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The genetics of pain by Edmund Aja Bisong, Vinnitsa 2015

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Ruben Gombalandi
Ruben Gombalandi

This document discusses how genetics can influence pain in several ways. Prostaglandins, which stimulate pain sensations, are synthesized from fatty acids that a person's genes determine the availability of. The COX protein, which is involved in prostaglandin synthesis, is also gene-regulated in terms of amount and amino acid composition. Genetics also influence a person's likelihood of developing allergies, which can be a cause of severe pain. Additionally, genes determine the amount of melanin a person's skin produces, affecting pain responses from sun exposure and healing time from injuries. Rare genetic mutations can even cause congenital insensitivity to pain. Overall, the document examines the genetic underpinnings of many factors that influence a

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The Genetics Of Pain A chat with Pain Deepening and revisualizing pain, and deeper revelations of its mechanisms The pain hypothesis
Prostaglandins Synthesised from unsaturated fatty acids. Availability of fatty acids in cell membrane might be genome- defined. Genetic favourability to having more unsaturated fatty acids. The role of lifestyle in the synthesis and availability of unsaturated fatty acids.
COX Its a protein. Proteins are synthesised from genes. The amount of cycloxygenase is gene regulated, and the amino acids involved are also gene regulated. This will affect the intensity of pain, since cox is responsible for the synthesis of those nociceptive stimulants, like prostaglandins.
Allergies Theres a 50% chance of inheritance of allergies from parents to offspring. Allergies cause severe pain. So, here is our genome again on the fore-front of pain causatives.
Pain and Race Melanocytes filter uv light, like sun rays; thus, preventing skin cancer on a broad sense, and sun-burns on a narrow sense, that could all lead to pain. The healing process would be longer in a black than a white; since these skin cells need to synthesise melanin, as visualised in hyper pigmentation of skin, and scarring mechanisms. We all have the same number of melanocytes, but not melanin.
Pseudopain? Masochists; an interaction between the lateral spinothalamic tract and the limbic system. Overriding some impulses Mechanical stimuli can inhibit pain fibres.
Pain and Your Cortex Role of frontal cortex in pain perception. Pain adaptation? We have been told that the fibres themselves have zero adaptation, but, do their interactions with the limbic system suffer the same fate? Throwing light on ACUPUNCTURE.
Analgia Congenitalis Mutation in the gene responsible for the synthesis of Na+ pumps, thus, inability to transmit pain sensation (nociception). Mutation of this gene in olfactory neurones leads to anosmia. Analgia congenitalis can b inherited as an autosomal recessive congenital disorder. If theres a mutation in the gene responsible for the synthesis and availability of the enzyme cox, therell be absence of healingand maybe, absence of ageing. The LEGEND OF VAMPIRES. The series; HEROES, where a high-school girl Claire had a similar condition. Maybe the film-makers where right.
Pro-pain Organ failure. The viscera could feel some sort of pain that we are not even aware of. Think of asymptomatic stage(s) of a disease; when your body fights pain sub-cortically.
THE BRAIN IS THE WHOLE UNIVERSE COMPRESSED INTO A FLUID-FILLED CAVITY

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The genetics of pain by Edmund Aja Bisong, Vinnitsa 2015

  • 1. The Genetics Of Pain A chat with Pain Deepening and revisualizing pain, and deeper revelations of its mechanisms The pain hypothesis
  • 2. Prostaglandins Synthesised from unsaturated fatty acids. Availability of fatty acids in cell membrane might be genome- defined. Genetic favourability to having more unsaturated fatty acids. The role of lifestyle in the synthesis and availability of unsaturated fatty acids.
  • 3. COX Its a protein. Proteins are synthesised from genes. The amount of cycloxygenase is gene regulated, and the amino acids involved are also gene regulated. This will affect the intensity of pain, since cox is responsible for the synthesis of those nociceptive stimulants, like prostaglandins.
  • 4. Allergies Theres a 50% chance of inheritance of allergies from parents to offspring. Allergies cause severe pain. So, here is our genome again on the fore-front of pain causatives.
  • 5. Pain and Race Melanocytes filter uv light, like sun rays; thus, preventing skin cancer on a broad sense, and sun-burns on a narrow sense, that could all lead to pain. The healing process would be longer in a black than a white; since these skin cells need to synthesise melanin, as visualised in hyper pigmentation of skin, and scarring mechanisms. We all have the same number of melanocytes, but not melanin.
  • 6. Pseudopain? Masochists; an interaction between the lateral spinothalamic tract and the limbic system. Overriding some impulses Mechanical stimuli can inhibit pain fibres.
  • 7. Pain and Your Cortex Role of frontal cortex in pain perception. Pain adaptation? We have been told that the fibres themselves have zero adaptation, but, do their interactions with the limbic system suffer the same fate? Throwing light on ACUPUNCTURE.
  • 8. Analgia Congenitalis Mutation in the gene responsible for the synthesis of Na+ pumps, thus, inability to transmit pain sensation (nociception). Mutation of this gene in olfactory neurones leads to anosmia. Analgia congenitalis can b inherited as an autosomal recessive congenital disorder. If theres a mutation in the gene responsible for the synthesis and availability of the enzyme cox, therell be absence of healingand maybe, absence of ageing. The LEGEND OF VAMPIRES. The series; HEROES, where a high-school girl Claire had a similar condition. Maybe the film-makers where right.
  • 9. Pro-pain Organ failure. The viscera could feel some sort of pain that we are not even aware of. Think of asymptomatic stage(s) of a disease; when your body fights pain sub-cortically.
  • 10. THE BRAIN IS THE WHOLE UNIVERSE COMPRESSED INTO A FLUID-FILLED CAVITY