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Kuliah Teratologi
(3 SKS)
Oleh : Putra Santoso
Jurusan Biologi FMIPA
Universitas Andalas
Padang, 2017
by putra santoso 2017
by putra santoso 2017
by putra santoso 2017
by putra santoso 2017
by putra santoso 2017
field lilly Veratrum californicum
Sensitive period : 10¨C15 of normal ~150 days) ? cyclopia and holoprosencephaly
< 10 days no effect
> 15 days caused fetal death and limb malformations
Jervine Cyclopamine Cholesterol
by putra santoso 2017
by putra santoso 2017
by putra santoso 2017
by putra santoso 2017
?Perkembangan tungkai
?Diferensiasi neural
?Morfogenesis wajah
?Perkembangan rambut dan bulu
?Pembentukan simetris (midline) tubuh
SHH (sonic hedgehog gene)
by putra santoso 2017
Hubungan SHH dengan kolesterol?
by putra santoso 2017
Credit:
Melissa S Tassinari
Food and Drug Administration
Silver Spring, Maryland
by putra santoso 2017
by putra santoso 2017
The embryonic stem cell test evaluates the
embryotoxicity of a chemical on the basis of its ability to inhibit
embryonic stem cell differentiation and its cytotoxicity to
embryonic relative to adult cells.
by putra santoso 2017
Limb buds removed from mouse embryos on day 12
of gestation were cultured for six days in a roller bottle system with
chemically defined medium in the absence (A) or presence (B) of
retinol acetate (10IU/ml) and stained with toluidine blue.
by putra santoso 2017
In the whole embryo culture system gestation day
10.5 rat embryos (A) are cultured in a roller bottle system in the
presence of rat serum for up to two days (B). In (C) compare the
control embryo on the left to the embryo exposed in vitro to a DNA
damaging agent, 4-hydroperoxycyclophosphamide, on the right.
by putra santoso 2017
Skenario Kuliah Teratologi (Setelah UTS)
8 Dosen
9 Presentasi jurnal 1 & 2
10 Presentasi jurnal 3 & 4
11 Presentasi jurnal 5 & 6
12 Presentasi jurnal 7 & 8
13 Presentasi jurnal 9
14 Ulasan hasil praktikum dan dikskusi
15 UAS
Tugas Individu:
?Pilih salah satu jurnal internasional tentang teratologi
?Kirimkan ke email santosounand@gmail.com untuk ditelaa relevansinya
?Buat ringkasan dalam bentuk poin-poin penting (ketik dan print) :
? Introduction
? Methods
? Results/Mechanisms
Buat presentasi ppt dari jurnal tsb (cukup serahkan file digital)
Kumpulkan minggu depan (Rabu, 18 Oktober 2017)
AKAN DIPILIH SECARA RANDOM DUA PRESENTER PER MINGGU
by putra santoso 2017
Praktikum Mandiri:
Teknik dasar penyediaan hewan uji mencit untuk riset teratologi
Perkawinan induk
Identifikasi status kebuntingan
Perlakuan selama bunting
Identifikasi morfologi luar dan kerangka fetus
by putra santoso 2017
by putra santoso 2017

More Related Content

Teratology Part 1

  • 1. Kuliah Teratologi (3 SKS) Oleh : Putra Santoso Jurusan Biologi FMIPA Universitas Andalas Padang, 2017 by putra santoso 2017
  • 6. field lilly Veratrum californicum Sensitive period : 10¨C15 of normal ~150 days) ? cyclopia and holoprosencephaly < 10 days no effect > 15 days caused fetal death and limb malformations Jervine Cyclopamine Cholesterol by putra santoso 2017
  • 10. ?Perkembangan tungkai ?Diferensiasi neural ?Morfogenesis wajah ?Perkembangan rambut dan bulu ?Pembentukan simetris (midline) tubuh SHH (sonic hedgehog gene) by putra santoso 2017
  • 11. Hubungan SHH dengan kolesterol? by putra santoso 2017
  • 12. Credit: Melissa S Tassinari Food and Drug Administration Silver Spring, Maryland by putra santoso 2017
  • 14. The embryonic stem cell test evaluates the embryotoxicity of a chemical on the basis of its ability to inhibit embryonic stem cell differentiation and its cytotoxicity to embryonic relative to adult cells. by putra santoso 2017
  • 15. Limb buds removed from mouse embryos on day 12 of gestation were cultured for six days in a roller bottle system with chemically defined medium in the absence (A) or presence (B) of retinol acetate (10IU/ml) and stained with toluidine blue. by putra santoso 2017
  • 16. In the whole embryo culture system gestation day 10.5 rat embryos (A) are cultured in a roller bottle system in the presence of rat serum for up to two days (B). In (C) compare the control embryo on the left to the embryo exposed in vitro to a DNA damaging agent, 4-hydroperoxycyclophosphamide, on the right. by putra santoso 2017
  • 17. Skenario Kuliah Teratologi (Setelah UTS) 8 Dosen 9 Presentasi jurnal 1 & 2 10 Presentasi jurnal 3 & 4 11 Presentasi jurnal 5 & 6 12 Presentasi jurnal 7 & 8 13 Presentasi jurnal 9 14 Ulasan hasil praktikum dan dikskusi 15 UAS Tugas Individu: ?Pilih salah satu jurnal internasional tentang teratologi ?Kirimkan ke email santosounand@gmail.com untuk ditelaa relevansinya ?Buat ringkasan dalam bentuk poin-poin penting (ketik dan print) : ? Introduction ? Methods ? Results/Mechanisms Buat presentasi ppt dari jurnal tsb (cukup serahkan file digital) Kumpulkan minggu depan (Rabu, 18 Oktober 2017) AKAN DIPILIH SECARA RANDOM DUA PRESENTER PER MINGGU by putra santoso 2017
  • 18. Praktikum Mandiri: Teknik dasar penyediaan hewan uji mencit untuk riset teratologi Perkawinan induk Identifikasi status kebuntingan Perlakuan selama bunting Identifikasi morfologi luar dan kerangka fetus by putra santoso 2017