Skin is an important immune organ that serves as a protective interface, shielding organs and tissue from the environment.
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The Role of Skin in the Human Immune System
1. in the Human Immune
System
Dr Carolyn Dean
is a medical doctor and naturopath. She has
authored and co-authored over 35 books
The Role of Skin
2. 2
The Role of Skin
in the Human
Immune System
Skin is an important immune organ that
serves as a protective interface, shielding
organs and tissue from the environment.
Skin provides a physical barrier from the
pathogenic organisms, toxins, and physical
stresses encountered in everyday life.
Dr. Carolyn Dean
Skin protects the body from
infection, toxins, and cancer.
Sometimes referred to as
skin-associated lymphoid
tissue, the skin immune
system includes the lymph
nodes, as well as peripheral
lymphoid organs such as the
spleen.
Key immune cells in the ep-
idermis are skin cells known
as keratinocytes, and epi-
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dermal dendritic cells called Langer-
hans cells. In addition to lymph and
blood vessels, the dermis contains
numerous immune cells, including
mast cells, dermal dendric cells, B
cells, T cells and natural killer cells.
Immune cells are continuously traf-
ficked between the blood circulation,
the skin and draining lymph nodes.
The skin microbiome is an important
contributor to homeostasis of the skin
immune system.
In terms of protecting the body from
infection, the skin is the first line of
defense. Langerhans cells in particu-
lar are thought to play a pivotal role in
detecting and transporting antigens to
lymph nodes and other immune cells
to initiate an immune response.
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For more information about skin health,
Dr. Carolyne Dean