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Targeting white, brown and perivascular adipose tissue in Atherosclerosis

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Yumna Ali

This document discusses the role of different adipose tissue types in atherosclerosis development. It describes white adipose tissue (WAT) as the main site for energy storage, brown adipose tissue (BAT) for energy combustion, and perivascular adipose tissue (PVAT) providing mechanical support to blood vessels. Hypercholesterolemia and triglyceride-rich lipoproteins contribute to atherosclerosis. The hypothesis is that reducing lipid storage in WAT and increasing lipid combustion in BAT can lower risk of atherosclerosis. Therapeutic strategies aim to enhance lipid storage in WAT, activate BAT thermogenesis, and increase lipolysis in both tissues to reduce triglyceride levels.

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TARGETING WHITE, BROWN AND PERIVASCULAR ADIPOSE TISSUE IN ATHEROSCLEROSIS DEVELOPMENT Andrea D. van Dama,b, Mari谷tte R. Boona,b, Jimmy F.P. Berb辿ea,b, Patrick C.N. Rensena,b, Vanessa van Harmelenb,c 2017, Presented By: Yumna Ali
INTRODUCTION Obesity is a well-established risk factor for atherosclerosis. Adipose tissue comprises various depots including WAT, BAT and thoracic and abdominal perivascular adipose tissue PVAT. Atherosclerosis is promoted by energy-storing adipose depots and attenuated by energy-combusting adipose tissue
HYPOTHESIS To understand the mechanistic link between Adipose tissue and development of atherosclerosis. This Article provides an overview of types and function of adipose tissues, and specific strategies to reduce the risk of Atherosclerosis.
ATHEROSCLEROSIS Hypercholestremia LDL,VLDL, remenent particles in vessel walls.
Triglyceride-rich lipoproteins contribute to Atheroscelerosis
ADIPOSE TISSUE TYPES Adipose tissue is the main site for energy storage Composed of adipocytes The main adipose tissue depots are classi鍖ed as white adipose tissue (WAT), brown adipose tissue (BAT) and perivascular adipose tissue (PVAT).
WHITE ADIPOSE TISSUE
Targeting white, brown and perivascular adipose tissue in Atherosclerosis
BROWN AND BEIGE ADIPOSE TISSUE
Targeting white, brown and perivascular adipose tissue in Atherosclerosis
PERIVASCULAR ADIPOSE TISSUE Provide mechanical support to vessels and regulate vascular tension and torsion. Paracrine effect on the vessel.
Targeting white, brown and perivascular adipose tissue in Atherosclerosis
THERAPEUTIC IMPLICATIONS Triglyceride Lowering Strategies Lipid storage in WAT enhanced by TZD
Lipid Combustion by BAT Activation of B3 adrenergic receptor induce thermogenesis and lipid combustion
INCREASE LIPOLYSIS IN WAT AND BAT Lipolysis in WAT fatty acid release hypertriglyceridemia Lipolysis in BAT combustion of fatty acid lower plasma triglyceride levels
Targeting white, brown and perivascular adipose tissue in Atherosclerosis
CONCLUSION WAT,BAT, PVAT play important role in development of atherosclerosis. To reduce risk of atherosclerosis , the most favourable approach to eliminate TRL is, by increasing combustion of fatty acid in BAT, and reduce lipid storage in WAT.
Prof. Silvia Biocca (uniroma2.it) (research methodology) First Year Physical Activity and Health Promotion batch 2016/2017 ACKNOWLEDGMENT
Targeting white, brown and perivascular adipose tissue in Atherosclerosis

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Targeting white, brown and perivascular adipose tissue in Atherosclerosis

  • 1. TARGETING WHITE, BROWN AND PERIVASCULAR ADIPOSE TISSUE IN ATHEROSCLEROSIS DEVELOPMENT Andrea D. van Dama,b, Mari谷tte R. Boona,b, Jimmy F.P. Berb辿ea,b, Patrick C.N. Rensena,b, Vanessa van Harmelenb,c 2017, Presented By: Yumna Ali
  • 2. INTRODUCTION Obesity is a well-established risk factor for atherosclerosis. Adipose tissue comprises various depots including WAT, BAT and thoracic and abdominal perivascular adipose tissue PVAT. Atherosclerosis is promoted by energy-storing adipose depots and attenuated by energy-combusting adipose tissue
  • 3. HYPOTHESIS To understand the mechanistic link between Adipose tissue and development of atherosclerosis. This Article provides an overview of types and function of adipose tissues, and specific strategies to reduce the risk of Atherosclerosis.
  • 4. ATHEROSCLEROSIS Hypercholestremia LDL,VLDL, remenent particles in vessel walls.
  • 5. Triglyceride-rich lipoproteins contribute to Atheroscelerosis
  • 6. ADIPOSE TISSUE TYPES Adipose tissue is the main site for energy storage Composed of adipocytes The main adipose tissue depots are classi鍖ed as white adipose tissue (WAT), brown adipose tissue (BAT) and perivascular adipose tissue (PVAT).
  • 9. BROWN AND BEIGE ADIPOSE TISSUE
  • 11. PERIVASCULAR ADIPOSE TISSUE Provide mechanical support to vessels and regulate vascular tension and torsion. Paracrine effect on the vessel.
  • 13. THERAPEUTIC IMPLICATIONS Triglyceride Lowering Strategies Lipid storage in WAT enhanced by TZD
  • 14. Lipid Combustion by BAT Activation of B3 adrenergic receptor induce thermogenesis and lipid combustion
  • 15. INCREASE LIPOLYSIS IN WAT AND BAT Lipolysis in WAT fatty acid release hypertriglyceridemia Lipolysis in BAT combustion of fatty acid lower plasma triglyceride levels
  • 17. CONCLUSION WAT,BAT, PVAT play important role in development of atherosclerosis. To reduce risk of atherosclerosis , the most favourable approach to eliminate TRL is, by increasing combustion of fatty acid in BAT, and reduce lipid storage in WAT.
  • 18. Prof. Silvia Biocca (uniroma2.it) (research methodology) First Year Physical Activity and Health Promotion batch 2016/2017 ACKNOWLEDGMENT