Based Drug Design Overseas Research Students Award, UK International Research Scholarship, University of Strathclyde, UK Best Officer Merit Awards, Students Union, University of Strathclyde, UK Research Fellowship, Council of Science and Industrial Research, India Research Fellowship, Graduate Aptitude Test in Engineering, India PUBLICATIONS 1. Chambers, Rachel; Khan, Tanweer; Olsen, David B. and Sleebs, Brad, Synthesis of amino heterocycle aspartyl protease inhibitors, Org. Biomol. Chem., 2016, 14, 49704985. 2. Gang Zhou, Robert Aslanian, Gioconda Gallo, Tanweer Khan, et al., Discovery of aminoquinazoline derivatives as human A2A adenosine receptor antagonists, Bioorganic & Medicinal Chemistry Letters, 2016, 26, 7, 1348-1354. 3. McKittrick, Brian A.; and Tanweer Khan et a.al., Iminopyrimidinones: A novel pharmacophore for the development of orally active renin inhibitors, Bioorganic & Medicinal Chemistry Letters, 2015, 25, 1592-1596. 4. V. V. Popik, A. Wright, T. A. Khan and J. A. Murphy, F. Gelat and J-L. Montchamp, Hypophosphorous acid, Electronic Encyclopaedia of Reagents in Organic Synthesis. May 27, 2014, Wiley & Sons, Ltd; DOI: 10.1002/047084289X.rh075.pub3. 5. G. P. McGlacken and T. A. Khan, Formation of carbanions using neutral organic molecules as electron-transfer reagents: A radical concept, Angew. Chem. Int.Ed., 2007, 47, 2. 6. J. A. Murphy, T. A. Khan, S. Zhou, D. W. Thomson, M. Mohan, Highly efficient reduction of unactivated aryl and alkyl iodides by a ground-state neutral organic electron donor, Angew. Chem. Int. Ed., 2005, 44, 1356. 7. J. A. Murphy, R. Tripoli, T. A. Khan and U. W. Mali, Novel phosphorus radical-based routes to horsfiline, Org. Lett., 2005, 7, 3287. 8. J. A. Murphy, A. G. J. Commeureuc, T. N. Snaddon, T. M. McGuire, T. A. Khan, M. L. Dewis and R. Carling, Direct Conversion of N-Methoxy-N-Methylamines to Ketones via a non-Classical Wittig Reaction, Org. Lett., 2005, 7, 1427. 9. S. Lang, M. Corr, N. Muir, T. A. Khan, F. Schonebeck, J. A. Murphy, A. H. Pyne and A. C. Williams, Tetrahedron Lett., 2005, 46, 4027. 10. T. A. Khan, R. Tripoli, J. J. Crawford, C. G. Martin, J. A. Murphy, Diethyl-phosphine oxide (DEPO): High-yielding and facile preparation of indolones in water, Org. Lett., 2003, 5, 2971. 11. A. Wright, T. A. Khan and J. A. Murphy, Electronic Encyclopaedia of Reagents in Organic Synthesis. Article RH075, 2003, Edited by L. Paquette, P. Fuchs, D. Crich and P. Wipf, John Wiley & Sons, Ltd. 12. Manuscript in preparation: Pd nanocubes in the assessment of catalyst shape in a direct acylation/C-H activation reaction, Leticia Pardo, John OConnell, Gillian Collins, Tom OCeallaigh, Tanweer Khan, Justin Holmes and Gerard McGlacken*. 13. Manuscript in preparation: Efficient cross coupling of a difficult substrate class: Access to amino triazoles/tetrazoles, Rafael Cano, Tom OCeallaigh, Tanweer Khan and Gerard McGlacken*.
- 4. Tanweer A. Khan, Ph.D. Page 4 of 3 Patents and patent applications 1. Aminoquinoline compounds as A2A antagonist, Ali, Amjad; Zhou, Gang, Khan Tanweer A., et al., PCT Int. Appl. (2016), WO 2016126570 A1 20160811. 2. Synthesis of S-imino-S-oxoiminothiazine compounds as BACE inhibitors, Khan,Tanweer A.; Scott, Jack D.; Cumming, Jared N. From PCT Int. Appl. (2014), WO 2014150331 A1 20140925. 3. S-imino-s-oxo iminothiadiazine compounds as BACE inhibitors, compositions, and their use, Khan, Tanweer A.; Scott, Jack D.; Cumming, Jared N. PCT Int. Appl. (2014), WO 2014150340 A1 20140925 4. Treating diabetes with dipeptidyl peptidase-IV inhibitors, Biftu, Tesfaye; Khan, Tanweer A. PCT Int. Appl. (2014), WO 2014018355 A1 20140130. 5. Preparation of N3-substituted iminopyrimidinones as renin inhibitors, compositions, and their use. Khan, Tanweer; Josien, Hubert; Mckittrick, Brian; Vaccaro, Henry; Bara, Thomas; Caldwell, John; Heap, Charles R.; Geiss, William B.; Mitra, Sumya; Zych, Andrew J. PCT Int. Appl. (2013), WO 2013142396 A1 20130926. 6. 2 patents applications were already filed and 5 more patents applications are in process and cannot be disclosed at this moment