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Lymph nodes showed clearance via drainage and increased severity with dose response, though this may be non-adverse and a recovery study could help determine if it is adverse. Adrenal glands showed cortical necrosis in 2 out of 10 rats at the medium exposure, which is considered a severe response, so the no observed adverse effect level is the low exposure.
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- 1. Lymph Node Clearance via lymph node drainage is a part of normal lymph node physiology Not adverse unless severe and associated with necrosis Although there is a dose response and increased severity, this change may be non-adverse. A recovery study would help resolve this issue.
- 2. Adrenal Adrenal cortical necrosis is adverse The 2/10 incidence at the medium exposure is a severe response The NOAEL is the low exposure