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The Endocrine,
Nervous and
Reproductive System
Homeostasis and Feedback Mechanisms
 Homeostasis
 the balance state of internal conditions despite changes
in external environment
 different body systems complement one another to
create internal balance- homeostatic regulation
Homeostasis and Feedback Mechanisms
 Endocrine Glands  secrete hormones that help
regulate the activities of cells
 Stimulus- any external or internal change in the
environment
 External Stimulus- arises from outside the body
 Internal Stimulus- originates within the body
 Feedback mechanism/ feedback regulation- self-
adjusting mechanism
2 Types of Feedback Mechanism
1. Negative feedback loop
- response reduces the stimulus until conditions
return to a homeostatic
state.
The Endocrine, Nervous and Reproductive System.pptx
2 Types of Feedback Mechanism
2. Positive feedback loop
- occurs when a response amplifies a
stimulus, which in turn elicits further
response.
The Endocrine, Nervous and Reproductive System.pptx
Homeostasis and Feedback Mechanisms
 Neuroendocrine System- endocrine + nervous
system
 Hypothalamus- contains neurosecretory cells, sends
hormones.
Target cells
 Blood facilitates the circulation of hormones.
 Hormones are recognized by their target cells via
membrane receptors
 Molecular shape of the hormone should physically fit
the target cells receptor so that the hormone
receptor complex can initiate the response.
The Endocrine System
The Endocrine System
 chemical messengers (hormones)
 2 types of glands
 Endocrine glands
- Release their hormones directly into the
bloodstream
 Exocrine glands
- Release their secretion through ducts
The Endocrine, Nervous and Reproductive System.pptx
Pituitary Gland and Hypothalamus
 Produce hormones and controls various glands
 close to the hypothalamus and is connected to the
blood vessels and nerves
 Master Gland
 Composed of the anterior and posterior lobe
 Posterior lobe
 extension of the hypothalamus
 antidiuretic hormone (ADH) & Oxytocin
The Endocrine, Nervous and Reproductive System.pptx
Pituitary Gland and Hypothalamus
 Antidiuretic hormone (ADH)
 decreases the amount of urine exerted by the
kidneys
 Oxytocin
 promote milk letdown
Pituitary Gland and Hypothalamus
 Anterior lobe
 Secretes rolactin, gonadotropic hormones, thyroid-
stimulating hormone (TSH) and growth hormones.
Thyroid Gland
 located at the base of the neck
 thyroxine is converted into triiodothyronine,
the active form of thyroid hormone
 Calcitonin- lowers calcium levels
 Hypothyroidism- underactive thyroid gland,
decreases metabolic rate
- radioactive iodine treatment
The Endocrine, Nervous and Reproductive System.pptx
Thyroid Gland
 Cretinism- physical and mental retardation
 Goiter- abnormal enlargement of the thyroid
gland
 Levothyroxine- a thyroid hormone
Parathyroid Gland
 at the back of the thyroid gland
 Parathormones
regulate calcium in the blood and oppose the
action of calcitonin
Enhance calcium absorption
Calcium ( muscle contraction, blood clotting and
others)
Adrenal Gland
 above the kidney
 inner part (adrenal medulla)
 outer part (adrenal cortex)
Adrenal Medulla
 epinephrine ( adrenaline) and norepinephrine
(norepinephrine)
 helps the body to respond to emergencies.
 Adrenaline  emergency hormones
Adrenal Cortex
 glucocorticoids, mineralocorticoids and sex
hormones
First two, prolonged stress and mobilizing energy
reserves.
 Cortisol- helps body respond to stress.
 Aldosterone- regulates salt and water in the
body.
Pancreas
 located between the spleen and small intestine.
 produces digestive enzymes and hormones
 Islets of Langerhans- produce pancreatic amylase
 secrete insulin, glucagon and somatostatin
 Insulin- lowers blood sugar level
 Glucagon rises blood sugar level
 Somatostatin- inhibits secretion of other hormones
The Endocrine, Nervous and Reproductive System.pptx

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The Endocrine, Nervous and Reproductive System.pptx

  • 2. Homeostasis and Feedback Mechanisms Homeostasis the balance state of internal conditions despite changes in external environment different body systems complement one another to create internal balance- homeostatic regulation
  • 3. Homeostasis and Feedback Mechanisms Endocrine Glands secrete hormones that help regulate the activities of cells Stimulus- any external or internal change in the environment External Stimulus- arises from outside the body Internal Stimulus- originates within the body Feedback mechanism/ feedback regulation- self- adjusting mechanism
  • 4. 2 Types of Feedback Mechanism 1. Negative feedback loop - response reduces the stimulus until conditions return to a homeostatic state.
  • 6. 2 Types of Feedback Mechanism 2. Positive feedback loop - occurs when a response amplifies a stimulus, which in turn elicits further response.
  • 8. Homeostasis and Feedback Mechanisms Neuroendocrine System- endocrine + nervous system Hypothalamus- contains neurosecretory cells, sends hormones.
  • 9. Target cells Blood facilitates the circulation of hormones. Hormones are recognized by their target cells via membrane receptors Molecular shape of the hormone should physically fit the target cells receptor so that the hormone receptor complex can initiate the response.
  • 11. The Endocrine System chemical messengers (hormones) 2 types of glands Endocrine glands - Release their hormones directly into the bloodstream Exocrine glands - Release their secretion through ducts
  • 13. Pituitary Gland and Hypothalamus Produce hormones and controls various glands close to the hypothalamus and is connected to the blood vessels and nerves Master Gland Composed of the anterior and posterior lobe Posterior lobe extension of the hypothalamus antidiuretic hormone (ADH) & Oxytocin
  • 15. Pituitary Gland and Hypothalamus Antidiuretic hormone (ADH) decreases the amount of urine exerted by the kidneys Oxytocin promote milk letdown
  • 16. Pituitary Gland and Hypothalamus Anterior lobe Secretes rolactin, gonadotropic hormones, thyroid- stimulating hormone (TSH) and growth hormones.
  • 17. Thyroid Gland located at the base of the neck thyroxine is converted into triiodothyronine, the active form of thyroid hormone Calcitonin- lowers calcium levels Hypothyroidism- underactive thyroid gland, decreases metabolic rate - radioactive iodine treatment
  • 19. Thyroid Gland Cretinism- physical and mental retardation Goiter- abnormal enlargement of the thyroid gland Levothyroxine- a thyroid hormone
  • 20. Parathyroid Gland at the back of the thyroid gland Parathormones regulate calcium in the blood and oppose the action of calcitonin Enhance calcium absorption Calcium ( muscle contraction, blood clotting and others)
  • 21. Adrenal Gland above the kidney inner part (adrenal medulla) outer part (adrenal cortex)
  • 22. Adrenal Medulla epinephrine ( adrenaline) and norepinephrine (norepinephrine) helps the body to respond to emergencies. Adrenaline emergency hormones
  • 23. Adrenal Cortex glucocorticoids, mineralocorticoids and sex hormones First two, prolonged stress and mobilizing energy reserves. Cortisol- helps body respond to stress. Aldosterone- regulates salt and water in the body.
  • 24. Pancreas located between the spleen and small intestine. produces digestive enzymes and hormones Islets of Langerhans- produce pancreatic amylase secrete insulin, glucagon and somatostatin Insulin- lowers blood sugar level Glucagon rises blood sugar level Somatostatin- inhibits secretion of other hormones